Kinetic and Dynamic Kinetic Resolution by Dual Catalysis

Kinetic resolution is one of the most common methods to access enantiomerically enriched compounds. In this method, the resolution is based on the existing difference in reaction rates of the two enantiomers with a chiral catalyst. In the dynamic kinetic resolution, the less reactive enantiomer is racemized and the racemic mixture is further resolved, leading eventually to complete transformation to an enantioenriched compound. This review summarizes the dual catalytic strategies (i. e., modular combinations of distinct catalysts) that have been applied to kinetic resolution and dynamic kinetic resolution. We focus upon the role of the two catalysts, the compatibility between them, and the practical benefits.

Automated summary

Kinetic resolution and dynamic kinetic resolution are common methods to access enantiomerically enriched compounds, with the latter achieving complete transformation through the process of racemization and further resolution. This review summarizes the dual catalytic strategies applied in kinetic resolution and dynamic kinetic resolution, focusing on the role of the two catalysts, compatibility between them, and practical benefits.