期刊
EMBO REPORTS
卷 23, 期 10, 页码 -出版社
WILEY
DOI: 10.15252/embr.202255664
关键词
commensals; immune; metabolites; microbiome; postbiotic
资金
- Deutsche Forschungsgemeinschaft [SP 1902/1-1]
- Leona M. and Harry B. Helmsley Charitable Trust
- Adelis Foundation
- Ben B. and Joyce E. Eisenberg Foundation
- Estate of Bernard Bishin for the WIS-Clalit Program
- Jeanne and Joseph Nissim Center for Life Sciences Research
- Miel de Botton
- Vera Rosenberg Schwartz Research Fellow Chair
- Swiss Society Institute for Cancer Prevention Research
- Belle S. and Irving E. Meller Center for the Biology of Aging
- Sagol Institute for Longevity Research
- Sagol Weizmann-MIT Bridge Program
- Norman E Alexander Family M Foundation Coronavirus Research Fund
- Mike and Valeria Rosenbloom Foundation
- Daniel Morris Trust
- Isidore and Penny Myers Foundation
- Vainboim Family
- European Research Council
- Israel Science Foundation
- Israel Ministry of Science and Technology
- Israel Ministry of Health
- German-Israeli Helmholtz International Research School: Cancer-TRAX [HIRS-0003]
- Helmholtz Association's Initiative and Networking Fund
- Minerva Foundation
- Garvan Institute
- European Crohn's and Colitis Organization
- Deutsch-Israelische Projektkooperation
- IDSA Foundation
- WIS-MIT grant
- Emulate
- Charlie Teo Foundation
- Mark Foundation for Cancer Research
- Welcome Trust
- Projekt DEAL
Microbiomes form distinct ecosystems within their hosts and can impact the host's physiology through metabolite production, which may have therapeutic applications.
Commensal microbes form distinct ecosystems within their mammalian hosts, collectively termed microbiomes. These indigenous microbial communities broadly expand the genomic and functional repertoire of their host and contribute to the formation of a meta-organism. Importantly, microbiomes exert numerous biochemical reactions synthesizing or modifying multiple bioactive small molecules termed metabolites, which impact their host's physiology in a variety of contexts. Identifying and understanding molecular mechanisms of metabolite-host interactions, and how their disrupted signaling can contribute to diseases, may enable their therapeutic application, a modality termed postbiotic therapy. In this review, we highlight key examples of effects of bioactive microbe-associated metabolites on local, systemic, and immune environments, and discuss how these may impact mammalian physiology and associated disorders. We outline the challenges and perspectives in understanding the potential activity and function of this plethora of microbially associated small molecules as well as possibilities to harness them toward the promotion of personalized precision therapeutic interventions.
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