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Alternative pathways driven by STING: From innate immunity to lipid metabolism

期刊

CYTOKINE & GROWTH FACTOR REVIEWS
卷 68, 期 -, 页码 54-68

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2022.08.006

关键词

STING; Inflammation; Innate immunity; Lipid metabolism; Metabolism

资金

  1. Agence Nationale de Recherche sur le SIDA et les Hepatites virales (ANRS) [ECTZ117448]
  2. fondation ARC pour la recherche sur le cancer
  3. Region Languedoc Roussillon
  4. Centre Nationale pour la Recherche Scientifique (CNRS)
  5. French gouvernement within the Plan d'investissements France 2030 (LabMUSE EpiGenMed)
  6. CNRS
  7. LabMuse EpiGenMed from the French government within the Plan d'investissements France
  8. Lundbeck Foundation [R335-2019-2138]
  9. Kraeftens Bekaempelse [R279-A16218, R302-A17296]
  10. Independent Research Fund Denmark [1026-00003B]
  11. Brodrene Hartman Fonden
  12. Horslev Fonden
  13. Einar Willumsens mindelegat
  14. Eva og Henry Fraenkels mindefond
  15. Beckett Fonden
  16. Lily Benthine Lunds fonden
  17. Sofus Carl Emil Friis Legat
  18. Lundbeckfonden [R307-2018-3667]
  19. Carlsberg Fonden [CF19-0687]
  20. A. P. Moller Fonden [20-L-0317]
  21. Riisfort Fonden
  22. Steno Diabetes Center Aarhus (SDCA)

向作者/读者索取更多资源

STING, a major adaptor protein, not only plays a central role in controlling immune responses, but also plays a key role in controlling metabolic pathways. These findings deepen our understanding of STING's involvement in human pathologies.
The Stimulator of Interferon Genes (STING) is a major adaptor protein that is central to the initiation of type I interferon responses and proinflammatory signalling. STING-dependent signalling is triggered by the presence of cytosolic nucleic acids that are generated following pathogen infection or cellular stress. Beyond this central role in controlling immune responses through the production of cytokines and chemokines, recent reports have uncovered inflammation-independent STING functions. Amongst these, a rapidly growing body of evidence demonstrates a key role of STING in controlling metabolic pathways at several levels. Since immunity and metabolic homeostasis are tightly interconnected, these findings deepen our understanding of the involvement of STING in human pathologies. Here, we discuss these findings and reflect on their impact on our current un-derstanding of how nucleic acid immunity controls homeostasis and promotes pathological outcomes.

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