相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonists
Shi Hou et al.
BIOORGANIC CHEMISTRY (2020)
Synthesis, antibacterial evaluation and molecular docking studies of novel series of acridone-1,2,3-triazole derivatives
Mohammed Aarjane et al.
STRUCTURAL CHEMISTRY (2020)
Utilizing Genome-Wide mRNA Profiling to Identify the Cytotoxic Chemotherapeutic Mechanism of Triazoloacridone C-1305 as Direct Microtubule Stabilization
Jaroslaw Kroliczewski et al.
CANCERS (2020)
Synthesis of novel xanthone and acridone carboxamides with potent antiproliferative activities
Antonios Georgakopoulos et al.
ARABIAN JOURNAL OF CHEMISTRY (2020)
Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells
Magdalena Niemira et al.
BIOMEDICINES (2020)
Synthesis of novel cytotoxic tetracyclic acridone derivatives and study of their molecular docking, ADMET, QSAR, bioactivity and protein binding properties
Rajkumar Veligeti et al.
SCIENTIFIC REPORTS (2020)
DHFR Inhibitors: Reading the Past for Discovering Novel Anticancer Agents
Maria Valeria Raimondi et al.
MOLECULES (2019)
Probing the Inhibition of Microtubule Affinity Regulating Kinase 4 by N-Substituted Acridones
Maria Voura et al.
SCIENTIFIC REPORTS (2019)
Assessment of DNA Topoisomerase I Unwinding Activity, Radical Scavenging Capacity, and Inhibition of Breast Cancer Cell Viability of N-alkyl-acridones and N,N-dialkyl-9,9-biacridylidenes
Marios G. Krokidis et al.
BIOMOLECULES (2019)
Structural tuning of acridones for developing anticancer agents targeting dihydrofolate reductase
Harpreet Singh et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)
Targeting tyrosine kinase: Development of acridone - pyrrole - oxindole hybrids against human breast cancer
Manpreet Kaur et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)
Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods
J. Ferlay et al.
INTERNATIONAL JOURNAL OF CANCER (2019)
Inhibit or Evade Multidrug Resistance P-Glycoprotein in Cancer Treatment
Deepali Waghray et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
New limonophyllines A-C from the stem of Atalantia monophylla and cytotoxicity against cholangiocarcinoma and HepG2 cell lines
Aonnicha Sombatsri et al.
ARCHIVES OF PHARMACAL RESEARCH (2018)
Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches
Wei Hu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
An Update on Circumventing Multidrug Resistance in Cancer by Targeting P-Glycoprotein
Xiaoqian Yang et al.
CURRENT CANCER DRUG TARGETS (2018)
Acridone alkaloids alkaloids from the stem bark of Citrus aurantium display selective cytotoxicity against breast, liver, lung and prostate human carcinoma cells
Peter A. Segun et al.
JOURNAL OF ETHNOPHARMACOLOGY (2018)
Combing metabolomics with bioanalysis methods to study the antitumor mechanism of the new acridone derivative 8q on CCRF-CEM cells: 8q induced mitochondrial-mediated apoptosis and targeted the PI3K/AKT/FOXO1 pathway
Ning Wang et al.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2018)
Medicinal chemistry of acridine and its analogues
Parteek Prasher et al.
MEDCHEMCOMM (2018)
Novel multi-substituted benzyl acridone derivatives as survivin inhibitors for hepatocellular carcinoma treatment
Bin Zhang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Acridone-pyrimidine hybrids-design, synthesis, cytotoxicity studies in resistant and sensitive cancer cells and molecular docking studies
Manikanta Murahari et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Design, synthesis, biological evaluation, molecular docking and QSAR studies of 2,4-dimethylacridones as anticancer agents
Manikanta Murahari et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer
Prashant Joshi et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Amino acid or peptide conjugates of acridine/acridone and quinoline/quinolone-containing drugs. A critical examination of their clinical effectiveness within a twenty-year timeframe in antitumor chemotherapy and treatment of infectious diseases
Monika Kukowska
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)
C-1311 (Symadex), a potential anti-cancer drug, intercalates into DNA between A and G moieties. NMR-derived and MD-refined stereostructure of the d(GAGGCCTC)2:C-1311 complex
Tomasz Laskowski et al.
