Metagenomic next-generation sequencing restores the diagnosis of a rare infectious complication of B cell depletion

A 45-year-old female patient receiving rituximab for B cell non-Hodgkin follicular lymphoma presented unexplained recurrent fever, abdominal discomfort, and pollakiuria. We performed shotgun metagenomic sequencing from peri-kidney collection that identified a co-infection with Mycoplasma hominis and Ureaplasma urealyticum. The patient recovered with sequelae after appropriate antibiotic treatment was given.

Automated summary

This is a case report of a 45-year-old female patient receiving rituximab for B cell non-Hodgkin follicular lymphoma, who presented with unexplained recurrent fever, abdominal discomfort, and pollakiuria. Shotgun metagenomic sequencing from peri-kidney collection identified a co-infection with Mycoplasma hominis and Ureaplasma urealyticum. The patient recovered with sequelae after appropriate antibiotic treatment was given.