4.6 Article

The effect of HIF-1α inhibition in breast cancer cells prior to doxorubicin treatment under conditions of normoxia and hypoxia

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Genetics & Heredity

Therapeutic Targeting Hypoxia-Inducible Factor (HIF-1) in Cancer: Cutting Gordian Knot of Cancer Cell Metabolism

Abhilasha Sharma et al.

Summary: Metabolic alterations are a hallmark of cancer, and the tumor microenvironment can promote these changes. HIF-1 is an important transcription factor involved in regulating the Warburg effect, thus making it a potential target for cancer therapy.

FRONTIERS IN GENETICS (2022)

Review Oncology

The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment

Asieh Emami Nejad et al.

Summary: Tumor hypoxia, caused by rapid tumor growth and abnormal blood vessel formation, can activate angiogenesis, increase tumor survival, suppress immunity, and requires management through mechanisms such as altering gene expression. The potential use of cancer stem cells in tumor treatment has been highlighted.

CANCER CELL INTERNATIONAL (2021)

Article Multidisciplinary Sciences

The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis

Fang Zheng et al.

Summary: The study demonstrates a crucial positive feed-forward loop between HIFAL, the HIF1alpha antisense long non-coding RNA, and HIF1alpha, which is essential for metabolic reprogramming and tumourigenesis mediated by HIF1alpha.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Doxorubicin-transferrin conjugate alters mitochondrial homeostasis and energy metabolism in human breast cancer cells

Paulina Wigner et al.

Summary: The DOX-Tf conjugate as a drug delivery system exhibits higher cytotoxicity in human breast adenocarcinoma cells, especially in triple-negative breast cancer cells. Our findings also suggest that the functionality of cellular antioxidant systems and expression levels of estrogen receptors in breast cancer cells may influence the sensitivity to DOX-Tf conjugate.

SCIENTIFIC REPORTS (2021)

Article Multidisciplinary Sciences

HER2+breast cancers evade anti-HER2 therapy via a switch in driver pathway

Alison E. Smith et al.

Summary: Resistance to HER2 inhibition in HER2-amplified breast cancer is common in the metastatic setting, with genetic activation of MAPK identified as a recurrent mechanism of resistance. MEK/ERK inhibitors may effectively combat this resistance by targeting the driver pathway switch to CDK2 activation.

NATURE COMMUNICATIONS (2021)

Review Biochemistry & Molecular Biology

AMPK-mTOR Signaling and Cellular Adaptations in Hypoxia

Yoomi Chun et al.

Summary: Cellular energy is primarily generated through the oxidative degradation of nutrients and mitochondrial respiration, with oxygen participating in the electron transport chain. Oxygen supply plays a crucial role in intracellular bioenergetics. Hypoxia leads to nutrient starvation, integrating hypoxic signaling and nutrient signaling at the cellular level.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

Hypoxia-inducible factor-1α expression and breast cancer recurrence in a Danish population-based case control study

Lindsay J. Collin et al.

Summary: The study found that HIF-1α expression is not directly associated with overall breast cancer recurrence, but may be related to early recurrence in patients with ER-negative breast cancer.

BREAST CANCER RESEARCH (2021)

Review Cell Biology

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky et al.

Summary: The guidelines presented in this article aim to assist researchers in selecting and interpreting methods to examine autophagy, as well as to help reviewers provide constructive critiques of reports focused on these processes. It emphasizes that no single assay is perfect for every situation, and multiple techniques may be needed to properly monitor autophagy in different experimental settings. The article also highlights the importance of targeting multiple autophagy-related genes in genetic approaches to block autophagy effectively.

AUTOPHAGY (2021)

Article Pharmacology & Pharmacy

Doxorubicin Induces Endotheliotoxicity and Mitochondrial Dysfunction via ROS/eNOS/NO Pathway

Huan He et al.

FRONTIERS IN PHARMACOLOGY (2020)

Review Cell Biology

Mitophagy, Mitochondrial Homeostasis, and Cell Fate

Kaili Ma et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Oncology

Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences

Mara Cirone et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Article Chemistry, Multidisciplinary

Molecular and Cellular Response of Co-cultured Cells toward Cobalt Chloride (CoCl2)-Induced Hypoxia

Vinay Kumar Tripathi et al.