JOURNAL OF MOLECULAR STRUCTURE (2017)
Evolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms
Kristoffer Soberg et al.
PLOS ONE (2017)
Recent developments in the synthesis and biological activity of acridine/acridone analogues
Monika Gensicka-Kowalewska et al.
RSC ADVANCES (2017)
Nitric oxide releasing acridone carboxamide derivatives as reverters of doxorubicin resistance in MCF7/Dx cancer cells
V. V. S. Rajendra Prasad et al.
BIOORGANIC CHEMISTRY (2016)
AKT in cancer: new molecular insights and advances in drug development
Prabhjot S. Mundi et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2016)
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade
Zhaolin Chen et al.
CANCER LETTERS (2016)
Exposure of CCRF-CEM cells to acridone derivative 8a triggers tumor death via multiple mechanisms
Yini Wang et al.
PROTEOMICS (2016)
Acridone-based Antitumor Agents: A Mini-review
Wesam S. Alwan et al.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2015)
Identification of amino acid appended acridines as potential leads to anti-cancer drugs
Palwinder Singh et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
Synthesis and antiproliferative activity of 2,7-diamino l0-(3,5-dimethoxy)benzyl-9(10H)-acridone derivatives as potent telomeric G-quadruplex DNA ligands
Chunmei Gao et al.
BIOORGANIC CHEMISTRY (2015)
Conformational Equilibrium of CDK/Cyclin Complexes by Molecular Dynamics with Excited Normal Modes
Nicolas Floquet et al.
BIOPHYSICAL JOURNAL (2015)
MRP1 and its role in anticancer drug resistance
Jamie F. Lu et al.
DRUG METABOLISM REVIEWS (2015)
Molecular design, synthesis and biological research of novel pyridyl acridones as potent DNA-binding and apoptosis-inducing agents
Bin Zhang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)
The Role of Multidrug Resistance Efflux Pumps in Cancer: Revisiting a JNCI Publication Exploring Expression of the MDR1 (P-glycoprotein) Gene
Michael M. Gottesman et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)
Design, synthesis, in vitro cytotoxic activity evaluation, and apoptosis-induction study of new 9(10H)-acridinone-1,2,3-triazoles
Maryam Mohammadi-Khanaposhtani et al.
MOLECULAR DIVERSITY (2015)
The history and future of targeting cyclin-dependent kinases in cancer therapy
Uzma Asghar et al.
NATURE REVIEWS DRUG DISCOVERY (2015)
Cytotoxicity of a naturally occurring furoquinoline alkaloid and four acridone alkaloids towards multi-factorial drug-resistant cancer cells
Victor Kuete et al.
PHYTOMEDICINE (2015)
Investigation of cytotoxic effects of various furanoacridones isolated from Ruta graveolens
Z Schelz et al.
PLANTA MEDICA (2015)
Synthesis and evaluation of the antitumor activity of polyhalo acridone derivatives
Chao Huang et al.
RSC ADVANCES (2015)
A POCl3-mediated synthesis of substituted fused azoacridones derivatives
Xi Li et al.
RSC ADVANCES (2015)
The Role of Multidrug Resistance Efflux Pumps in Cancer: Revisiting a JNCI Publication Exploring Expression of the MDR1 (P-glycoprotein) Gene
Michael M. Gottesman et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)
Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport-an Update
Qingcheng Mao et al.
AAPS JOURNAL (2015)
Targeting Multidrug Resistance Protein 1 (MRP1, ABCC1): Past, Present, and Future
Susan P. C. Cole
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 54 (2014)
Design and Synthesis of Quinazolinone Tagged Acridones as Cytotoxic Agents and Their Effects on EGFR Tyrosine Kinase
Yarlagadda Rajesh Babu et al.
ARCHIV DER PHARMAZIE (2014)
Supercoiling in DNA and chromatin
Nick Gilbert et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2014)
Synthesis, cytotoxic study and docking based multidrug resistance modulator potential analysis of 2-(9-oxoacridin-10(9H)-yl)-N-phenyl acetamides
Rajesh Kumar et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
Acridone Alkaloids from Glycosmis chlorosperma as DYRK1A Inhibitors
Mehdi A. Beniddir et al.
