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Review
Neurosciences
Devargya Ganguly et al.
Summary: EphA-4 plays a significant role in the onset and progression of Alzheimer's disease. Inhibition of EphA-4 can alleviate symptoms and affect the development of the disease. Further research on the regulation pathways of EphA-4 and the development of therapeutic methods targeting its enzymatic activity are important.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Kubra Celik Topkara et al.
Summary: Carvacrol, a multi-target pharmacological agent, shows promising therapeutic effects in the treatment of Alzheimer's disease by enhancing cell viability, reducing oxidative stress, and improving cognitive impairment. Through experiments, it was found to effectively prevent beta-amyloid-induced neurotoxicity and memory deficits.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
David Foxe et al.
Summary: This study found distinct profiles in behavior, mood, and functional capacity among different variants of Primary Progressive Aphasia (PPA), which go beyond the primary language disorder. Caregivers of semantic variant PPA reported greater behavioral disturbances than other variants, with memory problems also more severe in semantic and logopenic variants compared to non-fluent variant. These findings have important implications for clinical management and caregiver education in PPA.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Jeffrey Cummings et al.
Summary: Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) commonly co-occur. Animal models suggest that chronic low-grade inflammation caused by persistent hyperglycemia may contribute to the development of neuroinflammation and accelerate the pathobiology of AD. Epidemiological studies show that T2DM patients treated with specific anti-diabetic agents have a decreased risk for AD.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
Javier Maria Peralta Ramos et al.
Summary: The incidence of age-related dementia is increasing, but there are currently no effective treatments available. Recent studies have shown that the immune system plays a crucial role in supporting brain maintenance and repair, and modulating immune cell fate may be a potential therapeutic target for combating brain aging and neurodegeneration.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Guy Cheron et al.
Summary: Alzheimer's disease is characterized by amyloid deposits and neurofibrillary tangles in the brain. This study investigates the electrophysiological behavior of the cerebellum in a mouse model of Alzheimer's disease, and suggests that alterations in Purkinje cells and deep cerebellar nuclei neurons may explain the behavioral deficits observed. The study also finds the presence of beta-amyloid deposits in the cerebellum.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
Rahul Kumar et al.
Summary: This article discusses the role of Pyk2 in the pathogenesis of Alzheimer's disease and its potential as a therapeutic drug.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
Arpita Bera et al.
Summary: This article discusses the role of Drp1 in the pathogenesis of Alzheimer's disease and the potential of Drp1 inhibitors as therapeutic drugs for AD in the future.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Sophia Haberstumpf et al.
Summary: Poor performance in cognitive abilities, particularly in declarative memory and visual-spatial processing, is associated with a higher likelihood of dropping out of long-term studies in the elderly population. Additionally, lower cognitive performance is predictive of dropout behavior, potentially leading to a bias towards healthier individuals over time.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
Mai M. Anwar et al.
Summary: The blood-brain barrier (BBB) is a crucial protective barrier for the highly vascularized brain tissue, consisting of components like endothelial cells, astrocytes, and pericytes that provide essential blood supply and nutrients. In Alzheimer's disease, long-term neuroinflammatory cascades may lead to BBB dysfunction and altered extracellular matrix components, impacting brain function.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
Elizabeth Drinkwater et al.
Summary: Social isolation is a potentially modifiable lifestyle factor associated with Alzheimer's disease. Research suggests that social isolation may be linked to the development of Alzheimer's disease.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
Anusha Jayaraman et al.
Summary: Necroptosis, a non-apoptotic cell death pathway, plays a significant role in Alzheimer's disease by involving multiple molecular mechanisms that interact and contribute to cellular vulnerability at different disease stages. Targeting these diverse pathways for therapeutic intervention remains a challenge due to their complex synergistic or inhibitory effects on each other.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
Tyler S. Saunders et al.
Summary: This systematic review evaluates the association between cerebrospinal fluid protein markers and cognition in neurodegenerative dementias. Some evidence suggests a correlation between certain markers and worse cognition in Alzheimer's disease, frontotemporal dementia, and typical cognitive ageing. However, due to the substantial heterogeneity between studies, no firm conclusions can be drawn. Future research should focus on improving standardization and reporting, as well as investigating the significance of novel markers.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
Udaysankar Chockanathan et al.
Summary: In this review, the importance of neural circuit research in Alzheimer's disease (AD) is discussed, with emphasis on synapses and network activity and how they contribute to our understanding of the disease process.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
Oliver George Steele et al.
Summary: The APOE gene is the most significant genetic risk factor for late-onset Alzheimer's disease, with the APOE4 genotype being associated with neuropathological and cognitive deficits. It has been proposed that APOE4 leads to cerebral dysfunction through various mechanisms, including neurodegeneration, neurovascular dysfunction, neuroinflammation, and oxidative stress. Further study is needed to understand the complex interplay between APOE4 and these mechanisms and their impact on brain function.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Anna J. Stevenson et al.
Summary: The study found differences between blood-based inflammation and ageing-related DNA methylation patterns and brain-based patterns, depending on the evaluated regions. The highest epigenetic age acceleration was observed in the hippocampus, while inflammation-related DNA methylation signatures did not vary significantly across brain regions. Reactive microglial burdens were highest in the hippocampus, but the only association between blood- and brain-based methylation signatures and microglia was a significant positive association with acceleration of one epigenetic clock averaged over all five brain regions.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Alexandria D. Samson et al.
Summary: This study explored the prevalence of seven established MCI risk categories among older adults with and without MCI. The results showed that neuropsychological risk categories had the largest differences between groups, and age, gender, and education were identified as important risk factors for MCI. Additionally, CSF tau levels were correlated with ApoE4 carrier status, age, and a decrease in daily activities.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Sydney M. A. Juan et al.
Summary: Repetitive mild traumatic brain injury may contribute to the development of neurodegenerative conditions. This study found that repetitive brain injury caused neurobehavioral deficits, gait impairments, anxiety-like behavior, and neuronal loss in mice. It also identified biochemical changes that may be involved in the onset of neurodegeneration.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Chiara Avancini et al.
Summary: This study characterized the electrophysiological markers of local and global predictive processes in individuals with Down's syndrome. The results showed that the predictive processes of auditory violation detection are preserved in individuals with Down's syndrome, but the sensitivity to local deviancies decreases with age. However, these electrophysiological markers did not predict subsequent cognitive decline in Down's syndrome patients.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Mariana Fernandes et al.
Summary: Patients with late-onset epilepsy and unknown aetiology (LOEU) exhibit significant cognitive impairment, abnormal cerebral glucose consumption, and altered cerebrospinal fluid (CSF) biomarkers associated with Alzheimer's disease. Additionally, these patients demonstrate progressive cognitive decline over time, while verbal fluency remains relatively preserved.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Editorial Material
Medicine, General & Internal
Gil D. Rabinovici
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Medicine, General & Internal
Gill Livingston et al.