ACS OMEGA (2019)

Review Biochemistry & Molecular Biology

Hypoxia optimises tumour growth by controlling nutrient import and acidic metabolite export

Scott K. Parks et al.

MOLECULAR ASPECTS OF MEDICINE (2016)

Article Biochemistry & Molecular Biology

Changes in mitochondrial redox state, membrane potential and calcium precede mitochondrial dysfunction in doxorubicin-induced cell death

Andrey V. Kuznetsov et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)

Article Biochemistry & Molecular Biology

Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels

Paul T. Mungai et al.

MOLECULAR AND CELLULAR BIOLOGY (2011)

Review Veterinary Sciences

Hypoxia-inducible factors - regulation, role and comparative aspects in tumourigenesis

A. E. Hansen et al.

VETERINARY AND COMPARATIVE ONCOLOGY (2011)

Article Biochemistry & Molecular Biology

Hypoxia and mitochondrial oxidative metabolism

Giancarlo Solaini et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2010)

Article Cell Biology

Hypoxic Enlarged Mitochondria Protect Cancer Cells From Apoptotic Stimuli

Johanna Chiche et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2010)

Article Pharmacology & Pharmacy

HIF-1α-dependent autophagy protects HeLa cells from fenretinide (4-HPR)-induced apoptosis in hypoxia

Xiao-Wen Liu et al.

PHARMACOLOGICAL RESEARCH (2010)

Article Chemistry, Multidisciplinary

Cobalt chloride, a chemical inducer of hypoxia-inducible factor-1α in U251 human glioblastoma cell line

Majed S. Al Okail

JOURNAL OF SAUDI CHEMICAL SOCIETY (2010)

Review Pharmacology & Pharmacy

Hypoxia targeting gene expression for breast cancer gene therapy

Minhyung Lee

ADVANCED DRUG DELIVERY REVIEWS (2009)

Article Biochemistry & Molecular Biology

In vitro effects of 2-methoxyestradiol on MCF-12A and MCF-7 cell growth, morphology and mitotic spindle formation

Catherina Van Zijl et al.

CELL BIOCHEMISTRY AND FUNCTION (2008)

Article Oncology

Her2-positive breast cancer: Herceptin and beyond

Windy Dean-Colomb et al.

EUROPEAN JOURNAL OF CANCER (2008)

Article Endocrinology & Metabolism

Melatonin modulates the expression of VEGF and HIF-1α induced by CoCl2 in cultured cancer cells

Min Dai et al.

JOURNAL OF PINEAL RESEARCH (2008)

Article Biochemistry & Molecular Biology

DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells

M. Katayama et al.

CELL DEATH AND DIFFERENTIATION (2007)

Article Biochemistry & Molecular Biology

Cell-specific regulation of hypoxia-inducible factor (HIF)-1α and HIF-2α stabilization and transactivation in a graded oxygen environment

Cameron P. Bracken et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1α

DA Chan et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Disruption of fusion results in mitochondrial heterogeneity and dysfunction

HC Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Review Biochemistry & Molecular Biology

Autophagy as a cell death and tumor suppressor mechanism

D Gozuacik et al.

ONCOGENE (2004)

Article Biochemistry & Molecular Biology

Concentration-dependent mitogenic and antiproliferative actions of 2-methoxyestradiol in estrogen receptor-positive human breast cancer cells

ZJ Liu et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2004)

Article Multidisciplinary Sciences

Structural basis of mitochondrial tethering by mitofusin complexes

T Koshiba et al.

SCIENCE (2004)

Article Multidisciplinary Sciences

A conserved family of prolyl-4-hydroxylases that modify HIF

RK Bruick et al.

SCIENCE (2001)

Article Biochemistry & Molecular Biology

Hypoxia in vivo decreases peroxisome proliferator-activated receptor α-regulated gene expression in rat heart

P Razeghi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)