4.5 Article

Cardiac-specific Trim44 knockout in rat attenuates isoproterenol- induced cardiac remodeling via inhibition of AKT/mTOR pathway

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

LKB1IP promotes pathological cardiac hypertrophy by targeting PTEN/Akt signalling pathway

Mi Tian et al.

Summary: LKB1IP plays a crucial role in stress-induced cardiac hypertrophy, with its deficiency protecting the heart against hypertrophy and fibrosis. LKB1IP affects cardiac hypertrophy development by activating the Akt signaling pathway.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Article Oncology

Zenglv Fumai Granule protects cardiomyocytes against hypoxia/reoxygenation-induced apoptosis via inhibiting TRIM28 expression

Xiao-Hua Zhang et al.

Summary: ZFG attenuates H/R-induced cardiomyocyte apoptosis by regulating the TRIM28/GPX1/ROS pathway, indicating potential therapeutic options for MIR injury.

MOLECULAR MEDICINE REPORTS (2021)

Article Oncology

Circ_0056285 Regulates Proliferation, Apoptosis and Glycolysis of Osteosarcoma Cells via miR-1244/TRIM44 Axis

Shousong Huo et al.

Summary: The study revealed that circ_0056285 promotes osteosarcoma progression by sponging miR-1244 and increasing TRIM44 expression. Silencing circ_0056285 inhibits cell proliferation and promotes apoptosis, suggesting that circ_0056285 could serve as a diagnostic biomarker for osteosarcoma.

CANCER MANAGEMENT AND RESEARCH (2021)

Article Multidisciplinary Sciences

miR-1307 promotes hepatocarcinogenesis by CALR-OSTC-endoplasmic reticulum protein folding pathway

Sijie Xie et al.

Summary: miR-1307 is highly expressed in liver cancer and promotes hepatocarcinogenesis by inhibiting methyltransferase proteins, increasing histone methylation modifications, and affecting cell cycle protein binding abilities.

ISCIENCE (2021)

Article Biochemistry & Molecular Biology

TRIM44 mediated p62 deubiquitination enhances DNA damage repair by increasing nuclear FLNA and 53BP1 expression

Lin Lyu et al.

Summary: Autophagy plays a crucial role in cancer cell survival, while TRIM44 is a key element regulating DNA damage response, increasing DNA damage repair and serving as a potential therapeutic target for therapy-resistant tumor cells with intact autophagy.

ONCOGENE (2021)

Article Biochemistry & Molecular Biology

Novel rat model of multiple mitochondrial dysfunction syndromes (MMDS) complicated with cardiomyopathy

Yahao Ling et al.

Summary: This study established a rat model with Isca1 gene knockout, showing characteristics of dilated cardiomyopathy and typical MMDS features in Isca1 HET rats. The model could be utilized for studying the mechanism of energy metabolism in cardiovascular diseases and drug development.

ANIMAL MODELS AND EXPERIMENTAL MEDICINE (2021)

Article Oncology

TRIM44 facilitates ovarian cancer proliferation, migration, and invasion by inhibiting FRK

Xiu-Zhang Yu et al.

Summary: Our study revealed that TRIM44 facilitates ovarian cancer proliferation, migration, and invasion by inhibiting FRK. The analysis of tissue histotype, patient data, and Kaplan-Meier Curve suggested the crucial roles of TRIM44 and FRK in tumor progression. Knocking down TRIM44 in vitro inhibited OC cells proliferation, migration, and invasion.

NEOPLASMA (2021)

Article Medicine, General & Internal

Tripartite Motif-Containing 44 is Involved in the Tumorigenesis of Laryngeal Squamous Cell Carcinoma, and its Expression is Downregulated by Nuciferine

Qing-Hua Li et al.

Summary: The study showed that overexpressed TRIM44 in laryngeal squamous cell carcinoma could be inhibited effectively by knockdown or nuciferine, leading to suppressed tumor growth. This suggests that targeting TRIM44 could be a potential therapeutic strategy for laryngeal squamous cell carcinoma.

