Intrapulmonary shunt and alveolar dead space in a cohort of patients with acute COVID-19 pneumonitis and early recovery

Background Pathological evidence suggests that coronavirus disease 2019 (COVID-19) pulmonary infection involves both alveolar damage (causing shunt) and diffuse microvascular thrombus formation (causing alveolar dead space). We propose that measuring respiratory gas exchange enables detection and quantification of these abnormalities. We aimed to measure shunt and alveolar dead space in moderate COVID-19 during acute illness and recovery.Methods We studied 30 patients (22 males; mean +/- SD age 49.9 +/- 13.5 years) 3-15 days from symptom onset and again during recovery, 55 +/- 10 days later (n=17). Arterial blood (breathing ambient air) was collected while exhaled oxygen and carbon dioxide concentrations were measured, yielding alveolar-arterial differences for each gas (PA-aO2 and Pa-ACO2, respectively) from which shunt and alveolar dead space were computed.Results For acute COVID-19 patients, group mean (range) for PA-aO2 was 41.4 (-3.5-69.3) mmHg and for Pa-ACO2 was 6.0 (-2.3-13.4) mmHg. Both shunt (% cardiac output) at 10.4% (0-22.0%) and alveolar dead space (% tidal volume) at 14.9% (0-32.3%) were elevated (normal: <5% and <10%, respectively), but not correlated (p=0.27). At recovery, shunt was 2.4% (0-6.1%) and alveolar dead space was 8.5% (0- 22.4%) (both p<0.05 versus acute). Shunt was marginally elevated for two patients; however, five patients (30%) had elevated alveolar dead space.Conclusions We speculate impaired pulmonary gas exchange in early COVID-19 pneumonitis arises from two concurrent, independent and variable processes (alveolar filling and pulmonary vascular obstruction). For most patients these resolve within weeks; however, high alveolar dead space in similar to 30% of recovered patients suggests persistent pulmonary vascular pathology.

Automated summary

This study investigated the measurement and changes of shunt and alveolar dead space in moderate COVID-19 patients during acute illness and recovery. The results showed that most patients' abnormalities resolved within weeks, but about 30% of recovered patients still had pulmonary vascular pathology.