期刊
DIFFERENTIATION
卷 128, 期 -, 页码 26-32出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.diff.2022.09.003
关键词
Hox; Neural crest; ECM; EMT; Integrin
资金
- Cancer Prevention and Research Institute of Texas (CPRIT) [CPRIT-RR170062]
- NSF CAREER Award [1942019]
- National Institutes of Health [DK124804]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1942019] Funding Source: National Science Foundation
This review discusses the process of neural crest epithelial-to-mesenchymal transition (EMT) and the roles of extracellular matrix (ECM) and cellular effector proteins in the migration of neural crest cells. It also introduces the regulation of EMT and ECM remodeling during neural crest cell ontogenesis by Hox transcription factors.
Emerging during embryogenesis, the neural crest are a migratory, transient population of multipotent stem cell that differentiates into various cell types in vertebrates. Neural crest cells arise along the anterior-posterior extent of the neural tube, delaminate and migrate along routes to their final destinations. The factors that orchestrate how neural crest cells undergo delamination and their subsequent sustained migration is not fully understood. This review provides a primer about neural crest epithelial-to-mesenchymal transition (EMT), with a special emphasis on the role of the Extracellular matrix (ECM), cellular effector proteins of EMT, and subsequent migration. We also summarize published findings that link the expression of Hox transcription factors to EMT and ECM modification, thereby implicating Hox factors in regulation of EMT and ECM remodeling during neural crest cell ontogenesis.
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