期刊
EXPERIMENTAL CELL RESEARCH
卷 418, 期 1, 页码 -出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2022.113245
关键词
PCDH17; Methylation; DNMT3B; Malignant biological behavior; HCC; EMT
资金
- National Natural Science Foundation of China [82100604]
- medical scientific research project of Chengdu Health Committee [2019069]
- Sichuan applied basic research project of Sichaun Science and Technology Department [2018JY0276]
- Chengdu Science and Technology Innovation Research and Development project [2018-YF05-01228-SN]
- Xinglin scholar proj- ect of Chengdu University of traditional Chinese medicine [YYZX2021035]
- Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University
Low expression of PCDH17 is correlated with poor prognosis in HCC patients and it affects the malignant biological behavior of HCC through regulation of DNA methylation and EMT.
Hepatocellular carcinoma (HCC) is one of the malignant tumors most frequently encountered in the clinic. Studies have shown that the abnormal expression of various genes leads to the malignant progression of tumors, and the modification in DNA methylation can cause a change in gene expression. Increasing evidence has shown that abnormal expression of PCDH17 is found in many human cancers. However, its functional role in HCC remains unexplored. Herein, we found that PCDH17 was expressed at low levels in HCC tissues and cell lines. There is a significant correlation between low expression of PCDH17 and poor prognosis of HCC patients. Increased expression of PCDH17 significantly suppressed cell proliferation, migration and invasion in HCC. The low expression of PCDH17 was due to its high DNA methylation level, and changing the expression of DNMT3B significantly affect the DNA methylation level of PCDH17 and increase its protein expression. Furthermore, methylation of PCDH17 regulated by DNMT3B affects the malignant biological behavior of HCC through EMT. In conclusion, PCDH17 participates in malignant biological behavior of HCC and that DNMT3B plays an important role in the regulation of PCDH17 methylation, which affects the malignant progression of HCC.
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