4.5 Review

Investigational drugs for the treatment of kidney transplant rejection

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Surgery

The negative impact of T cell-mediated rejection on renal allograft survival in the modern era

Christie Rampersad et al.

Summary: The study shows that in kidney transplant recipients receiving tacrolimus/mycophenolate-based maintenance therapy, TCMR is common, correlates with HLA-DR/DQ molecular mismatch scores, and is associated with the risk of graft loss.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

Article Urology & Nephrology

Evaluation of Clazakizumab (Anti-Interleukin-6) in Patients With Treatment-Resistant Chronic Active Antibody-Mediated Rejection of Kidney Allografts

Stanley C. Jordan et al.

Summary: This study investigated the use of clazakizumab, an IL-6 inhibitor, in patients with cAMR. The results showed that clazakizumab treatment stabilized kidney function, reduced antibody production, and decreased graft inflammation. No significant safety issues were observed.

KIDNEY INTERNATIONAL REPORTS (2022)

Article Pharmacology & Pharmacy

Clinical and Molecular Profiling to Develop a Potential Prediction Model for the Response to Alemtuzumab Therapy for Acute Kidney Transplant Rejection

Daphne M. Hullegie-Peelen et al.

Summary: This study developed a multidimensional prediction model and improved the prediction of alemtuzumab treatment response through gene expression analysis. It may be helpful for the development of stratified alemtuzumab treatment for acute kidney transplant rejection, but validation is required.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2022)

Review Immunology

Shifting Clinical Trial Endpoints in Kidney Transplantation: The Rise of Composite Endpoints and Machine Learning to Refine Prognostication

Imran J. Anwar et al.

Summary: This article reviews the evolution of outcomes measurements in kidney transplantation over the past two decades and summarizes recent advances in clinical, histopathological, and immune outcomes measurements. The article also discusses the use of composite endpoints and Bayesian concepts, as well as the integration of the integrative box risk prediction score with machine learning for prognostication improvement.

TRANSPLANTATION (2022)

Article Medicine, Research & Experimental

Safety, tolerability, and efficacy of monoclonal CD38 antibody felzartamab in late antibody-mediated renal allograft rejection: study protocol for a phase 2 trial

Katharina A. Mayer et al.

Summary: This study is a randomized, placebo-controlled, double-blind, multi-center clinical trial investigating the use of CD38-directed treatment with felzartamab in late-stage antibody-mediated rejection (ABMR). The study aims to evaluate the safety, tolerability, pharmacokinetics, immunogenicity, and efficacy of felzartamab in ABMR, and examine its impact on the progression of the disease.

TRIALS (2022)

Article Surgery

Allograft Function as Endpoint for Clinical Trials in Kidney Transplantation

Luuk Hilbrands et al.

Summary: Clinical study endpoints that assess efficacy of interventions in patients with chronic renal insufficiency can be applied to kidney transplantation trials due to pathophysiological similarities. Glomerular filtration rate (GFR) and estimated (e)GFR trajectories have been used as primary endpoints in clinical trials for chronic kidney disease (CKD), and similar approaches can be considered for kidney transplantation trials.

TRANSPLANT INTERNATIONAL (2022)

Article Immunology

CD38 Antibody Daratumumab for the Treatment of Chronic Active Antibody-mediated Kidney Allograft Rejection

Konstantin Doberer et al.

Summary: The study highlights the potential of targeting CD38 for plasma cell and NK cell depletion in treating AMR. The use of daratumumab in a kidney allograft recipient with chronic active AMR led to significant improvements in immune cell counts, donor-specific antibody levels, and rejection-related gene expression patterns. This innovative treatment concept shows promise for future trials in organ transplantation research.

TRANSPLANTATION (2021)

Article Immunology

Imlifidase Desensitization in Crossmatch-positive, Highly Sensitized Kidney Transplant Recipients: Results of an International Phase 2 Trial (Highdes)

Stanley C. Jordan et al.

Summary: This study investigated the efficacy and safety of imlifidase in converting a positive crossmatch test to negative in highly sensitized patients, allowing them to undergo kidney transplantation. Results showed that majority of transplanted patients achieved negative crossmatch within 24 hours after imlifidase treatment, with good kidney function and graft survival at 6 months.

TRANSPLANTATION (2021)

Article Surgery

Do anti-IL-6R blockers have a beneficial effect in the treatment of antibody-mediated rejection resistant to standard therapy after kidney transplantation?

Maeva Massat et al.

Summary: This study found that monthly infusions of tocilizumab did not alter the progression of antibodies in patients with antibody-mediated rejection resistant to standard of care therapy. There were no significant differences in graft survival and decline in renal function between patients who received tocilizumab and those who did not. Despite a decrease in inflammation and tubulitis scores, the course of antibody-mediated lesions and chronic glomerulopathy were similar in both groups.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

Review Biotechnology & Applied Microbiology

A review of imlifidase in solid organ transplantation

Bonnie E. Lonze

Summary: With the emergence of the new drug imlifidase, patients with donor-specific antibodies may have access to more effective treatment, bringing new hope for organ transplant patients in urgent need.

