4.8 Article

Environmental behavior of the chiral fungicide epoxiconazole in earthworm-soil system: Enantioselective enrichment, degradation kinetics, chiral metabolite identification, and biotransformation mechanism

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Environmental Sciences

Mechanistic insights into primary biotransformation of diethyl phthalate in earthworm and significant SOD inhibitory effect of esterolytic products

Xiuli Fan et al.

Summary: The study illustrated the biotransformation of DEP into MEP and PA in earthworms, driven by endogenous carboxylesterase. MEP showed higher inhibition of SOD activity than DEP, with PA having even stronger inhibition effect. The direct binding interaction with SOD, causing conformational changes, was believed to underlie inhibition efficiency of SOD activity.

CHEMOSPHERE (2022)

Article Environmental Sciences

Azole fungicides: (Bio)degradation, transformation products and toxicity elucidation

Amanda Pacholak et al.

Summary: The study shows that the increasing consumption of azole antifungal agents leads to their uncontrolled release into the environment, and biological and chemical degradation methods can effectively remove these agents. Among the azole fungicides examined, climbazole was the most susceptible to biological removal, while a combination of UV treatment and the Fenton reaction offered the best results for removal.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

Article Chemistry, Medicinal

Methysticin Acts as a Mechanism-Based Inactivator of Cytochrome P450 2C9

Qiuying Zhang et al.

Summary: This study revealed that methysticin is a mechanism-based inactivator of CYP2C9 and CYP1A2, 2C9, and 3A4 are the major enzymes responsible for the bioactivation of methysticin.

CHEMICAL RESEARCH IN TOXICOLOGY (2022)

Article Environmental Sciences

Conazole fungicides epoxiconazole and tebuconazole in biochar amended soils: Degradation and bioaccumulation in earthworms

Nikola Boskovic et al.

Summary: Our study investigated the degradation and bioaccumulation of conazole fungicides in soils amended with different biochars, finding that the presence of biochars promoted the degradation of fungicides with a clear effect of dose and soil type. However, the bioaccumulation factors were higher in low-sorbing soil variants and decreased with increasing biochar dose, indicating a complex interaction between soil, biochar, and fungicide fate.

CHEMOSPHERE (2021)

Article Engineering, Environmental

Biotransformation of Current-Use Progestin Dienogest and Drospirenone in Laboratory-Scale Activated Sludge Systems Forms High-Yield Products with Altered Endocrine Activity

Haoqi Nina Zhao et al.

Summary: Dienogest and drospirenone, two fourth-generation synthetic progestins widely used in oral contraceptives, undergo biotransformation during biological wastewater treatment to form various transformation products with potential environmental implications.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2021)

Article Environmental Sciences

Enantioselective bioaccumulation and detoxification mechanisms of earthworms (Eisenia fetida) exposed to mandipropamid

Kuan Fang et al.

Summary: This study investigated the enantioselective bioaccumulation and detoxification mechanisms of mandipropamid isomers in earthworms. The results showed that detoxification systems play an essential role in the stress response to mandipropamid exposure, with earthworms being more sensitive to S-(+)-mandipropamid than R-(-)-mandipropamid. Additionally, differentially expressed genes related to detoxification pathways were identified, providing insights for remediating chiral pollutants.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Review Environmental Sciences

Metabolism and detoxification of pesticides in plants

Jing Jing Zhang et al.

Summary: This review discusses the mechanistic insights into pesticide metabolic pathways and the development of improved plant genotypes for more effective breakdown of pesticides. It highlights the identification of major pesticide-metabolized enzymes and the roles of signal molecules in pesticide metabolism and detoxification. The emphasis is also placed on emerging research on epigenetic mechanisms for pesticide metabolism in plants.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Engineering, Environmental

Mechanistic Aspects Regarding the Ultraviolet Degradation of Polychlorinated Biphenyls in Different Media: Insights from Carbon and Chlorine Isotope Fractionation

Chenchen Huang et al.

Summary: This study investigated the carbon and chlorine isotope fractionation during ultraviolet-photolysis of PCBs in different photochemical systems, revealing differences in degradation processes. Nondechlorinated pathways and magnetic isotope effects were suggested in MeOH/H2O for PCB138. Significant negative correlations were found between C-AKIE and relative disappearance quantum yields of ortho-dechlorinated substrates in Hex and MeOH/H2O.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2021)

Article Engineering, Environmental

Multistage Defense System Activated by Tetrachlorobiphenyl and its Hydroxylated and Methoxylated Derivatives in Oryza sativa

Na Liu et al.

Summary: In response to organic pollutants, rice plants activate defense systems including cytochrome P450s, glutathione S-transferases, and phenylpropanoid biosynthesis to reallocate metabolites and improve adaptability. This novel strategy enhances crop outputs and quality in environments impacted by organic contaminants.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2021)

Article Engineering, Environmental

Effects of antimony contamination on bioaccumulation and gut bacterial community of earthworm Eisenia fetida

Bocong Huang et al.

Summary: The study revealed that antimony contamination can lead to earthworm mortality and accumulation in the gut and tissues. There are significant differences in diversity and stability between the bacterial communities in the earthworm gut and soil.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Article Agriculture, Multidisciplinary

New Biotransformation Mode of Zearalenone Identified in Bacillus subtilis Y816 Revealing a Novel ZEN Conjugate

Shi Bin Yang et al.