JOURNAL OF NATURAL PRODUCTS (2014)
Cyclin-Dependent Kinase Inhibitors as Marketed Anticancer Drugs: Where Are We Now? A Short Survey
Gaele Mariaule et al.
MOLECULES (2014)
Length-dependent processing of telomeres in the absence of telomerase
Emilie Fallet et al.
NUCLEIC ACIDS RESEARCH (2014)
Protein kinase C and cancer: what we know and what we do not
R. Garg et al.
ONCOGENE (2014)
Acridone alkaloids with cytotoxic and antimalarial activities from Zanthoxylum simullans Hance
Chao Wang et al.
PHARMACOGNOSY MAGAZINE (2014)
New series of acridines and phenanthrolines: synthesis and characterization
Amel Souibgui et al.
TETRAHEDRON (2014)
New Insight into P-Glycoprotein as a Drug Target
Albert Breier et al.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2013)
Hybrid fluorescent conjugates of COX-2 inhibitors: Search for a COX-2 isozyme imaging cancer biomarker
Atul Bhardwaj et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
Different strategies to overcome multidrug resistance in cancer
Manju Saraswathy et al.
BIOTECHNOLOGY ADVANCES (2013)
Synthesis, antiproliferative activity and tubulin targeting effect of acridinone and dioxophenothiazine derivatives
Valerie Verones et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
Chemosensitizing acridones: In vitro calmodulin dependent cAMP phosphodiesterase inhibition, docking, pharmacophore modeling and 3D QSAR studies
V. V. S. Rajendra Prasad et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2013)
Phytochemistry and pharmacognosy of the genus Acronychia
Francesco Epifano et al.
PHYTOCHEMISTRY (2013)
Targeting cellular metabolism to improve cancer therapeutics
Y. Zhao et al.
CELL DEATH & DISEASE (2013)
Metabolic Transformation of Antitumor Acridinone C-1305 but Not C-1311 via Selective Cellular Expression of UGT1A10 Increases Cytotoxic Response: Implications for Clinical Use
Monika Pawlowska et al.
DRUG METABOLISM AND DISPOSITION (2013)
P-glycoprotein Inhibition for Optimal Drug Delivery
Md. Lutful Amin
DRUG TARGET INSIGHTS (2013)
Transporters and Drug-Drug Interactions: Important Determinants of Drug Disposition and Effects
Joerg Koenig et al.
PHARMACOLOGICAL REVIEWS (2013)
Inhibition of Junin virus RNA synthesis by an antiviral acridone derivative
Claudia S. Sepulveda et al.
ANTIVIRAL RESEARCH (2012)
Novel acridine-based agents with topoisomerase II inhibitor activity suppress mesothelioma cell proliferation and induce apoptosis
Ahmad Raza et al.
INVESTIGATIONAL NEW DRUGS (2012)
Synthesis and evaluation of 10-(3,5-dimethoxy)benzyl-9(10H)-acridone derivatives as selective telomeric G-quadruplex DNA ligands
Chunmei Gao et al.
TETRAHEDRON (2012)
Multidrug resistance associated proteins in multidrug resistance
Kamlesh Sodani et al.
CHINESE JOURNAL OF CANCER (2012)
Role of Human UDP-Glucuronosyltransferases in the Biotransformation of the Triazoloacridinone and Imidazoacridinone Antitumor Agents C-1305 and C-1311: Highly Selective Substrates for UGT1A10
Barbara Fedejko-Kap et al.
DRUG METABOLISM AND DISPOSITION (2012)
Design, Synthesis and Evaluation of Substituted N-(3-Arylpropyl)-9,1 0-dihydro-9-oxoacridine-4-carboxamides as Potent MDR Reversal Agents in Cancer
V. S. Velingkar et al.
CHINESE JOURNAL OF CHEMISTRY (2011)
The acridone derivative MBLI-87 sensitizes breast cancer resistance protein-expressing xenografts to irinotecan
O. Arnaud et al.
EUROPEAN JOURNAL OF CANCER (2011)
Cytotoxicity studies of some novel fluoro acridone derivatives against sensitive and resistant cancer cell lines and their mechanistic studies
V. V. S. Rajendra Prasad et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2011)
Microwave-Assisted Synthesis and Evaluation of Substituted Aryl Propyl Acridone-4-Carboxamides as Potential Chemosensitizing Agents for Cancer
Vinaykumar S. Velingkar et al.