EXPERT OPINION ON BIOLOGICAL THERAPY (2021)

Article Urology & Nephrology

A Randomized Clinical Trial of Anti-IL-6 Antibody Clazakizumab in Late Antibody-Mediated Kidney Transplant Rejection

Konstantin Doberer et al.

Summary: This study was a phase 2 randomized trial evaluating the safety and efficacy of the anti-IL-6 antibody clazakizumab in late antibody-mediated rejection (ABMR) post-transplantation. Results showed that patients receiving clazakizumab had decreased donor-specific antibodies and modulated rejection-related gene-expression patterns.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

Article Immunology

BLyS neutralization results in selective anti-HLA alloantibody depletion without successful desensitization

Divyansh Agarwal et al.

Summary: In highly sensitized kidney transplant candidates, BLyS blockade did not significantly reduce total anti-HLA allo-Ab levels but resulted in selective depletion of antibodies recognizing specific HLA allele specificities.

TRANSPLANT IMMUNOLOGY (2021)

Review Pharmacology & Pharmacy

Therapies for Chronic Allograft Rejection

Min Young Kim et al.

Summary: Significant progress has been made in the pathophysiology, diagnosis, and treatment of antibody-mediated rejection (ABMR) in recent decades, but effective treatment for chronic ABMR remains a challenge. Chronic ABMR has a distinct phenotype from active ABMR and is mainly caused by de novo donor specific antibodies (DSA), leading to progressive graft injury.

FRONTIERS IN PHARMACOLOGY (2021)

Review Immunology

HLA Desensitization in Solid Organ Transplantation: Anti-CD38 to Across the Immunological Barriers

Nizar Joher et al.

Summary: The presence of anti-HLA antibodies is a major barrier to solid organ transplantation. Desensitization protocols have shown improvements in transplantation rates but limitations still exist, prompting interest in new desensitization approaches focused on targeting alloimmune pathways beyond antibodies. Targeting CD38 to desensitize in the field of transplantation is an emerging concept worth further exploration.

FRONTIERS IN IMMUNOLOGY (2021)

Review Medicine, General & Internal

Long-Term Survival after Kidney Transplantation

Sundaram Hariharan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Oncology

Isatuximab: A Review of Its Use in Multiple Myeloma

James E. Frampton

Summary: Isatuximab, an anti-CD38 monoclonal antibody, has shown significant efficacy in combination with pomalidomide, dexamethasone, and carfilzomib in patients with multiple myeloma, making it a potential important treatment option for patients with RRMM and relapsed MM.

TARGETED ONCOLOGY (2021)

Article Immunology

Alemtuzumab as Second-Line Treatment for Late Antibody-Mediated Rejection of Transplanted Kidneys

Michiel G. H. Betjes et al.

Summary: The study suggests that alemtuzumab may be an effective treatment option for late ABMR, stabilizing or improving eGFR in patients with good tolerance.

TRANSPLANTATION PROCEEDINGS (2021)

Review Immunology

Emerging New Approaches in Desensitization: Targeted Therapies for HLA Sensitization

Ashley Y. Choi et al.

Summary: Sensitized patients with preformed or de novo DSA are at increased risk of AMR and allograft loss. Conventional desensitization methods targeting antibody or B cell removal often fail to efficiently clear all DSA, so interventions targeting multiple components of humoral immunity are needed to improve patient outcomes.

FRONTIERS IN IMMUNOLOGY (2021)

Review Pharmacology & Pharmacy

Costimulation Blockade in Kidney Transplant Recipients

Marieke van der Zwan et al.

Review Surgery

B cells in transplant tolerance and rejection: friends or foes?

Robin Schmitz et al.

TRANSPLANT INTERNATIONAL (2020)

Article Health Care Sciences & Services

Indications for Rituximab Use in an Integrated Health Care Delivery System

Thomas Delate et al.

Journal of Managed Care & Specialty Pharmacy (2020)

Article Multidisciplinary Sciences

Desensitization and treatment with APRIL/BLyS blockade in rodent kidney transplant model

Natalie M. Bath et al.

PLOS ONE (2019)

Article Immunology

APRIL/BLyS Blockade Reduces Donor-specific Antibodies in Allosensitized Mice

Nancy A. Wilson et al.

TRANSPLANTATION (2019)

Article Urology & Nephrology

Daratumumab in Sensitized Kidney Transplantation: Potentials and Limitations of Experimental and Clinical Use

Jean Kwun et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2019)

Article Urology & Nephrology

Daratumumab for Treatment of Antibody-Mediated Rejection after ABO-Incompatible Kidney Transplantation

Davide Spica et al.

