期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 68, 期 -, 页码 54-68出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2022.08.006
关键词
STING; Inflammation; Innate immunity; Lipid metabolism; Metabolism
资金
- Agence Nationale de Recherche sur le SIDA et les Hepatites virales (ANRS) [ECTZ117448]
- fondation ARC pour la recherche sur le cancer
- Region Languedoc Roussillon
- Centre Nationale pour la Recherche Scientifique (CNRS)
- French gouvernement within the Plan d'investissements France 2030 (LabMUSE EpiGenMed)
- CNRS
- LabMuse EpiGenMed from the French government within the Plan d'investissements France
- Lundbeck Foundation [R335-2019-2138]
- Kraeftens Bekaempelse [R279-A16218, R302-A17296]
- Independent Research Fund Denmark [1026-00003B]
- Brodrene Hartman Fonden
- Horslev Fonden
- Einar Willumsens mindelegat
- Eva og Henry Fraenkels mindefond
- Beckett Fonden
- Lily Benthine Lunds fonden
- Sofus Carl Emil Friis Legat
- Lundbeckfonden [R307-2018-3667]
- Carlsberg Fonden [CF19-0687]
- A. P. Moller Fonden [20-L-0317]
- Riisfort Fonden
- Steno Diabetes Center Aarhus (SDCA)
STING, a major adaptor protein, not only plays a central role in controlling immune responses, but also plays a key role in controlling metabolic pathways. These findings deepen our understanding of STING's involvement in human pathologies.
The Stimulator of Interferon Genes (STING) is a major adaptor protein that is central to the initiation of type I interferon responses and proinflammatory signalling. STING-dependent signalling is triggered by the presence of cytosolic nucleic acids that are generated following pathogen infection or cellular stress. Beyond this central role in controlling immune responses through the production of cytokines and chemokines, recent reports have uncovered inflammation-independent STING functions. Amongst these, a rapidly growing body of evidence demonstrates a key role of STING in controlling metabolic pathways at several levels. Since immunity and metabolic homeostasis are tightly interconnected, these findings deepen our understanding of the involvement of STING in human pathologies. Here, we discuss these findings and reflect on their impact on our current un-derstanding of how nucleic acid immunity controls homeostasis and promotes pathological outcomes.
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