Letters in Drug Design & Discovery (2011)
Natural and synthetic acridines/acridones as antitumor agents: their biological activities and methods of synthesis
Grzegorz Cholewinski et al.
PHARMACOLOGICAL REPORTS (2011)
Flavin monooxygenases, FMO1 and FMO3, not cytochrome P450 isoenzymes, contribute to metabolism of anti-tumour triazoloacridinone, C-1305, in liver microsomes and HepG2 cells
Barbara Fedejko-Kap et al.
XENOBIOTICA (2011)
Triazoloacridin-6-ones as novel inhibitors of the quinone oxidoreductases NQO1 and NQO2
Karen A. Nolan et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Targeting efflux pumps-In vitro investigations with acridone derivatives and identification of a lead molecule for MDR modulation
Palwinder Singh et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Novel synthetic 2-amino-10-(3,5-dimethoxy)benzyl-9(10H)-acridinone derivatives as potent DNA-binding antiproliferative agents
Chunmei Gao et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
DNA Topoisomerase II Enzymes as Molecular Targets for Cancer Chemotherapy
K. Chikamori et al.
CURRENT CANCER DRUG TARGETS (2010)
The mechanism of the modified Ullmann reaction
Elena Sperotto et al.
DALTON TRANSACTIONS (2010)
Evaluation of the safety of C-1311 (SYMADEX) administered in a phase 1 dose escalation trial as a weekly infusion for 3 consecutive weeks in patients with advanced solid tumours
N. Isambert et al.
EUROPEAN JOURNAL OF CANCER (2010)
Synthesis, chemical characterization of novel 1,3-dimethyl acridones as cytotoxic agents, and their DNA-binding studies
N. K. Sathish et al.
MEDICINAL CHEMISTRY RESEARCH (2010)
Synthesis and pharmacological evaluation of 9(10H)-acridone bearing 1,3,4-oxadiazole derivatives as antimicrobial agents
Jumat Salimon et al.
ARABIAN JOURNAL OF CHEMISTRY (2010)
Acronycine Derivatives: A Promising Series of Anti-Cancer Agents
Q. C. Nguyen et al.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2009)
Synthesis of 2-Fluoro N10-Substituted Acridones and Their Cytotoxicity Studies in Sensitive and Resistant Cancer Cell Lines and Their DNA Intercalation Studies
Yergeri C. Mayur et al.
ARCHIV DER PHARMAZIE (2009)
Search for MDR modulators: Design, syntheses and evaluations of N-substituted acridones for interactions with p-glycoprotein and Mg2+
Palwinder Singh et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Synthesis of N-4-butylamine acridone and its use as fluorescent probe for ctDNA
Bin Qiu et al.
BIOSENSORS & BIOELECTRONICS (2009)
Telomeres and Telomerase: From Discovery to Clinical Trials
David R. Corey
CHEMISTRY & BIOLOGY (2009)
Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity
Thomas D. Pfister et al.
MOLECULAR CANCER THERAPEUTICS (2009)
Discovery of dual function acridones as a new antimalarial chemotype
Jane X. Kelly et al.
NATURE (2009)
Synthesis and potent antileukemic activities of 10-benzyl-9(10H)-acridinones
Chunmei Gao et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Chloro acridone derivatives as cytotoxic agents active on multidrug-resistant cell lines and their duplex DNA complex studies by electrospray ionization mass spectrometry
V. V. S. Rajendra Prasad et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2008)
Structure-activity relationships in the acronycine and benzo[b]acronycine series: Role of the pyran ring
Quyen Do et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2008)
Synthesis of 2-methyl N10-substituted acridones as selective inhibitors of multidrug resistance (MDR) associated protein in cancer cells
Y. C. Mayur et al.
MEDICINAL CHEMISTRY (2008)
Potential anti-allergic acridone alkaloids from the roots of Atalantia monophylla
Arnon Chukaew et al.
