4.6 Review

Global estimates and determinants of antituberculosis drug pharmacokinetics in children and adolescents: a systematic review and individual patient data meta-analysis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

Optimizing Dosing and Fixed-Dose Combinations of Rifampicin, Isoniazid, and Pyrazinamide in Pediatric Patients With Tuberculosis: A Prospective Population Pharmacokinetic Study

Paolo Denti et al.

Summary: The dosing guidelines for childhood tuberculosis need to be revised as current pediatric FDC doses result in low rifampicin exposures. New fixed-dose combination (FDC) with revised weight bands could improve treatment for children with drug-susceptible tuberculosis.

CLINICAL INFECTIOUS DISEASES (2022)

Article Immunology

Treatment and Outcome in Children With Tuberculous Meningitis: A Multicenter Pediatric Tuberculosis Network European Trials Group Study

Stephanie Thee et al.

Summary: This European multicenter study provides data on the management and outcome of tuberculosis (TB) meningitis in children, highlighting that both morbidity and mortality remain high even in high-resource settings. Several key factors associated with unfavorable outcome were identified.

CLINICAL INFECTIOUS DISEASES (2022)

Review Medical Laboratory Technology

Therapeutic Drug Monitoring of Anti-infective Drugs: Implementation Strategies for 3 Different Scenarios

Hannah Yejin Kim et al.

Summary: Tailoring therapeutic drug monitoring (TDM) strategies to specific settings and patient groups is crucial for meeting clinical needs. Important considerations in different scenarios include turnaround time for critically ill patients, convenience of sampling for outpatients, and feasibility in settings with limited laboratory resources.

THERAPEUTIC DRUG MONITORING (2022)

Article Pediatrics

Pharmacokinetics and safety/tolerability of isoniazid, rifampicin and pyrazinamide in children and adolescents treated for tuberculous meningitis

Rovina Ruslami et al.

Summary: This study examined the pharmacokinetics and safety of isoniazid, rifampicin, and pyrazinamide in children and adolescents with tuberculous meningitis. It found that higher doses of rifampicin are needed for the treatment of TBM in this population, and that there was an association between higher plasma concentrations of isoniazid, rifampicin, and pyrazinamide and the development of drug-induced liver injury. Further confirmatory studies are needed to validate these findings.

ARCHIVES OF DISEASE IN CHILDHOOD (2022)

Article Immunology

Pharmacokinetics of First-Line Drugs in Children With Tuberculosis, Using World Health Organization-Recommended Weight Band Doses and Formulations

Chishala Chabala et al.

Summary: The fixed-dose combination tablets delivering higher doses of first-line antituberculosis drugs in children resulted in lower drug exposures, both in children with lower weights and those receiving adult doses. Further adjustments are needed to achieve target exposures in adults.

CLINICAL INFECTIOUS DISEASES (2022)

Article Immunology

Randomized Clinical Trial of High-Dose Rifampicin With or Without Levofloxacin Versus Standard of Care for Pediatric Tuberculous Meningitis: The TBM-KIDS Trial

Mandar S. Paradkar et al.

Summary: In this antibiotic treatment trial for pediatric tuberculous meningitis, children receiving high-dose rifampicin had similar functional outcomes and a trend toward better neurocognitive outcomes compared to those receiving a standard-dose rifampicin-containing regimen. Confirmation in a larger trial is needed due to the higher frequency of adverse events.

CLINICAL INFECTIOUS DISEASES (2022)

Article Infectious Diseases

Population pharmacokinetics of ethambutol in African children: a pooled analysis

Tjokosela Tikiso et al.

Summary: Population pharmacokinetics of ethambutol in children with TB were studied to guide dosing in this population. The bioavailability of ethambutol was reduced in HIV-positive children. Current doses need to be doubled to achieve the recommended blood concentration range, which raises concerns about ocular toxicity.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2022)

Article Medicine, General & Internal

Shorter Treatment for Nonsevere Tuberculosis in African and Indian Children

A. Turkova et al.

Summary: Four months of antituberculosis treatment was noninferior to 6 months of treatment in children with drug-susceptible, nonsevere, smear-negative tuberculosis.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Pharmacology & Pharmacy

The use of a modified Delphi technique to develop a critical appraisal tool for clinical pharmacokinetic studies

Alaa Bahaa Eldeen Soliman et al.

Summary: This study aimed to develop a critical appraisal tool for clinical pharmacokinetic studies by achieving experts' consensus on quality markers. After three rounds of a modified Delphi process, a 21-item tool was developed. Further studies are needed to confirm the validity and reliability of the tool.