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Article Oncology

Inhibition of SPATS2 Suppresses Proliferation and Invasion of Hepatocellular Carcinoma Cells through TRIM44-STAT3 Signaling Pathway

Lirong Chen et al.

Summary: This study elucidated the significant mechanism of SPATS2-TRIM44-p-STAT3 in HCC and provided a new theoretical basis for targeted therapy, showing that high SPATS2 protein level is indicative of an unfavorable clinicopathological feature and poor prognosis in 112 HCC patients.

JOURNAL OF CANCER (2021)

Article Pathology

Combined A20 and tripartite motif-containing 44 as poor prognostic factors for breast cancer patients of the Japanese population

Junichiro Sato et al.

Summary: The combined immunoreactivity of A20 and TRIM44 predicts the prognosis of patients with invasive breast cancer, with a double-positive status associated with shorter disease-free survival. Additionally, the positive correlation between A20 and TRIM44 immunoreactivities suggests that TRIM44's activation of NF-kappa B signaling may occur in clinical breast cancer tissues.

PATHOLOGY INTERNATIONAL (2021)

Article Cardiac & Cardiovascular Systems

Genetic and functional implications of an exonic TRIM55 variant in heart failure

Juho Heliste et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)

Article Medicine, Research & Experimental

Myocardial tissue-specific Dnmt1 knockout in rats protects against pathological injury induced by Adriamycin

Tong-Tong Wu et al.

LABORATORY INVESTIGATION (2020)

Review Cardiac & Cardiovascular Systems

Emerging Role of TRIM Family Proteins in Cardiovascular Disease

Jing-rui Zhang et al.

CARDIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Mutations in TRIM63 cause an autosomal-recessive form of hypertrophic cardiomyopathy

Joel Salazar-Mendiguchia et al.

Article Cell Biology

Tripartite motif 10 regulates cardiac hypertrophy by targeting the PTEN/AKT pathway

Hui Yang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Editorial Material Cardiac & Cardiovascular Systems

Editorial Commentary: Dichotomous actions of the E3-ligase Ring TRIMmers in cardiac myocytes

Inna Rabinovich-Nikitin et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2019)

Article Cardiac & Cardiovascular Systems

A systematic view on E3 ligase Ring TRIMmers with a focus on cardiac function and disease

Ankush Borlepawar et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2019)

Article Oncology

TRIM44 activates the AKT/mTOR signal pathway to induce melanoma progression by stabilizing TLR4

Chuan-Yuan Wei et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Review Biochemistry & Molecular Biology

TRIMming down to TRIM37: Relevance to Inflammation, Cardiovascular Disorders, and Cancer in MULIBREY Nanism

Benjamin Brigant et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Cardiac & Cardiovascular Systems

New Molecular Mechanism Underlying Myc-Mediated Cytochrome P450 2E1 Upregulation in Apoptosis and Energy Metabolism in the Myocardium

Feifei Guan et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2019)

Article Biotechnology & Applied Microbiology

TRIM44 Promotes Colorectal Cancer Proliferation, Migration, and Invasion Through the Akt/mTOR Signaling Pathway

Chun-guang Li et al.

ONCOTARGETS AND THERAPY (2019)

Article Pathology

High TRIM44 expression in endometrial carcinoma is associated with a poorer patient outcome

Panpan Li et al.

PATHOLOGY RESEARCH AND PRACTICE (2018)

Review Ophthalmology

The genetics of congenital aniridia-a guide for the ophthalmologist

Erlend S. Landsend et al.

SURVEY OF OPHTHALMOLOGY (2018)

Article Cardiac & Cardiovascular Systems

Meox1 accelerates myocardial hypertrophic decompensation through Gata4

Dan Lu et al.

CARDIOVASCULAR RESEARCH (2018)

Article Biochemistry & Molecular Biology

TRIM44 Is a Poor Prognostic Factor for Breast Cancer Patients as a Modulator of NF-B Signaling

Hidetaka Kawabata et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Ophthalmology

PAX6 aniridia syndrome: clinics, genetics, and therapeutics

Hyun Taek Lim et al.

