期刊
DIABETOLOGIA
卷 66, 期 1, 页码 57-69出版社
SPRINGER
DOI: 10.1007/s00125-022-05797-0
关键词
Antioxidative defence; ER stress; Hyperbaric oxygen therapy; Insulin resistance; Mitohormesis
This study aimed to examine the effects of hyperbaric oxygen therapy on whole-body glucose metabolism in individuals with type 2 diabetes. The results showed that hyperbaric oxygen therapy decreased fasting blood glucose, improved whole-body insulin sensitivity, and achieved this improvement through decreasing endoplasmic reticulum stress and increasing mitochondrial function.
Aims/hypothesis Hyperbaric oxygen (HBO) therapy may improve hyperglycaemia in humans with type 2 diabetes, but underlying mechanisms are unclear. Our objective was to examine the glucometabolic effects of HBO on whole-body glucose disposal in humans with type 2 diabetes. Methods In a randomised placebo-controlled crossover trial located at the German Diabetes Center, 12 male individuals with type 2 diabetes (age 18-75 years, BMI <35 kg/m(2), HbA(1c) 42-75 mmol/mol [6-9%]), randomly allocated by one person, underwent 2-h HBO, once with 100% (240 kPa; HBO) and once with 21% oxygen (240 kPa; control, CON). Insulin sensitivity was assessed by hyperinsulinaemic-euglycaemic clamps with d-[6,6-H-2(2)]glucose, hepatic and skeletal muscle energy metabolism were assessed by H-1/P-31-magnetic resonance spectroscopy, while high-resolution respirometry measured skeletal muscle and white adipose tissue (WAT) mitochondrial capacity. All participants and people assessing the outcomes were blinded. Results HBO decreased fasting blood glucose by 19% and increased whole-body, hepatic and WAT insulin sensitivity about one-third (p<0.05 vs CON). Upon HBO, hepatic gamma-ATP concentrations doubled, mitochondrial respiratory control doubled in skeletal muscle and tripled in WAT (p<0.05 vs CON). HBO increased myocellular insulin-stimulated serine-473/threonine-308 phosphorylation of Akt but decreased basal inhibitory serine-1101 phosphorylation of IRS-1 and endoplasmic reticulum stress (p<0.05 vs CON). Conclusions/interpretation HBO-mediated improvement of insulin sensitivity likely results from decreased endoplasmicreticulum stress and increased mitochondrial capacity, possibly leading to low-dose reactive oxygen species-mediated mitohormesis in humans with type 2 diabetes.
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