Lipoprotein(a) and aortic valve stenosis: work in progress

Schematic illustration of the observational and genetic evidence that LDL-cholesterol (LDL-C) and lipoprotein(a) [Lp(a)] might be involved in the pathogenesis of aortic valve stenosis and/or aortic valve calcification. Recent trials with statins had no effect on the aortic valve outcomes. Questions concerning trials to be planned with Lp(a)-lowering drugs are listed. OxPL, oxidized phospholipids.

Automated summary

This article schematically illustrates the observational and genetic evidence that suggests LDL-cholesterol and lipoprotein(a) may be involved in the pathogenesis of aortic valve stenosis and/or aortic valve calcification. Recent trials with statins had no effect on the outcomes of the aortic valve. The questions about planned trials with Lp(a)-lowering drugs are listed.