期刊
DIABETES OBESITY & METABOLISM
卷 25, 期 1, 页码 121-131出版社
WILEY
DOI: 10.1111/dom.14853
关键词
brain iron; brain volume; metabolic profiling; self-organizing map; white matter hyperintensities
This study evaluated the associations between metabolic subgroups and biomarkers with brain MRI measures, and found differential associations between metabolism and biomarkers with brain neuroimaging characteristics. These findings may provide insights into the early risk factors associated with dementia.
Aims To evaluate associations of metabolic profiles and biomarkers with brain atrophy, lesions, and iron deposition to understand the early risk factors associated with dementia. Materials and methods Using data from 26 239 UK Biobank participants free from dementia and stroke, we assessed the associations of metabolic subgroups, derived using an artificial neural network approach (self-organizing map), and 39 individual biomarkers with brain MRI measures: total brain volume (TBV), grey matter volume (GMV), white matter volume (WMV), hippocampal volume (HV), white matter hyperintensity (WMH) volume, and caudate iron deposition. Results In metabolic subgroup analyses, participants characterized by high triglycerides and liver enzymes showed the most adverse brain outcomes compared to the healthy reference subgroup with high-density lipoprotein cholesterol and low body mass index (BMI) including associations with GMV (beta(standardized) -0.20, 95% confidence interval [CI] -0.24 to -0.16), HV (beta(standardized) -0.09, 95% CI -0.13 to -0.04), WMH volume (beta(standardized) 0.22, 95% CI 0.18 to 0.26), and caudate iron deposition (beta(standardized) 0.30, 95% CI 0.25 to 0.34), with similar adverse associations for the subgroup with high BMI, C-reactive protein and cystatin C, and the subgroup with high blood pressure (BP) and apolipoprotein B. Among the biomarkers, striking associations were seen between basal metabolic rate (BMR) and caudate iron deposition (beta(standardized) 0.23, 95% CI 0.22 to 0.24 per 1 SD increase), GMV (beta(standardized) -0.15, 95% CI -0.16 to -0.14) and HV (beta(standardized) -0.11, 95% CI -0.12 to -0.10), and between BP and WMH volume (beta(standardized) 0.13, 95% CI 0.12 to 0.14 for diastolic BP). Conclusions Metabolic profiles were associated differentially with brain neuroimaging characteristics. Associations of BMR, BP and other individual biomarkers may provide insights into actionable mechanisms driving these brain associations.
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