期刊
EXPERT OPINION ON DRUG SAFETY
卷 22, 期 5, 页码 417-424出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14740338.2023.2134344
关键词
Biological DMARDs; inflammatory rheumatic diseases; adverse drug reactions; burden; perspectives
This study explored the perceptions of inflammatory rheumatic disease patients and healthcare professionals on the burden of adverse drug reactions (ADRs). The findings revealed that both patients and healthcare professionals consider ADRs to have both physical and psychological impacts, with healthcare professionals placing more emphasis on the psychological consequences.
Background Previous studies showed a discrepancy between health-care professionals' (HCPs') and patients' perspective on adverse drug reaction (ADR) burden. However, it is unclear which factors make an ADR burdensome. We aimed to give insight into why ADRs are perceived as burdensome by inflammatory rheumatic disease (IRD) patients, and whether this differs from the HCPs' perspective. Research design and methods A qualitative study was conducted using Dutch Biologic Monitor data. Participants received bimonthly questionnaires on experienced ADRs attributed to biological DMARDs and were asked to elaborate on ADR burden using a Likert-type scale and an open-ended question for clarification. Data of 440 IRD patients were analyzed following thematic analysis. A similar analysis was done with semi-structured interviews with 13 HCPs. Results We identified seven themes associated with ADR burden: 'effect on medication prescription,' 'impact on appearance,' 'impact on autonomy,' 'impact on daily life,' 'psychological consequences,' 'distressing aspects of ADR,' and 'physical consequences.' Identical themes were identified by HCPs, although they identified most subthemes in 'psychological consequences,' and less subthemes in 'impact on daily life' and 'impact on autonomy.' Conclusion Patients describe perceived ADR burden in both physical and psychological themes. The HCPs' perspective is comparable, but mostly focuses on psychological impact.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据