期刊
CANCER SCIENCE
卷 106, 期 12, 页码 1669-1677出版社
WILEY
DOI: 10.1111/cas.12818
关键词
Exosomes; metastasis; microenvironment nasopharyngeal carcinoma; MMP13
类别
资金
- Chinese National Natural Science Foundation [81172841, 81202368, 81471603]
- Natural Science Foundation of Jiangsu Province [SBK2015022581]
- China Postdoctoral Science Foundation [2013M541708]
- Project of 333 Natural Science Foundation of Jiangsu Grant [BRA2013286]
- Top Six Types of Talents Financial Assistance of Jiangsu Province Grant
- Project of Jiangsu Provincial Health Department [Z201005]
Nasopharyngeal cancer (NPC) is an endemic type of head and neck cancer with a high rate of cervical lymph node metastasis. Metastasis is the major cause of death in NPC patients. Increasing evidence indicates that exosomes play a pivotal role in promoting cancer metastasis by enhancing angiogenesis and ECM degradation. Matrix metalloproteinase 13 is an important kind of matrix proteinase that is often overexpressed in various tumors and increases the risk of metastasis. However, little is known about the potential role of MMP13-containing exosomes in NPC. In this study, we found that MMP13 was overexpressed in NPC cells and exosomes purified from conditioned medium (CM) as well as NPC patients' plasma. Transwell analysis revealed that MMP13-containing exosomes facilitated the metastasis of NPC cells. Furthermore, siRNA inhibited the effect of MMP13-containing exosomes on tumor cells metastasis as well as angiogenesis. The current findings provided novel insight into the vital role of MMP13-containing exosomes in NPC progression which might offer unique insights for potential therapeutic strategies for NPC progressions.
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