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Article
Biochemical Research Methods
Yulan Liu et al.
Summary: Microfluidic CE is an effective method for determining multiple analytes, and a new microchip with on-chip micropump was developed for fluid velocity adjusting in electrophoretic separations. The method showed great potential for fast and sensitive analysis of complex samples.
Article
Chemistry, Analytical
Zhenna Chen et al.
Summary: A negative magnetophoresis focusing microchip was developed and coupled to ICP-MS for single-cell analysis, achieving high sample throughput. Study on uptake behaviors revealed that MCF-7 cells exhibited more remarkable heterogeneity when treated with ZnO NPs, with lower uptake content compared to Zn2+.
ANALYTICAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
JiaWen Lim et al.
Summary: Flow cytometry based-FRET is a widely used technology for analyzing protein interactions. It allows for quick evaluation of FRET in a large number of cells and provides statistically robust quantification. Recent developments in this field offer promising future perspectives.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemical Research Methods
Edwin D. Lavi et al.
Summary: This study investigates the use of dielectrophoresis (DEP) for measuring the storage-induced changes in the electrical properties of human red blood cells (RBCs). The results show that the cytoplasm conductivity of RBCs decreases while the membrane conductance increases during storage.
Article
Biochemical Research Methods
Chenyang Zhou et al.
Summary: Microfluidic impedance cytometry has great value in biomedical diagnosis. In this study, a novel microfluidic impedance cytometer consisting of sensing electrodes and ground electrodes (GNDs) is demonstrated. The simulation results show a signal enhancement of more than five times with the use of GNDs. Additionally, the linear correlation between impedance at high and low frequencies varies with microparticle size, which can be utilized for microparticle classification. This study can contribute to the optimization of microelectrodes and signal processing in microfluidic impedance analysis.
Article
Chemistry, Analytical
Yali Chen et al.
Summary: The study achieved rapid and effective quantitation of carnosine and nicotinamide in cosmetics by using cyclic olefin copolymer microchips with both dynamic and static coatings. The static coating improved the hydrophilicity of the surface and prevented nonspecific peptide adsorption, while the dynamic coating adjusted flow velocity and enhanced column efficiency. The method showed potential in complex sample analysis.
JOURNAL OF SEPARATION SCIENCE
(2022)
Review
Engineering, Electrical & Electronic
Madhusudan B. Kulkarni et al.
Summary: This article discusses the rapid growth and development of portable, automated, integrated, and miniaturized temperature management systems, particularly in the field of micro fluidic technology. It highlights the importance of microthermofluidic (MTF) systems in various biochemical, biomedical, and biological applications, and the role of precise temperature regulation using different heating methods. The article also reviews advancements in microfluidics and thermal management systems, and presents challenges and future research directions in this area.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Engineering, Electrical & Electronic
Xianming Qin et al.
Summary: In this study, a method was developed to capture Paramecium using an acoustic valve. By adjusting the voltage and inlet pressure, Paramecium can be confined in a narrow space without losing its movement ability. This method has the potential for capturing or sorting micro swimmers in biochemical experiments.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Review
Gastroenterology & Hepatology
Joseph C. Ahn et al.
Summary: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related morbidity and mortality worldwide, and current tests like alpha-fetoprotein have limited accuracy. Liver biopsy, while informative, is not routinely used due to invasiveness, leading to a need for new biomarkers. Liquid biopsy, specifically detection of circulating tumor cells (CTCs), offers potential for early detection and personalized treatment management in HCC patients. Quantitative analysis of CTCs can predict disease prognosis and treatment response, highlighting the importance of developing CTC detection platforms for clinical use.
Review
Biochemistry & Molecular Biology
Karuna Ganesh et al.
Summary: Improved understanding of metastases biology has led to advancements in targeting and treating both micro- and macrometastases. Recent studies have identified the unique biology of metastasis-initiating cells, providing new opportunities for developing more effective treatment strategies through cancer sequencing, mechanistic studies, and clinical trials. These insights offer potential for better outcomes in targeting metastatic relapse and improving patient survival.
Article
Chemistry, Analytical
Yu Wang et al.
Summary: This study developed a microfluidic robot platform for sorting rare target cells from complex clinical blood samples, achieving high efficiency and purity through a novel multi-step sorting strategy. The platform automates the identification, capture, and droplet generation of rare cells, demonstrating the feasibility and potential application in the sorting and analysis of specific rare cells like circulating endothelial progenitor cells (CEPCs) in human blood.
Article
Chemistry, Analytical
Ping Sun et al.
Summary: By investigating microchips with sub-millimeter channels, this study successfully reduced cost and improved ease of operation and separation efficiency, making microchip capillary electrophoresis a viable alternative to conventional slab gel electrophoresis in most biological laboratories.
Review
Biochemical Research Methods
Sonal M. Manohar et al.
Summary: Flow cytometry is a sophisticated technique that utilizes light scattering and fluorescence emission to analyze cells labeled with specific probes. It offers fast, multiparametric analysis at the single cell level and allows physical sorting of cells based on different parameters. Innovative technologies like imaging FCM, mass cytometry, and Raman FCM are being developed to overcome limitations of traditional FCM in this evolving field.
Review
Biophysics
Hossein Safarpour et al.
BIOSENSORS & BIOELECTRONICS
(2020)
Article
Biochemical Research Methods
Arash Dalili et al.
Review
Engineering, Biomedical
Aakash Rajawat et al.
BIOMEDICAL ENGINEERING LETTERS
(2020)
Review
Biochemical Research Methods
Yanli Gong et al.
Article
Biochemical Research Methods
Wanjun Zhou et al.
Review
Oncology
Laura Keller et al.
NATURE REVIEWS CANCER
(2019)
Article
Engineering, Electrical & Electronic
Nishtha Panwar et al.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2018)
Review
Chemistry, Analytical
Ruey-Jen Yang et al.
SENSORS AND ACTUATORS B-CHEMICAL
(2018)
Article
Biochemical Research Methods
Liangliang Sun et al.
JOURNAL OF PROTEOME RESEARCH
(2015)
Review
Biochemical Research Methods
Menake E. Piyasena et al.
