Nicorandil protects against coronary microembolization-induced myocardial injury by suppressing cardiomyocyte pyroptosis via the AMPK/ TXNIP/NLRP3 signaling pathway

Article Biochemistry & Molecular Biology

MicroRNA-136-5p protects cardiomyocytes from coronary microembolization through the inhibition of pyroptosis

Ruping Cai et al.

Summary: This study found that miR-136-5p attenuated cardiomyocyte pyroptosis in rats with coronary microembolization (CME) by upregulating PYDC1 through the ATXN1L/CIC axis.

APOPTOSIS (2022)

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Article Cardiac & Cardiovascular Systems

Rosuvastatin Alleviates Coronary Microembolization-Induced Cardiac Injury by Suppressing Nox2-Induced ROS Overproduction and Myocardial Apoptosis

Yuanyuan Cao et al.

Summary: The study found that rosuvastatin mitigates coronary microembolism (CME)-induced cardiac injury by inhibiting Nox2-induced ROS overproduction and alleviating p53/Bax/Bcl-2-dependent cardiomyocyte apoptosis.

CARDIOVASCULAR TOXICOLOGY (2022)

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Review Cardiac & Cardiovascular Systems

A fresh look at coronary microembolization

Petra Kleinbongard et al.

Summary: This article discusses the impact of coronary microembolization on myocardial infarction, pointing out the damage to the cardiovascular system caused by mechanical stress and inflammatory instability's release of particulate debris and soluble substances, as well as the importance of prevention and treatment in clinical trials.

NATURE REVIEWS CARDIOLOGY (2022)

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Article Genetics & Heredity

Possible implication of miR-142-3p in coronary microembolization induced myocardial injury via ATXN1L/HDAC3/NOL3 axis

Yuli Xu et al.

Summary: This study found that miR-142-3p attenuates myocardial injury induced by coronary microembolization (CME) through the regulation of the ATXN1L/HDAC3/NOL3 pathway. Overexpression of miR-142-3p or knockout of ATXN1L can inhibit cardiomyocyte apoptosis and pyroptosis, promoting myocardial protection.

JOURNAL OF MOLECULAR MEDICINE-JMM (2022)

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Review Cell Biology

Mitochondrial Damage in Myocardial Ischemia/Reperfusion Injury and Application of Natural Plant Products

Xin Su et al.

Summary: Ischemic heart disease (IHD) is a major cause of death in cardiovascular diseases worldwide. Mitochondrial dysfunction and structural disorders play a crucial role in the development of IHD. Natural plant products (NPPs) have shown potential in protecting cardiomyocytes during reperfusion injury by preserving mitochondrial integrity and improving mitochondrial function.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Review Cell Biology

Programmed cell death in atherosclerosis and vascular calcification

Min Li et al.

Summary: The concept of cell death has expanded to include various forms such as necroptosis, pyroptosis, autophagy, and ferroptosis, in addition to apoptosis and necrosis. These different modes of cell death play critical roles in all aspects of life and have diverse implications in diseases. Atherosclerosis (AS) and vascular calcification (VC) are major causes of high morbidity and mortality in cardiovascular disease. Despite advancements in understanding the signaling pathways associated with AS and VC, the exact molecular basis remains unknown. This article reviews the molecular mechanisms underlying cell death and its implications for AS and VC, which may lead to the development of promising therapeutic strategies.

CELL DEATH & DISEASE (2022)

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Article Cardiac & Cardiovascular Systems

Long non-coding RNA Sox2OT promotes coronary microembolization-induced myocardial injury by mediating pyroptosis

Liying Xuan et al.

Summary: This study aimed to evaluate the role of lncRNA Sox2 overlapping transcript (Sox2OT) in coronary microembolization-induced myocardial injury (MI). The results showed that silencing Sox2OT inhibited MI by eliminating Sox2OT/miR-23b binding and down-regulating the TLR4/NF-kappa B pathway.

ESC HEART FAILURE (2022)

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Article Biochemistry & Molecular Biology

Relaxin Inhibits the Cardiac Myofibroblast NLRP3 Inflammasome as Part of Its Anti-Fibrotic Actions via the Angiotensin Type 2 and ATP (P2X7) Receptors

Felipe Tapia Caceres et al.

Summary: The study reveals the broader extent to which recombinant human relaxin targets the myofibroblast NLRP3 inflammasome to mediate its anti-fibrotic effects.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Integrative & Complementary Medicine

Geniposide suppresses NLRP3 inflammasome-mediated pyroptosis via the AMPK signaling pathway to mitigate myocardial ischemia/reperfusion injury

Haiyan Li et al.

