期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 933, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ejphar.2022.175267
关键词
COVID-19; SARS-CoV2; Natural killer cell; Cytotoxicity; Nanocurcumin
资金
- Stem Cell Research Center (SCRC) at Tabriz University of Medical Sciences, Tabriz, Iran [66469, 66470]
This study investigates the immunomodulatory effect of Nanocurcumin in COVID-19 patients. The results suggest that Nanocurcumin may significantly enhance the frequency and function of NK cells, providing a potential treatment option to improve the clinical outcome of COVID-19 patients.
The ongoing COVID-19 pandemic is still a challenging problem in the case of infection treatment. The immunomodulatory effect of Nanocurcumin was investigated in the present study in an attempt to counterbalance the immune response and improve the patients' clinical symptoms. 60 confirmed COVID-19 patients and 60 healthy controls enrolled in the study. COVID-19 patients were divided into Nanocurcumin and placebo received groups. Due to the importance of the role of NK cells in this disease, the frequency, cytotoxicity, receptor gene expression of NK cells, and serum secretion levels of inflammatory cytokines IL-10, IL-6, TNF-alpha, as well as circulating C5a as a chemotactic factor an inflammatory mediator was evaluated by flow cytometry, real-time PCR and enzymelinked immunosorbent assay in both experimental groups before and after the intervention. Given the role of measured factors in the progression and pathogenesis of COVID-19 disease, the results can help find appropriate treatments. The results of this study indicated that the Nanocurcumin could significantly increase the frequency and function of NK cells compared to the placebo-treated group. As an immunomodulatory agent, Nanocurcumin may be a helpful choice to improve NK cell function in COVID-19 patients and improve the clinical outcome of patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据