CASE REPORTS IN NEPHROLOGY AND DIALYSIS (2019)

Article Urology & Nephrology

A Randomized Trial of Bortezomib in Late Antibody-Mediated Kidney Transplant Rejection

Farsad Eskandary et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

Review Medicine, General & Internal

Antibody-Mediated Rejection of Solid-Organ Allografts

Alexandre Loupy et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Pharmacology & Pharmacy

Review of the Clinical Pharmacokinetics and Pharmacodynamics of Alemtuzumab and Its Use in Kidney Transplantation

Marieke van der Zwan et al.

CLINICAL PHARMACOKINETICS (2018)

Review Urology & Nephrology

Complement Recognition Pathways in Renal Transplantation

Christopher L. Nauser et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Article Medicine, General & Internal

IgG Endopeptidase in Highly Sensitized Patients Undergoing Transplantation

S. C. Jordan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Medicine, General & Internal

Overexpression of the Cytokine BAFF and Autoimmunity Risk

M. Steri et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Oncology

Proteasome inhibitors: structure and function

Ana T. Nunes et al.

SEMINARS IN ONCOLOGY (2017)

Review Biotechnology & Applied Microbiology

Tocilizumab (Actemra)

Martin Sheppard et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2017)

Review Health Care Sciences & Services

Alemtuzumab: a review of efficacy and risks in the treatment of relapsing remitting multiple sclerosis

Cristina Guarnera et al.

THERAPEUTICS AND CLINICAL RISK MANAGEMENT (2017)

Review Surgery

Complement inhibition as potential new therapy for antibody-mediated rejection

Farsad Eskandary et al.

TRANSPLANT INTERNATIONAL (2016)

Article Surgery

Inflammation Causes Resistance to Anti-CD20-Mediated B Cell Depletion

L. H. Laws et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2016)

Review Immunology

The Complement System and Antibody-Mediated Transplant Rejection

Erik Stites et al.

JOURNAL OF IMMUNOLOGY (2015)

Review Biochemistry & Molecular Biology

The perfect storm: HLA antibodies, complement, FcγRs, and endothelium in transplant rejection

Kimberly A. Thomas et al.

TRENDS IN MOLECULAR MEDICINE (2015)

Article Immunology

A systematic review of the use of rituximab as induction therapy in renal transplantation

Philip S. Macklin et al.

TRANSPLANTATION REVIEWS (2015)

Article Medicine, General & Internal

Antibody-mediated vascular rejection of kidney allografts: a population-based study

Carmen Lefaucheur et al.

LANCET (2013)

Article Pharmacology & Pharmacy

Therapeutic Cleavage of Anti-Aquaporin-4 Autoantibody in Neuromyelitis Optica by an IgG-Selective Proteinase

Lukmanee Tradtrantip et al.

MOLECULAR PHARMACOLOGY (2013)

Article Immunology

Role of complement and NK cells in antibody mediated rejection

Takurin Akiyoshi et al.

HUMAN IMMUNOLOGY (2012)

Article Immunology

Eculizumab Treatment of Acute Antibody-Mediated Rejection in Renal Transplantation: Case Reports

F. Gonzalez-Roncero et al.

TRANSPLANTATION PROCEEDINGS (2012)

Article Immunology

Mechanisms involved in antibody- and complement-mediated allograft rejection

Barbara A. Wasowska

IMMUNOLOGIC RESEARCH (2010)

Article Urology & Nephrology

KDIGO clinical practice guideline for the care of kidney transplant recipients: a summary

Bertram L. Kasiske et al.

KIDNEY INTERNATIONAL (2010)

Review Medicine, General & Internal

Mechanisms of Disease: Rejection of the Kidney Allograft.

Brian J. Nankivell et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Editorial Material Pharmacology & Pharmacy

Eculizumab

Eline A. Dubois et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2009)

Review Immunology

Cracking the BAFF code

Fabienne Mackay et al.

NATURE REVIEWS IMMUNOLOGY (2009)

Article Transplantation

C5 Blockade with Conventional Immunosuppression Induces Long-Term Graft Survival in Presensitized Recipients

R. P. Rother et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2008)

Article Multidisciplinary Sciences

IdeS: A Bacterial Proteolytic Enzyme with Therapeutic Potential

Bjorn P. Johansson et al.

PLOS ONE (2008)

Article Rheumatology

Blocking of experimental arthritis by cleavage of IgG antibodies in vivo

Kutty Selva Nandakumar et al.

ARTHRITIS AND RHEUMATISM (2007)

Article Multidisciplinary Sciences

Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG

K Wenig et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Immunology

CD40/CD154 interactions at the interface of tolerance and immunity

SA Quezada et al.

ANNUAL REVIEW OF IMMUNOLOGY (2004)

Article Immunology

Anti-CD40 therapy extends renal allograft survival in rhesus macaques

TC Pearson et al.

TRANSPLANTATION (2002)

Article Biochemistry & Molecular Biology

IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G

U von Pawel-Rammingen et al.

EMBO JOURNAL (2002)

Article Biochemistry & Molecular Biology

Structural basis of BLyS receptor recognition

DA Oren et al.

NATURE STRUCTURAL BIOLOGY (2002)

Review Cell Biology

CD40-CD40 ligand

C van Kooten et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2000)