Metabolic profile-based subgroups can identify differences in brain volumes and brain iron deposition

Article Nutrition & Dietetics

Vitamin D and brain health: an observational and Mendelian randomization study

Shreeya S. Navale et al.

Summary: This study found an association between low vitamin D status and neuroimaging outcomes, as well as the risks of dementia and stroke. Vitamin D deficiency may increase the risk of dementia, but has no effect on stroke risk.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2022)

添加到收藏夹

Article Nutrition & Dietetics

Associations of vitamin D deficiency with MRI markers of brain health in a community sample

Pauline H. Croll et al.

Summary: The study found an association between vitamin D deficiency and smaller brain tissue volume and hippocampus volume, with no association seen with grey matter volume, white matter integrity, or CSVD markers. Further research, particularly with a longitudinal design, is needed to clarify the role of vitamin D in neurodegeneration.

CLINICAL NUTRITION (2021)

添加到收藏夹

Review Cell Biology

Relationship between obesity and structural brain abnormality: Accumulated evidence from observational studies

Yi-Peng Han et al.

Summary: The study found an association between obesity/overweight and structural brain abnormalities, with BMI and WC relating to brain structure and hippocampal volume. However, in longitudinal studies, BMI showed no significant association with overall brain structural abnormalities, while WC and WHR were linked to lacunar infarcts and WMH.

AGEING RESEARCH REVIEWS (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Midlife blood pressure is associated with the severity of white matter hyperintensities: analysis of the UK Biobank cohort study

Karolina Agnieszka Wartolowska et al.

Summary: The study found that white matter hyperintensities (WMH) are closely related to concurrent and past hypertension, especially with regard to systolic blood pressure. However, before the age of 50, diastolic blood pressure is more strongly correlated with WMH. Long-term prevention of WMH may require control of even mildly elevated midlife diastolic blood pressure.

EUROPEAN HEART JOURNAL (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Healthy dietary intake moderates the effects of age on brain iron concentration and working memory performance

Valentinos Zachariou et al.

Summary: Certain nutrients may reduce brain iron concentration and slow the rate of brain iron accumulation and working memory declines in aging adults.

NEUROBIOLOGY OF AGING (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Unlocking the causal link of metabolically different adiposity subtypes with brain volumes and the risks of dementia and stroke: A Mendelian randomization study

Anwar Mulugeta et al.

Summary: Through Mendelian randomization analysis, it was found that adiposity-related metabolic abnormalities may contribute to decreased gray matter volume, but no causal relationship was observed with white matter and hippocampal volume, white matter hyperintensities, dementia, and stroke risk.

NEUROBIOLOGY OF AGING (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Association Between Gamma-Glutamyl Transferase and Mild Cognitive Impairment in Chinese Women

Zhaoyang Tang et al.

Summary: Elevated Gamma-Glutamyl Transferase (GGT) levels in women are associated with a higher risk of mild cognitive impairment (MCI), especially when they are obese, sleep deprived, have high serum uric acid levels, or have undergone menopause.

FRONTIERS IN AGING NEUROSCIENCE (2021)

添加到收藏夹

Review Neurosciences

Obesity and Gray Matter Volume Assessed by Neuroimaging: A Systematic Review

Marina Fernandez-Andujar et al.

Summary: Obesity is associated with a decrease in gray matter volume, potentially increasing the risk of cognitive impairment and dementia.

BRAIN SCIENCES (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Midlife blood pressure is associated with the severity of white matter hyperintensities: analysis of the UK Biobank cohort study

Karolina Agnieszka Wartolowska et al.

Summary: This study found a strong association between WMH and concurrent/past elevated blood pressure, particularly with a stronger association with systolic blood pressure (SBP). However, before the age of 50, diastolic blood pressure (DBP) was more strongly associated with WMH. Long-term prevention of WMH may require control of even mildly elevated midlife DBP.

EUROPEAN HEART JOURNAL (2021)

添加到收藏夹

Article Geriatrics & Gerontology