Long-term outcomes of osilodrostat in Cushing's disease: LINC 3 study extension

ObjectiveTo investigate the long-term efficacy and tolerability of osilodrostat, a potent oral 11 beta-hydroxylase inhibitor, for treating Cushing's disease (CD). Design/methodsA total of 137 adults with CD and mean 24-h urinary free cortisol (mUFC) > 1.5 x upper limit of normal (ULN) received osilodrostat (starting dose 2 mg bid; maximum 30 mg bid) during the prospective, Phase III, 48-week LINC 3 (NCT02180217) core study. Patients benefiting from osilodrostat at week 48 could enter the optional extension (ending when all patients had received >= 72 weeks of treatment or discontinued). Efficacy and safety were assessed for all enrolled patients from the core study baseline. ResultsMedian osilodrostat exposure from the core study baseline to study end was 130 weeks (range 1-245) and median average dose was 7.4 mg/day (range 0.8-46.6). The reduction in mean mUFC achieved during the core was maintained during the extension and remained <= ULN. Of 106 patients, 86 (81%) patients who entered the extension had mUFC <= ULN at week 72. Improvements in cardiovascular/metabolic-related parameters, physical manifestations of hypercortisolism (fat pads, central obesity, rubor, striae, and hirsutism in females), and quality of life in the core study were also maintained or improved further during the extension. No new safety signals were reported; 15/137 (10.9%) and 12/106 (11.3%) patients discontinued for adverse events during the core and extension, respectively. Mean testosterone in females decreased towards baseline levels during the extension. ConclusionsData from this large, multicentre trial show that long-term treatment with osilodrostat sustains cortisol normalisation alongside clinical benefits in most patients with CD and is well tolerated.

Automated summary

This study demonstrates that long-term treatment with osilodrostat is effective in maintaining cortisol normalization, improving symptoms, and is well tolerated in patients with Cushing's disease.