4.7 Article

Amlexanox-modified platinum(IV) complex triggers apoptotic and autophagic bimodal death of cancer cells

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

19F NMR Allows the Investigation of the Fate of Platinum(IV) Prodrugs in Physiological Conditions

Siming Yuan et al.

Summary: Pt-IV prodrugs can overcome resistance and side effects of conventional Pt-II anticancer therapies by efficiently promoting the two electrons reduction of Pt-IV to Pt-II. The activation of Pt-FBA is highly dependent upon the type of cancer cells, and FBA can shuttle out of the cell after Pt-FBA is reduced intracellularly. The F-19 NMR approach has the advantage of avoiding the interference of all background signals when investigating the activation of Pt-IV prodrugs.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Article Biochemistry & Molecular Biology

Mitochondria-targeted Pt(IV) prodrugs conjugated with an aggregation-induced emission luminogen against breast cancer cells by dual modulation of apoptosis and autophagy inhibition

Yan Su et al.

Summary: ACPt, a theranostic anticancer agent, demonstrated superior anticancer performance by modulating apoptosis and autophagy inhibition. It induced increased ROS, decreased MMP, damaged mitochondrial morphology and function, and inhibited both mitochondrial and glycolytic bioenergetics. Additionally, ACPt showed excellent anti-proliferation activity in 3D multicellular tumor spheroids, indicating potential for inhibiting solid tumors in vivo.

JOURNAL OF INORGANIC BIOCHEMISTRY (2022)

Article Chemistry, Medicinal

DNA-Unresponsive Platinum(II) Complex Induces ERS-Mediated Mitophagy in Cancer Cells

Yan Guo et al.

Summary: Mono-Pt kills cancer cells through a mitophagic pathway by stimulating endoplasmic reticulum stress and activating the unfolded protein response, severely impairing mitochondrial structure and function.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

Article Chemistry, Multidisciplinary

Activatable Mitochondria-Targeting Organoarsenic Prodrugs for Bioenergetic Cancer Therapy

Xiangjie Luo et al.

Summary: The article introduces a new bioenergetic approach for treating cancer by constructing activatable mitochondria-targeting organoarsenic prodrugs, which synergistically promote mitochondrial ROS production and induce mitochondrial DNA damage to induce apoptosis in cancer cells. In vitro and in vivo experiments demonstrate the excellent anticancer efficacy of these prodrugs, highlighting the promising outlook of this strategy for effective cancer therapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Chemistry, Medicinal

Targeting ROS-AMPK pathway by multiaction Platinum(IV) prodrugs containing hypolipidemic drug bezafibrate

Xin Qiao et al.

Summary: Lipid metabolism alterations are recognized as a hallmark for cancer, and modifying cisplatin with the hypolipidemic drug bezafibrate has resulted in enhanced anticancer activity with lower toxicity to normal cells. The novel platinum-based agents show mechanistically distinct antitumor action compared to conventional platinum drugs, indicating a potential novel strategy for cancer treatment.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

The multifaceted roles of mitochondria at the crossroads of cell life and death in cancer

Fabrizio Fontana et al.

Summary: Mitochondria in cancer cells undergo unique functional and structural dynamics, contributing to the balance between cell survival and death through metabolic rewiring, gene mutations, oxidative stress, and regulation of apoptotic proteins. The dynamic alterations in mitochondrial dynamics serve as effective biomarkers of tumor progression and potential targets for anticancer strategies.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Review Biochemistry & Molecular Biology

Pt(IV) Prodrugs with NSAIDs as Axial Ligands

Daniil Spector et al.

Summary: This review summarizes the research on the development of Pt(IV) prodrugs with NSAIDs as axial ligands, their cytotoxic action and anti-inflammatory activity mechanism studies, structure-activity ratio, and therapeutic efficacy. The chemo-anti-inflammatory strategy aims to efficiently deliver cytotoxic metabolites and NSAIDs intracellularly in tumor cells to reduce side effects and increase therapeutic efficacy. Studies have shown high therapeutic efficacy both in vitro and in vivo.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell Biology

δ-Tocotrienol sensitizes and re-sensitizes ovarian cancer cells to cisplatin via induction of G1 phase cell cycle arrest and ROS/MAPK-mediated apoptosis

Fabrizio Fontana et al.

Summary: The study found that Vitamin E-derived delta-tocotrienol can induce G1 phase cell cycle arrest and mitochondrial apoptosis in ovarian cancer cells. Additionally, the proapoptotic activity of delta-TT was found to be correlated with mitochondrial ROS production and subsequent activation of JNK and p38. Furthermore, it was observed that delta-TT can synergize with cisplatin, enhancing its cytotoxicity and re-sensitizing ovarian cancer cells to its anti-tumor effects.

CELL PROLIFERATION (2021)

Review Cell Biology

Autophagy is a major metabolic regulator involved in cancer therapy resistance

Laura Poillet-Perez et al.

Summary: Autophagy plays a crucial role in maintaining cellular homeostasis and metabolism in various diseases, including cancer. It can promote tumor growth through regulating cancer metabolism and resistance to therapy. Understanding the mechanisms of autophagy in tumor growth and resistance regulation is essential for advancing patient treatment strategies.

CELL REPORTS (2021)

Review Cell Biology

Calcium Signaling Regulates Autophagy and Apoptosis

Pramod Sukumaran et al.