PHYTOCHEMISTRY (2008)
Flavin-containing monooxygenases: mutations, disease and drug response
Ian R. Phillips et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2008)
Optimization of naphthalimide-imidazoacridone with potent antitumor activity leading to clinical candidate (HKH40A, RTA 502)
Humcha K. Hariprakasha et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Protein kinases as targets for cancer treatment
Georgios Giamas et al.
PHARMACOGENOMICS (2007)
Synthesis and chemical characterization of N10-substituted acridones as reversers of multidrug resistance in cancer cells
Y. C. Mayur et al.
LETTERS IN DRUG DESIGN & DISCOVERY (2007)
Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents
Cristina Martins et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Acridone derivatives: Design, synthesis, and inhibition of breast cancer resistance protein ABCG2
Ahcene Boumendjel et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Modulation of P-glycoprotein activity by acridones and coumarins from Citrus sinensis
C. Bayet et al.
PHYTOTHERAPY RESEARCH (2007)
Investigation of cytotoxic activity on human cancer cell lines of arborinine and furanoacridones isolated from Ruta graveolens
Borbala Rethy et al.
PLANTA MEDICA (2007)
Acridine and acridone derivatives, anticancer properties and synthetic methods: Where are we now?
Philippe Belmont et al.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2007)
Multidrug resistance, in small cell lung cancer: Expression of P-glycoprotein, multidrug resistance protein 1 and lung resistance protein in chemo-naive patients and in relapsed disease
Nadja Triller et al.
LUNG CANCER (2006)
Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
Roger G. Deeley et al.
PHYSIOLOGICAL REVIEWS (2006)
Synthesis and anti-BVDV activity of acridones as new potential antiviral agents
O Tabarrini et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Substrate recognition and transport by multidrug resistance protein 1 (ABCC1)
RG Deeley et al.
FEBS LETTERS (2006)
Role of protein kinase B in breast cancer
E. M. Sale et al.
BREAST CANCER RESEARCH (2006)
Some distinctions between flavin-containing and cytochrome P450 monooxygenases
JR Cashman
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Cytotoxic acridone alkaloids from the stem bark of Citrus maxima
WY Teng et al.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY (2005)
Algicidal and antifungal compounds from the roots of Ruta graveolens and synthesis of their analogs
KA Meepagala et al.
PHYTOCHEMISTRY (2005)
The role of the multidrug resistance-associated protein 1 gene in neuroblastoma biology and clinical outcome
M Pajic et al.
CANCER LETTERS (2005)
Shelterin: the protein complex that shapes and safeguards human telomeres
T de Lange
GENES & DEVELOPMENT (2005)
Human DNA topoisomerase I: relaxation, roles, and damage control
JB Leppard et al.
CHROMOSOMA (2005)
Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism
SK Krueger et al.
PHARMACOLOGY & THERAPEUTICS (2005)
Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cells
M Hyzy et al.
BIOCHEMICAL PHARMACOLOGY (2005)
The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function
AM Burger et al.
CANCER RESEARCH (2005)
Synthesis, biological evaluation, and molecular modeling of novel thioacridone derivatives related to the anticancer alkaloid acronycine
JP Dheyongera et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
PI3K/Akt/mTOR pathway as a target for cancer therapy
D Morgensztern et al.
ANTI-CANCER DRUGS (2005)
Cytochrome c release induces apoptosis of nasopharyngeal carcinoma (NPC) by antitumor glyfoline
TL Su et al.
PLANTA MEDICA (2005)
Antileishmanial and antifungal acridone derivatives from the roots of Thamnosma rhodesica
KM Ahua et al.
PHYTOCHEMISTRY (2004)
Anti-calmodulin acridone derivatives modulate vinblastine resistance in multidrug resistant (MDR) cancer cells
R Hegde et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2004)
Synthesis and evaluation of novel pyrimido-acridone, -phenoxadine, and -carbazole as topoisomerase II inhibitors
J Kamata et al.
