期刊
ENVIRONMENTAL RESEARCH
卷 212, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2022.113194
关键词
Phthalates; Human; Urine; Exposure; Cosmetics; Personal care products
Phthalates are widely used chemicals in everyday consumer products and their exposure through the use of personal care products can lead to various health effects. Time of sampling, frequency of use, race, and age are critical factors that influence phthalate concentrations. Specific personal care products, such as perfumes and fragrance-containing products, show significant associations with phthalate levels.
Phthalates are a large group of chemicals used in many everyday consumer products such as food packaging, household cleaners, cosmetics, fragrances and personal care products (PCPs). A number of diseases such as obesity, hypertension, as well as reproductive system effects and endocrine disorders have been linked to phthalate exposure through the use of PCPs, due to their frequent use and high phthalate content. In this study we review available literature on phthalates and their metabolites in urine and report the various determinants of exposure through the use of PCPs in infants, toddlers, children and adults. The range of creatinine-adjusted concentrations for each phthalate was 1.5-14956.1 mu g/g for MEP, 0.4-94.5 mu g/g for MEHP, 0.39-425.9 mu g/g for MEHHP, 0.5-481.3 mu g/g for MEOHP, 0.1-755.1 mu g/g for MBzP, and 0.3-401.4 mu g/g for MiBP. Time of sampling, frequency of use, race and age are critical factors that influence phthalate concentrations. Using PCPs 48 h before urine collection, using a combination of PCPs (i.e., particularly leave-on versus rinse-off products), being younger (i.e., children compared to their mothers), and being a woman of colour (i.e., Mexican-American and black versus white) leads to higher phthalate levels in urine. The most striking association between any phthalate and PCPs was observed between MEP and perfumes or fragrance-containing products such as shampoos, body lotions and hair products. Future studies should focus on different types and brands of PCPs (i.e., branded versus generic), explore possible ethnic/racial differences and the applicability of non-invasive matrices such as nails and hair for phthalate biomonitoring, as well as intervention studies that explore behavioural changes.
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