期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 931, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ejphar.2022.175180
关键词
Transient receptor potential melastatin 7; (TRPM7); Ion channels; Channel kinase; Magnesium(Mg2+)
资金
- National Natural Science Foundation of China [81902182, 82071591]
- Natural Science Foundation Incubation Program of The Second Hospital of Anhui Medical University [2021GMFY06]
TRPM7 is a channel protein located on the cell membrane that regulates the balance of intracellular Mg2+. It plays an important role in cell proliferation, adhesion, migration, and is directly related to disease occurrence and development.
TRPM (transient receptor potential melastatin) 7, a member of the TRPM subfamily, is a nonselective cation channel located on the cell membrane that regulates mammalian cell intracellular Mg2+ balance. TRPM7 is widely expressed in vivo and is characterized by a unique domain structure comprised of cation channel and protein kinase. TRPM7 primarily controls the cellular influx of Mg2+ and Ca2+. As such TRPM7 plays an important role in the physiological processes of cell proliferation, adhesion, migration, and differentiation, as well as phenotypic transformation. Changes in TRPM7 expression and activity are directly related to diseases such as tissue fibrosis, vascular injury, as well as the occurrence and development of tumors. The structure and function of TRPM7 has been previously described, but regulation of TRPM7 has been limited to Mg2+ and laboratory pharmacological compounds. Hence, in this review, we summarized the endogenous and exogenous regulation of TRPM7, clarified its internal regulatory mechanisms and molecular signaling pathways, and emphasized the regulation of TRPM7 activity as an important target for disease treatment.
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