4.8 Article

Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Neurosciences

Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons

Juliet Goldsmith et al.

Summary: This study reveals the importance of autophagy in maintaining neuronal health. By isolating autophagic vesicles and using proteomics, the researchers identified mitochondrial proteins as a major cargo engulfed in autophagosomes. They also found that nucleoid-associated proteins are enriched in autophagic engulfment of nucleoid-enriched mitochondrial fragments, and this process requires the mitochondrial fission machinery protein Drp1.

NEURON (2022)

Review Cell Biology

Autophagy and ALS: mechanistic insights and therapeutic implications

Jason P. Chua et al.

Summary: Protein homeostasis mechanisms are crucial for maintaining the health of neurons and other cells in the central nervous system, while autophagy plays a key role in preventing and combating pathogenic insults that may lead to neurodegenerative diseases. However, the specific mechanisms underlying the neuroprotective role of autophagy, neuronal resistance to autophagy induction, and the effects of autophagy-impairing mutations on neurons are not fully understood. Additionally, the contribution of non-cell autonomous effects of autophagy dysfunction to ALS pathogenesis remains incompletely defined.

AUTOPHAGY (2022)

Article Cell Biology

Autophagy coupled to translation is required for long-term memory

Kiran Pandey et al.

Summary: An increase in autophagy following learning is essential for long-term memory formation, but not necessary for the increase in protein synthesis. The upregulation of autophagy proteins is due to active translation of their mRNA rather than changes in total mRNA levels.

AUTOPHAGY (2021)

Review Biochemistry & Molecular Biology

Mechanisms of neuronal survival safeguarded by endocytosis and autophagy

Melina Overhoff et al.

Summary: Neurons rely on the autophagy and endocytosis pathways for cellular homeostasis and function, with defects in these pathways linked to the pathology of neurodegenerative diseases.

JOURNAL OF NEUROCHEMISTRY (2021)

Article Neurosciences

Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum

Marijn Kuijpers et al.

Summary: This study demonstrates that loss of neuronal autophagy leads to selective accumulation of tubular endoplasmic reticulum (ER) in axons, resulting in increased excitatory neurotransmission and compromised postnatal viability in vivo. The elevated excitatory neurotransmission is caused by increased calcium release from ER stores via ryanodine receptors accumulated in axons and at presynaptic sites. Neuronal autophagy controls axonal ER calcium stores to regulate neurotransmission in healthy neurons and in the brain.

NEURON (2021)

Article Cell Biology

Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity

You Wang et al.

Summary: The study showed that vezatin expression was increased in epileptic mice and in an in vitro seizure-like model. Knockdown of vezatin suppressed seizure activity and affected AMPAR-mediated neuronal synaptic transmission and the surface expression of GluA1. The findings suggest that vezatin-mediated regulation represents a novel target for epilepsy treatment.

CELL DEATH & DISEASE (2021)

Review Biochemistry & Molecular Biology

From structure to the dynamic regulation of a molecular switch: A journey over 3 decades

Susan S. Taylor et al.

Summary: The Protein Data Bank has played a crucial role in the signaling community for over 30 years, facilitating information sharing between academics and industry. Through the study of protein kinases, particularly cAMP-dependent protein kinase, researchers have made significant discoveries including the importance of crystal packing in biological processes and disease relevance. Integrating crystallography with other techniques is opening up new possibilities for understanding intrinsically disordered regions and dynamic biological processes.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Multidisciplinary Sciences

Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth

Zhiqiang Deng et al.

Summary: The study reveals that autophagy plays a critical role in protecting cells during energy crisis by regulating cell metabolism, specifically through the selective degradation of the PKA inhibitory subunit RI. This selective autophagy process activates PKA, promotes mitochondrial metabolism, and enhances cell survival under glucose deprivation conditions.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95

Benjamin Compans et al.

Summary: Long-term depression (LTD) of synaptic strength is associated with circuit remodeling, memory encoding, and erasure. P2XR- and NMDAR-dependent LTD are linked to distinct molecular modifications that lead to specific changes in synapse function.

NATURE COMMUNICATIONS (2021)

Review Neurosciences

Calcium Permeable-AMPA Receptors and Excitotoxicity in Neurological Disorders

Changyong Guo et al.

Summary: Excitotoxicity is a key mechanism of cell loss in various diseases of the central and peripheral nervous systems. In addition to the previously established pathways, CP-AMPAR-mediated excitotoxicity is identified in multiple disease models. Specific manipulation of CP-AMPARs may be a more effective strategy to delay pathological changes with fewer side effects compared to blocking NMDARs.

FRONTIERS IN NEURAL CIRCUITS (2021)

Article Cell Biology

Dynamic bi-directional phosphorylation events associated with the reciprocal regulation of synapses during homeostatic up- and down-scaling

Kristina Desch et al.

Summary: Protein phosphorylation plays a crucial role in cellular processes. Liquid chromatography-tandem mass spectrometry was used to analyze changes in phosphorylation in response to up- or down-scaling in cultured cortical neurons. Activity-sensitive phosphoproteins are mainly located at synapses and involved in cytoskeletal reorganization.

CELL REPORTS (2021)

Article Biochemical Research Methods

DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput

Vadim Demichev et al.

NATURE METHODS (2020)

Article Multidisciplinary Sciences

Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring

Ferdi Ridvan Kiral et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Generating high quality libraries for DIA MS with empirically corrected peptide predictions

Brian C. Searle et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Mitophagy regulates integrity of mitochondria at synapses and is critical for synaptic maintenance

Sinsuk Han et al.

