☆ 4.7 Editorial Material

A limb bud morphogen bites the dust

DEVELOPMENTAL CELL (2022)

GLI transcriptional repression is inert prior to Hedgehog pathway activation

Rachel K. Lex et al.

Summary: The study challenges the current understanding that GLI3 repression is established before Hedgehog (HH) signaling and demonstrates that GLI3 is inert in the limb bud before HH onset. The loss of Gli3 does not increase target gene expression or accessibility, contrasting with post-HH signaling. GLI repression is established independently of HH signaling, but after its onset.

NATURE COMMUNICATIONS (2022)

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Article Cell Biology

Sonic hedgehog is not a limb morphogen but acts as a trigger to specify all digits in mice

Jianjian Zhu et al.

Summary: This study demonstrates that a transient, early pulse of Sonic hedgehog (Shh) is necessary and sufficient for normal mouse limb development, bypassing the requirement for cell survival. Shh response is short range and limited to a specific time window and region, and it patterns digit identities indirectly.

DEVELOPMENTAL CELL (2022)

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Article Developmental Biology