Summary: The Bacillus subtilis Y816 strain was found to efficiently transform ZEN into ZEN-14-phosphate and E2-3-phosphate, resulting in reduced estrogenic toxicity. A zearalenone phosphotransferase (ZPH) was identified as the enzyme responsible for the phosphorylation of ZEN. This discovery opens new perspectives on the biotransformation of ZEN in Bacillus strains.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Article Biochemical Research Methods

Development of derivatization reagents bearing chiral 4-imidazolidinone for distinguishing primary amines from other amino acids and application to the liquid chromatography-tandem mass spectrometric analysis of miso

Tatsuya Sakamoto et al.

Summary: Three novel derivatization reagents containing chiral 4-imidazolidinone were designed and synthesized for LC-MS/MS analysis, showing good performance in enantioseparation of amino acids and detection sensitivity. The optimal reagent (CIMa-OSu) was able to simultaneously determine the content of multiple amino acids in samples.

JOURNAL OF CHROMATOGRAPHY A (2021)

Article Engineering, Environmental

Enantiomeric profiling of mefentrifluconazole in watermelon across China: Enantiochemistry, environmental fate, storage stability, and comparative dietary risk assessment

Ziqi Liu et al.

Summary: The study focused on elucidating the enantiomeric chemistry and enantioselective fate of the novel chiral triazole fungicide mefentrifluconazole, with a particular emphasis on its persistence and potential risks to urban children. Probabilistic models were recommended for dietary risk assessment, with both acute and chronic risks deemed acceptable for the associated population.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Article Engineering, Environmental

Degradation of difenoconazole in water and soil: Kinetics, degradation pathways, transformation products identification and ecotoxicity assessment

Yanli Man et al.

Summary: The laboratory experiments revealed that difenoconazole undergoes oxidation, dechlorination, and hydroxylation reactions in the environment, leading to the formation of various transformation products. Four novel transformation products showed lower acute toxicity compared to difenoconazole, but were predicted to be chronically very toxic to fish, posing a potential threat to aquatic ecosystems.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Article Chemistry, Medicinal

Biotransformation Mechanism of Pesticides by Cytochrome P450: A DFT Study on Dieldrin

Lihong Chai et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2020)

Article Engineering, Environmental

Enantioselective bioactivity, toxicity, and degradation in different environmental mediums of chiral fungicide epoxiconazole

Amir E. Kaziem et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

Article Green & Sustainable Science & Technology

Method for Determining CYP2C9 Activity in Earthworms and its Responses to Benzo[a] pyrene or Pyrene in Soil

Xiaoxia Yang et al.

CLEAN-SOIL AIR WATER (2019)

Article Environmental Sciences

Effects of triazole fungicides on androgenic disruption and CYP3A4 enzyme activity

Xuan Lv et al.

ENVIRONMENTAL POLLUTION (2017)

Article Engineering, Environmental

Microsomal Metabolism of Prochiral Polychlorinated Biphenyls Results in the Enantioselective Formation of Chiral Metabolites

Eric Uwimana et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2017)

Article Engineering, Environmental

Uptake, Translocation, and Biotransformation of Organophosphorus Esters in Wheat (Triticum aestivum L.)

Weining Wan et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2017)

Article Engineering, Environmental

How Biotransformation Influences Toxicokinetics of Azole Fungicides in the Aquatic Invertebrate Gammarus pulex

Andrea Rosch et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2016)

Article Engineering, Environmental

Tissue-Specific Accumulation, Depuration, and Transformation of Triphenyl Phosphate (TPHP) in Adult Zebrafish (Danio rerio)

Guowei Wang et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2016)

Article Environmental Sciences

Stereoselectivity in bioaccumulation and excretion of epoxiconazole by mealworm beetle (Tenebrio molitor) larvae

Xiaotian Lv et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2014)

Editorial Material Engineering, Environmental

Identifying Small Molecules via High Resolution Mass Spectrometry: Communicating Confidence

Emma L. Schymanski et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2014)

Article Agriculture, Multidisciplinary

Enantioselective Determination of Triazole Fungicide Epoxiconazole Bioaccumulation in Tubifex Based on HPLC-MS/MS

Chunxiao Liu et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2014)

Article Engineering, Environmental

Chlordane and Heptachlor Are Metabolized Enantioselectively by Rat Liver Microsomes

Izabela Kania-Korwel et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2013)

Article Engineering, Environmental

Metabolites of 2,4,4′-Tribrominated Diphenyl Ether (BDE-28) in Pumpkin after In Vivo and In Vitro Exposure

Miao Yu et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2013)

Article Multidisciplinary Sciences

Structural Basis for Effector Control and Redox Partner Recognition in Cytochrome P450

Sarvind Tripathi et al.

SCIENCE (2013)

Article Oncology

PRENATAL EPOXICONAZOLE EXPOSURE EFFECTS ON RAT POSTNATAL DEVELOPMENT

Vera L. S. S. de Castro et al.

BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY (2012)

Article Engineering, Environmental

Epoxiconazole degradation from artificial wetland and forest buffer substrates under flooded conditions

Elodie Passeport et al.

CHEMICAL ENGINEERING JOURNAL (2011)

Review Chemistry, Multidisciplinary

Enantiocomplementary Enzymes: Classification, Molecular Basis for Their Enantiopreference, and Prospects for Mirror-Image Biotransformations

Paul F. Mugford et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)

Article Engineering, Environmental

Influence of pH on the stereoselective degradation of the fungicides epoxiconazole and cyproconazole in soils

Ignaz J. Buerge et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2006)

Review Biotechnology & Applied Microbiology

Chirality of pollutants -: effects on metabolism and fate

TA Müller et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2004)