INTERNATIONAL JOURNAL OF CLINICAL PHARMACY (2022)

Article Infectious Diseases

Enteropathogen spectrum and effect on antimycobacterial pharmacokinetics among children with tuberculosis in rural Tanzania: a prospective cohort study

Daniel Van Aartsen et al.

Summary: This study investigated the enteropathogen burden and its impact on antimycobacterial pharmacokinetics among children receiving tuberculosis treatment in rural Tanzania. The findings revealed that enteropathogen burden was common and significantly reduced the concentrations of certain antimycobacterial drugs. This study is important for further understanding the relationship between individual pathogens and antimycobacterial pharmacokinetics, as well as the potential improvement of pharmacokinetic target attainment through the treatment of enteropathogens at tuberculosis treatment initiation.

LANCET MICROBE (2022)

Article Infectious Diseases

Clinical standards for the dosing and management of TB drugs

J. W. C. Alffenaar et al.

Summary: This article presents clinical standards for dosing and management of TB drugs, aiming to guide clinicians and program managers in planning and implementing locally appropriate measures for optimal treatment and improved patient care.

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE (2022)

Article Immunology

Treatment Outcomes of Childhood Tuberculous Meningitis in a Real-World Retrospective Cohort, Bandung, Indonesia

Heda M. Nataprawira et al.

Summary: This retrospective evaluation analyzed the clinical features and outcomes of children treated for tuberculous meningitis at Hasan Sadikin Hospital in Bandung, Indonesia, from 2011 to 2020. The study found that childhood tuberculous meningitis in Indonesia leads to significant neurological sequelae and death, emphasizing the importance of improved early diagnosis, better tuberculosis prevention, and optimized management strategies.

EMERGING INFECTIOUS DISEASES (2022)

Article Medicine, General & Internal

Four-Month Rifapentine Regimens with or without Moxifloxacin for Tuberculosis

S. E. Dorman et al.

Summary: The study found that a 4-month rifapentine-based regimen containing moxifloxacin was noninferior to the standard 6-month regimen in the treatment of tuberculosis, supporting the noninferiority hypothesis. This regimen was effective in both the microbiologically eligible population and the assessable population.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Critical Care Medicine

A Rapid Pharmacogenomic Assay to Detect NAT2 Polymorphisms and Guide Isoniazid Dosing for Tuberculosis Treatment

Renu Verma et al.

Summary: Genetic testing revealed that 56.2% were predicted as slow acetylators, 33.3% as intermediate acetylators, and 10.4% as rapid acetylators. The predicted slow acetylators had the lowest INH clearance rates, followed by intermediate acetylators and rapid acetylators.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

Article Infectious Diseases

Pharmacokinetics and safety of high-dose rifampicin in children with TB: the Opti-Rif trial

Anthony J. Garcia-Prats et al.

Summary: The study evaluated the pharmacokinetics and safety of high rifampicin doses in 20 children aged 0-12 years, finding that a dose of 65-70 mg/kg of rifampicin was needed to achieve the target exposure in children.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2021)

Article Immunology

Integrating Pharmacokinetics and Pharmacodynamics in Operational Research to End Tuberculosis

Jan-Willem C. Alffenaar et al.

CLINICAL INFECTIOUS DISEASES (2020)

Article Infectious Diseases

Pharmacokinetics of First-Line Drugs Among Children With Tuberculosis in Rural Tanzania

Museveni Justine et al.

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY (2020)

Review Infectious Diseases

Pharmacokinetics of antiretroviral and tuberculosis drugs in children with HIV/TB co-infection: a systematic review

Tom G. Jacobs et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2020)

Review Pediatrics

Adolescent tuberculosis

Kathryn J. Snow et al.

LANCET CHILD & ADOLESCENT HEALTH (2020)

Article Infectious Diseases

Pharmacokinetics of isoniazid in Indian children with tuberculosis on daily treatment

I. Shah et al.

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE (2019)

Review Pharmacology & Pharmacy

A Systematic Review on the Effect of HIV Infection on the Pharmacokinetics of First-Line Tuberculosis Drugs

Alper Daskapan et al.

CLINICAL PHARMACOKINETICS (2019)

Article Infectious Diseases

Protein binding of rifampicin is not saturated when using high-dose rifampicin

Carlijn H. C. Litjens et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2019)

Article Microbiology

Protein Binding of First-Line Antituberculosis Drugs

Wael A. Alghamdi et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2018)

Article Pediatrics

Pharmacokinetic study of isoniazid and pyrazinamide in children: impact of age and nutritional status

Rajeshwar Dayal et al.

