4.6 Article

Exosomes from adipose-derived stem cells inhibit inflammation and oxidative stress in LPS-acute kidney injury

期刊

EXPERIMENTAL CELL RESEARCH
卷 420, 期 1, 页码 -

出版社

ELSEVIER INC
DOI: 10.1016/j.yexcr.2022.113332

关键词

Adipose-derived MSCs; AKI; LPS; Oxidative stress; Bone marrow-derived MSCs; Exosome

资金

  1. National Natural Science Foundation of China
  2. Scientific and Technological Project in Henan Province [8210061531]
  3. Joint Project from Henan Health Commission [222102310261]
  4. [LHGJ20210587]

向作者/读者索取更多资源

Exosomes derived from adipose tissue and bone marrow mesenchymal stem cells (MSCs) can reduce oxidative stress and inflammation, improve kidney function and structure, and protect against lipopolysaccharide-induced acute kidney injury (AKI).
Acute renal damage presents a significant danger to kidney health. Previous research has found that acute kidney injury shows high levels of oxidative stress and inflammation caused by sepsis. Although mesenchymal stem cells (MSCs) can repair acute kidney injury. However, involvement of MSCs exosomes generated from adipose tissue and bone marrow in lipopolysaccharide-induced acute kidney damage is not clear. LPS (7.5 mg/kg) intraperitoneal injection was used to produce AKI, and 30 min before the LPS administration, adipose-derived MSCs (ADSCs) exosomes (1 x 10(5) and 5 x 10(5)) and bone marrow-derived MSCs(BMSCs) exosomes (1 x 10(5) and 5 x 10(5)) were delivered individually. The function of the rat kidney was explored. Inflammation, oxidative stress, and autophagy levels were further investigated. Both adipose-derived and bone marrow-derived MSCs can enhance renal function and structural damage, such as BUN, Creatinine, and cystatin C levels, as well as tubular damage scores. These findings indicate that both adipose-derived MSCs exosomes and bone marrow-derived MSCs exosomes decrease oxidative stress and inflammation, as well as make a substantial influence on kidney tissue in autophagy levels. Furthermore, compared to bone marrow-derived MSCs exosomes, adipose-derived MSCs exosomes improved kidney function and structure more significantly. We discovered that adipose-derived MSCs exosomes protect against LPS-induced AKI by inhibiting oxidative stress and inflammation.

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