Summary: Calcium serves as a crucial second messenger in regulating various physiological functions, such as cell growth/development, cell survival, and programmed cell death processes. The homeostasis of cytosolic calcium levels, maintained through coordination of proteins/pumps/Ca2+ channels and Ca2+ storage in organelles, is essential for cellular functions. Store operated Ca2+ entry (SOCE) mechanism, activated by calcium depletion, influences functions in both excitable and non-excitable cells, with potential implications in neurodegenerative conditions.
Article Chemistry, Medicinal

Cell Survival and Cell Death at the Intersection of Autophagy and Apoptosis: Implications for Current and Future Cancer Therapeutics

Nicole Bata et al.

Summary: Autophagy and apoptosis are functionally distinct mechanisms for cytoplasmic and cellular turnover, but they can also regulate each other and are influenced by upstream stress-inducing signaling pathways. The crosstalk between autophagy and apoptosis is integral in pathological processes, including cancer, homeostasis, and aging. Targeting the autophagy pathway in combination with apoptosis-inducing compounds may be a promising strategy for cancer therapy.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2021)

Review Oncology

Autophagy Regulates Stress Responses, Metabolism, and Anticancer Immunity

Eileen White et al.

Summary: Autophagy is an intracellular pathway that scavenges nutrients through degradation of proteins and organelles, contributing to survival and inflammation control. In cancer, upregulated autophagy supports growth by providing nutrients and suppressing immune responses, as well as conferring resistance to therapy.

TRENDS IN CANCER (2021)

Review Cell Biology

Mitochondria as playmakers of apoptosis, autophagy and senescence

Marianna Abate et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2020)

Review Cell Biology

Mitochondria as multifaceted regulators of cell death

Florian J. Bock et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

The Specific IKKε/TBK1 Inhibitor Amlexanox Suppresses Human Melanoma by the Inhibition of Autophagy, NF-κB and MAP Kinase Pathways

Moritz Moeller et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Medicine, General & Internal

Autophagy in Human Diseases

Noboru Mizushima et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Chemistry, Inorganic & Nuclear

Mitochondria-targeting monofunctional platinum(ii)-lonidamine conjugates for cancer cell de-energization

Nafees Muhammad et al.

INORGANIC CHEMISTRY FRONTIERS (2020)

Review Biochemistry & Molecular Biology

Various Aspects of Calcium Signaling in the Regulation of Apoptosis, Autophagy, Cell Proliferation, and Cancer

Simone Patergnani et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Chemistry, Multidisciplinary

Restraining Cancer Cells by Dual Metabolic Inhibition with a Mitochondrion-Targeted Platinum(II) Complex

Kun Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Article Chemistry, Inorganic & Nuclear

Targeting Energy Metabolism by a Platinum(IV) Prodrug as an Alternative Pathway for Cancer Suppression

Suxing Jin et al.

INORGANIC CHEMISTRY (2019)

Article Chemistry, Inorganic & Nuclear

Enhancing Cytotoxicity of a Monofunctional Platinum Complex via a Dual-DNA-Damage Approach

Yan Guo et al.

INORGANIC CHEMISTRY (2019)

Review Chemistry, Multidisciplinary

Stimuli-Responsive Therapeutic Metallodrugs

Xiaohui Wang et al.

CHEMICAL REVIEWS (2019)

Review Cell Biology

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

Rumani Singh et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Chemistry, Inorganic & Nuclear

A platinum(iv) prodrug to defeat breast cancer through disrupting vasculature and inhibiting metastasis

Yan Guo et al.

DALTON TRANSACTIONS (2019)

Article Cell Biology

The two Dictyostelium discoideum autophagy 8 proteins have distinct autophagic functions

Susanne Messling et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2017)

Review Biotechnology & Applied Microbiology

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

Lorenzo Galluzzi et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Review Oncology

Targeting autophagy in cancer

Jean M. Mulcahy Levy et al.

NATURE REVIEWS CANCER (2017)

Article Chemistry, Multidisciplinary

A Platinum(IV) Anticancer Prodrug Targeting Nucleotide Excision Repair To Overcome Cisplatin Resistance

Zhigang Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Review Chemistry, Multidisciplinary

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

Timothy C. Johnstone et al.

CHEMICAL REVIEWS (2016)

Article Biochemistry & Molecular Biology

The protein disulfide isomerases PDIA4 and PDIA6 mediate resistance to cisplatin-induced cell death in lung adenocarcinoma

G. Tufo et al.

CELL DEATH AND DIFFERENTIATION (2014)

Article Medicine, Research & Experimental

The Role of Calcium Stores in Apoptosis and Autophagy

S. S. Smaili et al.

CURRENT MOLECULAR MEDICINE (2013)

Article Chemistry, Multidisciplinary

Selective Detection and Inhibition of Active Caspase-3 in Cells with Optimized Peptides

Chris J. Vickers et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Article Chemistry, Multidisciplinary

Gemcitabine-Coumarin-Biotin Conjugates: A Target Specific Theranostic Anticancer Prodrug

Sukhendu Maiti et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Article Biochemistry & Molecular Biology

Pt(IV) complexes as prodrugs for cisplatin

Yi Shi et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2012)

Review Biochemistry & Molecular Biology

Molecular mechanisms of cisplatin resistance

L. Galluzzi et al.

ONCOGENE (2012)

Review Multidisciplinary Sciences

Autophagy in immunity and inflammation

Beth Levine et al.

NATURE (2011)

Review Oncology

Autophagy as a target for anticancer therapy

Filip Janku et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2011)

Article Biochemistry & Molecular Biology

Methods in Mammalian Autophagy Research

Noboru Mizushima et al.

Review Oncology

Biochemical Mechanisms of Cisplatin Cytotoxicity

Victoria Cepeda et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2007)

Review Pharmacology & Pharmacy

Amlexanox for the treatment of recurrent aphthous ulcers

J Bell

CLINICAL DRUG INVESTIGATION (2005)