期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 244, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2022.114031
关键词
Polystyrene microplastics (PS-MPs); Diabetic mice; Lipid metabolism; Inflammation
资金
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province
- Research start-up funds for new teachers of Nanjing Normal University
- [21806078]
- [21976087]
- [BK20200011]
This study compares the response of diabetic mice with healthy mice after exposure to polystyrene microplastics (PS-MPs) and highlights the increased sensitivity and potential health risks faced by individuals with chronic diseases. The findings suggest that chronic disease patients, such as those with diabetes, may experience liver damage, abnormal lipid metabolism, and inflammation as a result of MPs exposure.
Human exposure to microplastics (MPs) continues to occur due to ingestion of contaminated food, water and air. Intake of MPs can pose potential health risks by interfering with the production and circulation of nutrients, leading to physiological stress (such as immune responses and metabolic abnormalities). Toxicity data of MPs based on healthy individuals may not be applicable to large populations of patients with chronic diseases rep-resented by diabetes. Therefore, in this study, the response of diabetic mice was compared with that of healthy mice after exposure to polystyrene microplastics (PS-MPs), and interesting differences were observed. PS-MPs exposure significantly increased liver tissue damage, abnormal lipid metabolism, inflammatory effect, liver metabolic disorder and changes of intestinal microbial composition in diabetic mice. Moreover, PS-MPs over-stated abnormal lipid metabolism in diabetic mice. The difference between the increased inflammation after exposure to PS-MPs in healthy and diabetic mice involves that the former is mainly modulated by gut microbes, while diabetic mice seem to be more susceptible to lipid metabolism disturbances. In addition, the size effect of MPs was also observed in diabetic mice. These results suggested that individuals with chronic diseases may be more sensitive to pollution due to altered homeostasis, and therefore disease status should be fully considered when assessing the health risk of pollutants.
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