Summary: This study found that geniposide can significantly inhibit NLRP3 inflammasome activation via the AMPK signaling pathway and inhibit pyroptosis of cardiomyocytes. Geniposide has a cardioprotective effect, reducing myocardial infarction size, improving heart function, and suppressing inflammatory response. Additionally, geniposide promotes cellular energy metabolism and reduces oxidative stress levels.

CHINESE MEDICINE (2022)

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Article Medicine, Research & Experimental

Gasdermin D inhibition confers antineutrophil-mediated cardioprotection in acute myocardial infarction

Kai Jiang et al.

Summary: The study identified GSDMD in activated leukocytes in the infarcted heart, showing that loss of GSDMD reduces infarct size, improves cardiac function, and increases survival after acute myocardial infarction. Excessive bone marrow-derived and GSDMD-dependent early neutrophil production and mobilization contribute to detrimental immunopathology after AMI. Pharmacological inhibition of GSDMD provides cardioprotection by reducing scar size and enhancing heart function post-AMI.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Cell Biology

Rosuvastatin protects against coronary microembolization-induced cardiac injury via inhibiting NLRP3 inflammasome activation

Ao Chen et al.

Summary: In this study, it was found that the NLRP3 inflammasome plays an important role in CME-induced cardiac injury, and treatment with rosuvastatin (RVS) can improve cardiac function, reduce damage, and lower ROS levels.

CELL DEATH & DISEASE (2021)

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Review Nutrition & Dietetics

Cardiac Oxidative Stress and the Therapeutic Approaches to the Intake of Antioxidant Supplements and Physical Activity

Kosar Valaei et al.

Summary: Reactive oxygen species (ROS) play a crucial role in the pathophysiology of cardiac diseases, leading to cellular and molecular disorders that can result in heart dysfunction. New experimental treatments such as creatine supplementation, omega-3 fatty acids, and others have shown beneficial effects in improving oxidative stress.

NUTRIENTS (2021)

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Review Biochemistry & Molecular Biology

AMPK, metabolism, and vascular function

Claudia Rodriguez et al.

Summary: AMPK serves as a crucial cellular energy sensor activated during energy stress, playing a key role in maintaining energy homeostasis. It is involved in various functions such as mitochondrial biogenesis, redox regulation, cell growth, autophagy, and inflammation. Recent studies have highlighted the protective role of AMPK in cardiovascular function and its association with cardiovascular disease pathogenesis.

FEBS JOURNAL (2021)

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Article Biochemistry & Molecular Biology

AMP-activated protein kinase: A remarkable contributor to preserve a healthy heart against ROS injury

Alice Marino et al.

Summary: Heart failure is a major cause of death and disability globally, with left ventricular remodeling, fibrosis, and ischemia/reperfusion injury contributing to cardiac dysfunction. AMPK acts as a universal energy sensor in response to low ATP levels, playing a crucial role in the heart. Excessive reactive oxygen species can activate AMPK, providing an additional role as a redox sensor for preventing heart failure progression.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Review Pharmacology & Pharmacy

Gasdermin D in pyroptosis

Brandon E. Burdette et al.

Summary: Pyroptosis is a process of inflammatory cell death that defends the host against microbe infection, but excessive pyroptosis can lead to inflammatory diseases. The cleavage of GsdmD is essential for pyroptosis, releasing cytokines and causing cell death, playing a crucial role in inflammatory diseases.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Immunology

NLRP3 inflammasome activation and cell death

Yi Huang et al.

Summary: The NLRP3 inflammasome is a cytosolic multiprotein complex that responds to microbial infection, endogenous danger signals, and environmental stimuli. Its activation can induce pyroptosis and release of inflammatory cytokines, contributing to innate immune defense. However, aberrant activation of the NLRP3 inflammasome is associated with inflammatory diseases, and there is a close relationship between cell death pathways and NLRP3 inflammasome activation.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Editorial Material Cardiac & Cardiovascular Systems

Multiple Cell Death Programs Contribute to Myocardial Infarction

Xiaotong F. Jia et al.

CIRCULATION RESEARCH (2021)

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Article Cardiac & Cardiovascular Systems

GSDMD-Mediated Cardiomyocyte Pyroptosis Promotes Myocardial I/R Injury

Huairui Shi et al.

Summary: The study demonstrates the significant role of GSDMD-mediated cardiomyocyte pyroptosis in myocardial I/R injury, and suggests that the caspase-11/GSDMD pathway may be essential to this process. Furthermore, GSDMD inhibition significantly reduces cardiomyocyte pyroptosis and I/R-induced myocardial injury.

CIRCULATION RESEARCH (2021)

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Article Cardiac & Cardiovascular Systems

Effects of Intracoronary Nicorandil on Myocardial Microcirculation and Clinical Outcomes in Patients with Acute Myocardial Infarction: A Meta-Analysis of Randomized Controlled Trials

Liye Shi et al.

AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS (2020)

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Article Peripheral Vascular Disease

Nicorandil for Periprocedural Myocardial Injury in Elective Percutaneous Coronary Intervention: A Meta-Analysis of 10 Randomized Controlled Trials

Bin Yi et al.

ANGIOLOGY (2020)

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Article Biochemistry & Molecular Biology

NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy

Cheng Zeng et al.

REDOX BIOLOGY (2020)

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Article Pharmacology & Pharmacy

AMP-activated protein kinase: An attractive therapeutic target for ischemia-reperfusion injury

Rong Ding et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Letter Cardiac & Cardiovascular Systems

Nicorandil, a promising drug for the prevention of percutaneous coronary artery intervention-related myocardial injury and infarction in patients with stable coronary artery disease

Yiqi Zhang et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2020)

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Review Biochemistry & Molecular Biology

The AMP-Activated Protein Kinase Plays a Role in Antioxidant Defense and Regulation of Vascular Inflammation

Thomas Jansen et al.

ANTIOXIDANTS (2020)

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Article Chemistry, Medicinal

Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes

Bozhi Ye et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2019)

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Article Endocrinology & Metabolism

Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes

Zhen Qiu et al.

JOURNAL OF DIABETES RESEARCH (2019)

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Article Cell Biology

Nicorandil alleviates apoptosis in diabetic cardiomyopathy through PI3K/Akt pathway

Xuyang Wang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Article Endocrinology & Metabolism

Exendin-4 Protects against Hyperglycemia-Induced Cardiomyocyte Pyroptosis via the AMPK-TXNIP Pathway

Hong Wei et al.

JOURNAL OF DIABETES RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Liraglutide attenuates NLRP3 inflammasome-dependent pyroptosis via regulating SIRT1/NOX4/ROS pathway in H9c2 cells

Ao Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Cardiac & Cardiovascular Systems

Periprocedural myocardial infarction and injury in elective coronary stenting

Michel Zeitouni et al.

EUROPEAN HEART JOURNAL (2018)

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Article Cardiac & Cardiovascular Systems

Coronary microembolization and microvascular dysfunction

Gerd Heusch et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2018)

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Review Biochemistry & Molecular Biology

The role of mitochondria in cardiac development and protection

Jaakko L. Pohjoismaki et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

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Article Biochemistry & Molecular Biology

Nicorandil modulated macrophages activation and polarization via NF-κb signaling pathway

Fengyun Zhang et al.

MOLECULAR IMMUNOLOGY (2017)

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Article Multidisciplinary Sciences

Doxorubicin-induced oxidative stress: The protective effect of nicorandil on HL-1 cardiomyocytes

Mari C. Asensio-Lopez et al.

PLOS ONE (2017)

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Review Cardiac & Cardiovascular Systems

AMP-Activated Protein Kinase An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System

Ian P. Salt et al.

CIRCULATION RESEARCH (2017)

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Review Pharmacology & Pharmacy

Emerging drugs for the treatment of angina pectoris

Cher-Rin Chong et al.

EXPERT OPINION ON EMERGING DRUGS (2016)

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Article Cardiac & Cardiovascular Systems

AMPK is critical for mitochondrial function during reperfusion after myocardial ischemia

Vlad G. Zaha et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2016)

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Article Pharmacology & Pharmacy

Ilexgenin A inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK dependent manner

Yi Li et al.

PHARMACOLOGICAL RESEARCH (2015)

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Article Cardiac & Cardiovascular Systems

TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury

Yi Liu et al.

BASIC RESEARCH IN CARDIOLOGY (2014)

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Article Endocrinology & Metabolism

Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet

Islam N. Mohamed et al.

DIABETOLOGIA (2014)

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Article Biochemistry & Molecular Biology

AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1

Ning Wu et al.

MOLECULAR CELL (2013)

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Article Multidisciplinary Sciences

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou et al.

NATURE (2011)

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Article Cardiac & Cardiovascular Systems

5-Year Prognostic Value of No-Reflow Phenomenon After Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction

Gjin Ndrepepa et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2010)

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Article Immunology

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

Rongbin Zhou et al.

NATURE IMMUNOLOGY (2010)

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Article Immunology

NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?

Jurg Tschopp et al.

NATURE REVIEWS IMMUNOLOGY (2010)

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Article Cardiac & Cardiovascular Systems

Impact of microvascular dysfunction on left ventricular remodeling and long-term clinical outcome after primary coronary angioplasty for acute myocardial infarction

L Bolognese et al.

CIRCULATION (2004)

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Nicorandil protects against coronary microembolization-induced myocardial injury by suppressing cardiomyocyte pyroptosis via the AMPK/ TXNIP/NLRP3 signaling pathway

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