ARCHIVES OF DISEASE IN CHILDHOOD (2018)

Review Respiratory System

The incidence of tuberculosis among adolescents and young adults: a global estimate

Kathryn J. Snow et al.

EUROPEAN RESPIRATORY JOURNAL (2018)

Review Infectious Diseases

Pharmacokinetics of rifampicin in adult TB patients and healthy volunteers: a systematic review and meta-analysis

K. E. Stott et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2018)

Article Biochemistry & Molecular Biology

A patient-level pooled analysis of treatment-shortening regimens for drug-susceptible pulmonary tuberculosis

Marjorie Z. Imperial et al.

NATURE MEDICINE (2018)

Editorial Material Critical Care Medicine

Understanding PK/PD

Jason A. Roberts et al.

INTENSIVE CARE MEDICINE (2016)

Article Pharmacology & Pharmacy

A simultaneous population pharmacokinetic analysis of rifampicin in Malawian adults and children

Alessandro Schipani et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2016)

Article Infectious Diseases

Pharmacokinetics of isoniazid, rifampicin, pyrazinamide and ethambutol in HIV-infected Indian children

A. Mukherjee et al.

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE (2016)

Article Infectious Diseases

Bioavailability of two licensed paediatric rifampicin suspensions: implications for quality control programmes

H. McIlleron et al.

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE (2016)

Article Medicine, General & Internal

ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions

Jonathan A. C. Sterne et al.

BMJ-BRITISH MEDICAL JOURNAL (2016)

Article Medicine, General & Internal

ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions

Jonathan A. C. Sterne et al.

BMJ-BRITISH MEDICAL JOURNAL (2016)

Review Medicine, General & Internal

Rayyan-a web and mobile app for systematic reviews

Mourad Ouzzani et al.

SYSTEMATIC REVIEWS (2016)

Article Microbiology

Exposure to Total and Protein-Unbound Rifampin Is Not Affected by Malnutrition in Indonesian Tuberculosis Patients

L. H. M. te Brake et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)

Article Infectious Diseases

Pharmacokinetics of isoniazid, rifampicin, pyrazinamide and ethambutol in Indian children

Aparna Mukherjee et al.

BMC INFECTIOUS DISEASES (2015)

Article Pharmacology & Pharmacy

Antituberculosis Drugs in Children

H. S. Schaaf et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2015)

Article Infectious Diseases

Rifampicin pharmacokinetics in children under the Revised National Tuberculosis Control Programme, India, 2009

A. Arya et al.

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE (2015)

Review Medicine, General & Internal

Preferred Reporting Items for a Systematic Review and Meta-analysis of Individual Participant Data The PRISMA-IPD Statement

Lesley A. Stewart et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)

Article Infectious Diseases

Pharmacokinetics of anti-TB drugs in Malawian children: reconsidering the role of ethambutol

R. Mlotha et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2015)

Review Infectious Diseases

Treatment outcomes of childhood tuberculous meningitis: a systematic review and meta-analysis

Silvia S. Chiang et al.

LANCET INFECTIOUS DISEASES (2014)

Article Infectious Diseases

Age, nutritional status and INH acetylator status affect pharmacokinetics of anti-tuberculosis drugs in children

G. Ramachandran et al.

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE (2013)

Article Immunology

PYRAZINAMIDE PLASMA CONCENTRATIONS IN YOUNG CHILDREN WITH TUBERCULOSIS

Helen McIlleron et al.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2011)

Article Microbiology

Effects of Tuberculosis, Race, and Human Gene SLCO1B1 Polymorphisms on Rifampin Concentrations

Marc Weiner et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)

Review Pharmacology & Pharmacy

A systematic review of pharmacokinetics studies in children with protein-energy malnutrition

Kazeem A. Oshikoya et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2010)

Article Pharmacology & Pharmacy

Pyrazinamide blood concentrations in children suffering from tuberculosis: a comparative study at two doses

Pooja Gupta et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2008)

Article Public, Environmental & Occupational Health

Development of a WHO growth reference for school-aged children and adolescents

Mercedes de Onis et al.

BULLETIN OF THE WORLD HEALTH ORGANIZATION (2007)

Article Pediatrics

Isoniazid pharmacokinetics in children treated for respiratory tuberculosis

HS Schaaf et al.

ARCHIVES OF DISEASE IN CHILDHOOD (2005)