CURRENT OPINION IN OPHTHALMOLOGY (2017)

Article Medicine, Research & Experimental

Dkk3 prevents familial dilated cardiomyopathy development through Wnt pathway

Dan Lu et al.

LABORATORY INVESTIGATION (2016)

Article Medicine, Research & Experimental

Tripartite motif 32 prevents pathological cardiac hypertrophy

Lijuan Chen et al.

CLINICAL SCIENCE (2016)

Review Cardiac & Cardiovascular Systems

Physiological and pathological cardiac hypertrophy

Ippei Shimizu et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2016)

Review Ophthalmology

Congenital aniridia: etiology, manifestations and management

Monica Samant et al.

EXPERT REVIEW OF OPHTHALMOLOGY (2016)

Article Genetics & Heredity

Variants in TRIM44 Cause Aniridia by Impairing PAX6 Expression

Xibo Zhang et al.

HUMAN MUTATION (2015)

Review Peripheral Vascular Disease

Interferon Regulatory Factor Signalings in Cardiometabolic Diseases

Xiao-Jing Zhang et al.

HYPERTENSION (2015)

Review Pharmacology & Pharmacy

The critical role of Akt in cardiovascular function

Prasanna Abeyrathna et al.

VASCULAR PHARMACOLOGY (2015)

Letter Cell Biology

Generating rats with conditional alleles using CRISPR/Cas9

Yuanwu Ma et al.

CELL RESEARCH (2014)

Article Genetics & Heredity

Array CGH analysis of a cohort of Russian patients with intellectual disability

Anna A. Kashevarova et al.

Article Cardiac & Cardiovascular Systems

Calponin1 inhibits dilated cardiomyopathy development in mice through the εPKC pathway

Dan Lu et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2014)

Editorial Material Oncology

TRIMing the Patient Population to Increase the Benefit of mTOR Inhibition

H. Ian Robins et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2014)

Article Oncology

Amplification of TRIM44: Pairing a Prognostic Target With Potential Therapeutic Strategy

Chin-Ann Johnny Ong et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2014)

Review Medicine, Research & Experimental

Signaling effectors underlying pathologic growth and remodeling of the heart

Jop H. van Berlo et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Immunology

Novel Function of Trim44 Promotes an Antiviral Response by Stabilizing VISA

Bo Yang et al.

JOURNAL OF IMMUNOLOGY (2013)

Review Pathology

Regulation of AMPK by the Ubiquitin Proteasome System

Makhosazane Zungu et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

Review Oncology

TRIM proteins and cancer

Shigetsugu Hatakeyama

NATURE REVIEWS CANCER (2011)

Article Biochemistry & Molecular Biology

TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase

Tomohiko Urano et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Article Multidisciplinary Sciences

Distinct roles of GSK-3α and GSK-3β phosphorylation in the heart under pressure overload

Takahisa Matsuda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Cell Biology

Regulation of cardiac hypertrophy by intracellular signalling pathways

Joerg Heineke et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Article Medicine, Research & Experimental

Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure

I Shiojima et al.

JOURNAL OF CLINICAL INVESTIGATION (2005)

Article Cardiac & Cardiovascular Systems

Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt

T Matsui et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2005)

Review Cardiac & Cardiovascular Systems

Negative regulators of cardiac hypertrophy

SE Hardt et al.

CARDIOVASCULAR RESEARCH (2004)

Review Cell Biology

When ubiquitin meets ubiquitin receptors: a signalling connection

PP Di Fiore et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)

Article Cardiac & Cardiovascular Systems

Rapamycin attenuates load-induced cardiac hypertrophy in mice

T Shioi et al.

CIRCULATION (2003)

Review Physiology

Cardiac hypertrophy: The good, the bad and the ugly

N Frey et al.

ANNUAL REVIEW OF PHYSIOLOGY (2003)

Article Neurosciences

Isolation of a mouse brain cDNA expressed in developing neuroblasts and mature neurons

E Boutou et al.

MOLECULAR BRAIN RESEARCH (2001)