The presence of sodium glucose co-transporter 2 in mesangial cells and pericytes and its roles in mesangial lesions and in capillaries under diabetic and ischemic conditions

SGLT2 is expressed in mesangial cells and pericytes, and is upregulated by high glucose and ischemia. Upregulated SGLT2 in both cells might directly worsen ischemia in kidney interstitial legion, heart and brain. The overexpression of SGLT2 in these cells could induce various organ failures via damages or loss of capillaries and dysfunctions of mesangial cells, which are attenuated by SGLT2 inhibitors.

Automated summary

SGLT2 is upregulated in mesangial cells and pericytes due to high glucose and ischemia, which can directly exacerbate ischemia in the kidney interstitial legion, heart, and brain. The overexpression of SGLT2 in these cells can lead to organ failures through damages or loss of capillaries and dysfunctions of mesangial cells, which can be attenuated by SGLT2 inhibitors.