CHEMICAL & PHARMACEUTICAL BULLETIN (2004)
Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents
A Kamal et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Preclinical pharmacokinetic properties of the P-glycoprotein inhibitor GF120918A (HCl salt of GF120918, 9,10-dihydro-5-methoxy-9-oxo-N-[4-[ 2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]phenyl]-4-acridine-carboxamide) in the mouse, rat, dog, and monkey
KW Ward et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Benzo[b]acronycine derivatives:: a novel class of antitumor agents
S Michel et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2004)
Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding
RJ Harrison et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins
D Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout cells to antitumor triazoloacridone C-1305 is associated with permanent G2 cell cycle arrest
J Wesierska-Gadek et al.
CANCER RESEARCH (2004)
Tuning of intercalation and electron-transfer processes between DNA and acridinium derivatives through steric effects
J Joseph et al.
BIOCONJUGATE CHEMISTRY (2004)
Anthracyclines: Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
G Minotti et al.
PHARMACOLOGICAL REVIEWS (2004)
Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in colon cancer cells
A Deguchi et al.
CANCER RESEARCH (2004)
The antitumor triazoloacridone C-1305 is a topoisomerase II poison with unusual properties
K Lemke et al.
MOLECULAR PHARMACOLOGY (2004)
Mechanisms of action of DNA intercalating acridine-based drugs: How important are contributions from electron transfer and oxidative stress?
BC Baguley et al.
CURRENT MEDICINAL CHEMISTRY (2003)
Trisubstituted acridine derivatives as potent and selective telomerase inhibitors
RJ Harrison et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Imaging of dihydrofolate reductase fusion gene expression in xenografts of human liver metastases of colorectal cancer in living rats
P Mayer-Kuckuk et al.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2003)
Design, synthesis, and biological properties of new bis(acridine-4-carboxamides) as anticancer agents
I Antonini et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Protein kinase inhibitors as a therapeutic modality
A Levitzki
ACCOUNTS OF CHEMICAL RESEARCH (2003)
Cancer chemopreventive activity of acridone alkaloids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis
M Itoigawa et al.
CANCER LETTERS (2003)
3-Amino thioacridone, a selective cyclin-dependent kinase 4 inhibitor, attenuates kainic acid-induced apoptosis in neurons
E Verdaguer et al.
NEUROSCIENCE (2003)
Dual topoisomerase I/II inhibitors in cancer therapy
WA Denny et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2003)
Quinoline, quinazoline and acridone alkaloids
JP Michael
NATURAL PRODUCT REPORTS (2002)
Synthesis and antiinflammatory evaluation of 9-anilinoacridine and 9-phenoxyacridine derivatives
YL Chen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Alkylation of guanine in DNA by S23906-1, a novel potent antitumor compound derived from the plant alkaloid acronycine
MH David-Cordonnier et al.
BIOCHEMISTRY (2002)
Synthesis and chemical characterization of 2-methoxy-N10-substituted acridones needed to reverse vinblastine resistance in multidrug resistant (MDR) cancer cells
G Krishnegowda et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2002)
Cellular roles of DNA topoisomerases: A molecular perspective
JC Wang
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
Topoisomerase II-α expression in different cell cycle phases in fresh human breast carcinomas
K Villman et al.
MODERN PATHOLOGY (2002)
The protein kinase B/Akt signalling pathway in human malignancy
KM Nicholson et al.
CELLULAR SIGNALLING (2002)
Inhibition of protein kinase B/Akt: implications for cancer therapy
MM Hill et al.
PHARMACOLOGY & THERAPEUTICS (2002)
Drugs as P-glycoprotein substrates, inhibitors, and inducers
RB Kim
DRUG METABOLISM REVIEWS (2002)
Induction of cyclin E and inhibition of DNA synthesis by the novel acronycine derivative S23906-1 precede the irreversible arrest of tumor cells in S phase leading to apoptosis
S Léonce et al.
MOLECULAR PHARMACOLOGY (2001)
被撤回的出版物: Pro-survival function of Akt/protein kinase B in prostate cancer cells - Relationship with trail resistance (Retracted Article. See vol 277, pg 30408, 2002)
H Thakkar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors
M Read et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Protein kinase inhibitors: emerging pharmacophores 1997-2000
J Dumas
EXPERT OPINION ON THERAPEUTIC PATENTS (2001)
Topoisomerase I poisons and suppressors as anticancer drugs
C Bailly
CURRENT MEDICINAL CHEMISTRY (2000)