EMBO REPORTS (2020)

Article Multidisciplinary Sciences

Autophagy controls the induction and developmental decline of NMDAR-LTD through endocytic recycling

Hongmei Shen et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner

Anuradha Bhukel et al.

NATURE COMMUNICATIONS (2019)

Review Neurosciences

Ketogenic Diet and Epilepsy: What We Know So Far

Isabella D'Andrea Meira et al.

FRONTIERS IN NEUROSCIENCE (2019)

Article Biochemical Research Methods

Prosit: proteome-wide prediction of peptide tandem mass spectra by deep learning

Siegfried Gessulat et al.

NATURE METHODS (2019)

Article Multidisciplinary Sciences

Wilm's tumor 1 promotes memory flexibility

Chiara Mariottini et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals

Maria Andres-Alonso et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Autophagy Is Required for Memory Formation and Reverses Age-Related Memory Decline

Melissa Glatigny et al.

CURRENT BIOLOGY (2019)

Article Neurosciences

Light-Activated ROS Production Induces Synaptic Autophagy

Sheila Hoffmann et al.

JOURNAL OF NEUROSCIENCE (2019)

Article Biochemical Research Methods

Single-pot, solid-phase-enhanced sample preparation for proteomics experiments

Christopher S. Hughes et al.

NATURE PROTOCOLS (2019)

Review Cell Biology

Mechanism and medical implications of mammalian autophagy

Ivan Dikic et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Correction Neurosciences

Bassoon Controls Presynaptic Autophagy through Atg5 (vol 93, pg 897, 2017)

Nathan D. Okerlund et al.

NEURON (2018)

Review Clinical Neurology

Selective autophagy as a potential therapeutic target for neurodegenerative disorders

Aurora Scrivo et al.

LANCET NEUROLOGY (2018)

Article Multidisciplinary Sciences

Instant Clue: A Software Suite for Interactive Data Visualization and Analysis

Hendrik Nolte et al.

SCIENTIFIC REPORTS (2018)

Review Clinical Neurology

Epilepsy in patients with autism: links, risks and treatment challenges

Frank M. C. Besag

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2018)

Article Biochemical Research Methods

Differential analysis of RNA-seq incorporating quantification uncertainty

Harold Pimentel et al.

NATURE METHODS (2017)

Article Multidisciplinary Sciences

Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease

Patrick Lueningschroer et al.

NATURE COMMUNICATIONS (2017)

Article Cell Biology

Modulation of Autophagy by BDNF Underlies Synaptic Plasticity

Vassiliki Nikoletopoulou et al.

CELL METABOLISM (2017)

Article Cell Biology

KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses

Andrea K. H. Stavoe et al.

DEVELOPMENTAL CELL (2016)

Article Neurosciences

Compartment-Specific Regulation of Autophagy in Primary Neurons

Sandra Maday et al.

JOURNAL OF NEUROSCIENCE (2016)

Article Biotechnology & Applied Microbiology

Near-optimal probabilistic RNA-seq quantification

Nicolas L. Bray et al.

NATURE BIOTECHNOLOGY (2016)

Article Biochemical Research Methods

The Perseus computational platform for comprehensive analysis of (prote)omics data

Stefka Tyanova et al.

NATURE METHODS (2016)

Article Biochemical Research Methods

Orchestrating high-throughput genomic analysis with Bioconductor

Wolfgang Huber et al.

NATURE METHODS (2015)

Article Biochemical Research Methods

Visualization of LC-MS/MS proteomics data in MaxQuant

Stefka Tyanova et al.

PROTEOMICS (2015)

Article Medicine, Research & Experimental

Glutamatergic Mechanisms Associated with Seizures and Epilepsy

Melissa Barker-Haliski et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2015)

Article Multidisciplinary Sciences

Compromised fidelity of endocytic synaptic vesicle protein sorting in the absence of stonin 2

Natalia L. Kononenko et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Medicine, Research & Experimental

Neuronal Autophagy and Neurodevelopmental Disorders

Kyung-Min Lee et al.

Experimental Neurobiology (2013)

Article Neurosciences

Regulation of Presynaptic Neurotransmission by Macroautophagy

Daniela Hernandez et al.

NEURON (2012)

Article Multidisciplinary Sciences

Localization and quaternary structure of the PKA RIβ holoenzyme

Ronit Ilouz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Cell Biology

Isoform-specific targeting of PKA to multivesicular bodies

Michele E. Day et al.

JOURNAL OF CELL BIOLOGY (2011)

Article Cell Biology

Regulation of the autophagy protein LC3 by phosphorylation

Salvatore J. Cherra et al.

JOURNAL OF CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Nutrient Deprivation Induces Neuronal Autophagy and Implicates Reduced Insulin Signaling in Neuroprotective Autophagy Activation

Jessica E. Young et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Cell Biology

Autophagy promotes synapse development in Drosophila

Wei Shen et al.

JOURNAL OF CELL BIOLOGY (2009)

Article Multidisciplinary Sciences

Neurabin Contributes to Hippocampal Long-Term Potentiation and Contextual Fear Memory

Long-Jun Wu et al.

PLOS ONE (2008)

Article Behavioral Sciences

Development of SHIRPA to characterise the phenotype of gene-targeted mice

JP Hatcher et al.

BEHAVIOURAL BRAIN RESEARCH (2001)

Review Chemistry, Multidisciplinary

Physiological substrates of cAMP-dependent protein kinase

JB Shabb

CHEMICAL REVIEWS (2001)

Article Neurosciences

Tonically active protein kinase A regulates neurotransmitter release at the squid giant synapse

S Hilfiker et al.

JOURNAL OF PHYSIOLOGY-LONDON (2001)