期刊
DEVELOPMENT
卷 149, 期 19, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.200785
关键词
Cnidaria; Nematostella; Axial patterning; Gastrulation
资金
- Austrian Science Foundation (FWF) [P30404-B29]
This study investigated the role of cWnt signaling in the oral-aboral axis patterning in the cnidarian Nematostella vectensis, revealing the partial redundancy of all four Frizzled receptors in this process. However, their involvement in endoderm specification was not observed.
Canonical Wnt (cWnt) signalling is involved in a plethora of basic developmental processes such as endomesoderm specification, gastrulation and patterning the main body axis. To activate the signal, Wnt ligands form complexes with LRP5/6 and Frizzled receptors, which leads to nuclear translocation of beta-catenin and a transcriptional response. In Bilateria, the expression of different Frizzled genes is often partially overlapping, and their functions are known to be redundant in several developmental contexts. Here, we demonstrate that all four Frizzled receptors take part in the cWnt-mediated oralaboral axis patterning in the cnidarian Nematostella vectensis but show partially redundant functions. However, we do not see evidence for their involvement in the specification of the endoderm - an earlier event likely relying on maternal intracellular p-catenin signalling components. Finally, we demonstrate that the main Wnt ligands crucial for the early oral-aboral patterning are Wnt1, Wnt3 and Wnt4. Comparison of our data with knowledge from other models suggests that distinct but overlapping expression domains and partial functional redundancy of cnidarian and bilaterian Frizzled genes may represent a shared ancestral trait.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据