4.3 Review

Anti-IL 23 biologics for the treatment of plaque psoriasis

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Summary: Risankizumab treatment significantly improves signs and symptoms of PsA compared to placebo, demonstrating significant differences in skin and nail psoriasis endpoints, minimal disease activity, and resolution of enthesitis and dactylitis. Adverse events were reported at similar rates in the risankizumab and placebo groups.

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Consistent safety profile with up to 5 years of continuous treatment with guselkumab: Pooled analyses from the phase 3 VOYAGE 1 and VOYAGE 2 trials of patients with moderate-to-severe psoriasis

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Summary: This study demonstrates that the safety profile of continuous guselkumab treatment for psoriasis remains consistent and favorable over a period of 5 years, with low rates of adverse events and no increasing trend observed.

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M. Gooderham et al.

Summary: This study analyzed the efficacy and improvement in quality of life in patients with moderate-to-severe plaque psoriasis treated with Risankizumab. The results showed that a higher proportion of patients in the Risankizumab group achieved absolute PASI thresholds compared to the ustekinumab group, and achieved them in a shorter time. Among patients treated with long-term Risankizumab, over 90% achieved PASI <= 3, and over 80% achieved DLQI 0/1. Patients with low absolute PASI scores also had low mean absolute DLQI scores throughout the 172 weeks of continuous Risankizumab treatment.

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Summary: Deucravacitinib has shown therapeutic benefit in adults with moderate to severe plaque psoriasis, improving clinical outcomes and quality of life. It has the potential to become a promising new oral therapy for this condition.

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Efficacy and safety of selective TYK2 inhibitor, deucravacitinib, in a phase II trial in psoriatic arthritis

Philip J. Mease et al.

Summary: This study evaluated the efficacy and safety of deucravacitinib, a selective TYK2 inhibitor, in patients with active PsA. The results showed that treatment with deucravacitinib led to significant improvements in ACR-20 response, multiplicity-controlled secondary endpoints, and other exploratory efficacy measures. The treatment was well tolerated.

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IL-23 inhibition for the treatment of psoriatic arthritis

Raagav Mohanakrishnan et al.

Summary: Psoriatic arthritis (PsA) is a complex immune-mediated disease, with IL-23p19 inhibitors showing promising efficacy and safety in its treatment. Although lacking direct comparisons with other PsA targeted therapies, IL-23p19 inhibitors have the potential to become first-line biologics due to their superior safety profile and comparable efficacy in treating PsA.

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D. Thaci et al.

Summary: The research demonstrates that treatment with the anti-interleukin-23p19 monoclonal antibody tildrakizumab provides sustained disease control over 5 years for psoriasis patients, with a reassuring safety profile.

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Efficacy and safety of tildrakizumab in patients with active psoriatic arthritis: results of a randomised, double-blind, placebo-controlled, multiple-dose, 52-week phase IIb study

Philip J. Mease et al.

Summary: Tildrakizumab treatment significantly improved joint and skin manifestations of PsA, with good tolerability through Week 52. However, the effectiveness on dactylitis and enthesitis was not significant.

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Christopher E M Griffiths et al.

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Ayla Hoogendoorn et al.

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Five-year maintenance of clinical response and health-related quality of life improvements in patients with moderate-to-severe psoriasis treated with guselkumab: results from VOYAGE 1 and VOYAGE 2

K. Reich et al.

Summary: Guselkumab maintained high levels of clinical response and improvement in patient-reported outcomes through 252 weeks of treatment in patients with moderate-to-severe psoriasis.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Long-term efficacy and safety of risankizumab for the treatment of moderate-to-severe plaque psoriasis: interim analysis of the LIMMitless open-label extension trial beyond 3 years of follow-up

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Summary: The study evaluated the long-term efficacy and safety of risankizumab for psoriasis treatment, with results showing high and durable efficacy over 172 weeks and low rates of adverse events.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Latest Advances for the Treatment of Chronic Plaque Psoriasis with Biologics and Oral Small Molecules

Francesco Bellinato et al.

Summary: Psoriasis is a common immune-mediated chronic skin disease whose severity can be influenced by multiple factors. In recent years, there has been a growing understanding of its pathophysiology, leading to the development of effective and safe treatments, including biologicals.

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Kotaro Ogawa et al.

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Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics

Alan Menter et al.

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Phase 2 Trial of Selective Tyrosine Kinase 2 Inhibition in Psoriasis

Kim Papp et al.

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Junko Takeshita et al.

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Wolf-Henning Boehncke et al.

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M. Lebwohl et al.

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Charles W. Lynde et al.

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Richard G. Langley et al.

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Long-term efficacy of ustekinumab in patients with moderate-to-severe psoriasis treated for up to 5 years in the PHOENIX 1 study

A. B. Kimball et al.

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Michelle A. Lowes et al.

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Cyclosporine and psoriasis: 2008 National Psoriasis Foundation Consensus Conference

David M. Rosmarin et al.

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Methotrexate and psoriasis: 2009 National Psoriasis Foundation Consensus Conference

Robert E. Kalb et al.

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Adalimumab therapy for moderate to severe psoriasis: A randomized, controlled phase III trial

Alan Menter et al.

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K Gordon et al.

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