期刊
EUROPEAN JOURNAL OF CANCER
卷 174, 期 -, 页码 68-77出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2022.07.005
关键词
Lenvatinib; Toripalimab; Hepatic arterial infusion chemotherapy; High-risk advanced hepatocellular carcinoma; Predictive biomarkers
类别
资金
- National Natural Sci- ence Foundation of China [82102985, 82072610]
- Development Planned Project in Key Areas of Guangdong Province [2019B110233002]
- China Postdoctoral Science Foundation [2021TQ0383]
In this study, we investigated the efficacy, safety, and predictive biomarkers of lenvatinib, toripalimab, and FOLFOX-HAIC combination therapy as a first-line treatment for high-risk advanced hepatocellular carcinoma (HCC). The results showed encouraging antitumour activity with a progression-free survival rate of 80.6% at six months. Adverse events were common, and the levels of CCL28 and BTC may predict the efficacy of the combination therapy.
Introduction: The combination of lenvatinib, toripalimab and hepatic arterial infu-sion chemotherapy (HAIC) with oxaliplatin, leucovorin, and 5-fluorouracil (FOLFOX) sug-gested encouraging antitumour activity in our retrospective study. We hereby prospectively establish the efficacy, safety and predictive biomarkers of the combination therapy as a first-line treatment in patients with high-risk advanced hepatocellular carcinoma (HCC). Materials and methods: This phase II, single-centre, single-arm trial enrolled advanced HCC participants with high-risk. Of 51 screened participants, 36 received lenvatinib, toripalimab plus FOLFOX-HAIC. Participants received 21-day treatment cycles of lenvatinib, toripali-mab, and FOLFOX-HAIC. The primary end-point was the progression-free survival (PFS) rate per RECIST at six months.Results: Thirty-six participants (86.1% with high-risk features) were enrolled in our study. The primary end-point was met with a PFS rate of 80.6% (95% CI, 64.0%-91.8%) at six months. The median PFS was 10.4 months (95% CI, 5.8-15.0), and the median OS was not reached at the prespecified final analysis and was 17.9 months (95% CI, 14.5-21.3) after follow-up was extended. The ORR per RECIST was 63.9%, and per mRECIST was 66.7%. The median duration of response was 14.4 months (95% CI, 8.9-19.9). The most common adverse events were thrombocytopenia, elevated aspartate aminotransferase, and hypertension, and no treatment-related death was reported. Participants with low levels of both CCL28 and BTC had unsatisfactory prognosis.Conclusions: Lenvatinib, toripalimab and FOLFOX-HAIC showed safe and encouraging antitumour activity for advanced HCC with high-risk features. The levels of CCL28 and BTC might be the predictive biomarkers for the triple combination therapy.(c) 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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