期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 26, 期 7, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202201176
关键词
Deoxygenation; Heterocycles; Minisci-type reaction; Radical reactions
In this study, a simple strategy for synthesizing fused heterocycles through a deoxygenative, intramolecular Minisci-type reaction is presented. This method allows for the generation of complex polycyclic scaffolds in just three steps using easily accessible starting materials such as chlorinated heteroarenes and 1,3-diols. By using saccharide derivatives as the starting 1,3-diol motif, novel heterocyclic scaffolds with excellent diastereoselectivity and formal retention of configuration at the newly formed C -C bond can be obtained.
Herein, we present a straightforward strategy for the synthesis of fused heterocycles through a deoxygenative, intramolecular Minisci-type reaction. This approach grants access to complex polycyclic scaffolds in three steps from readily available starting materials, such as chlorinated heteroarenes and 1,3-diols. The use of saccharide derivatives as the starting 1,3-diol motif allows for the synthesis of novel heterocyclic scaffolds with excellent diastereoselectivity and formal retention of configuration at the newly formed C -C bond.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据