期刊
CURRENT TREATMENT OPTIONS IN ONCOLOGY
卷 23, 期 11, 页码 1535-1547出版社
SPRINGER
DOI: 10.1007/s11864-022-01015-6
关键词
Autophagy; Children; Central nervous system tumors; Cell death; Chemosensitivity; Radiosensitivity
类别
资金
- University of Gothenburg
- National Natural Science Foundation of China [82003396]
- Swedish Cancer Foundation [CAN2017/509, 20-1121-PjF]
- Swedish Childhood Cancer Foundation [PR2018-0082, PR2021-0020]
- Henan Medical Science and Technique Foundation [212102310221, LHCJ20190337]
- Henan Provincial Science and Technology Research Project [222102310431]
- Henan Key Laboratory of Population Defects Prevention [2021-03]
- national Health Commission Key Laboratory of Birth Defects Prevention
Autophagy is a physiological process that plays a complex role in cancer. Understanding autophagy mechanisms is important for the treatment of pediatric central nervous system tumors.
Opinion statement Autophagy is a physiological process that occurs in normal tissues. Under external environmental pressure or internal environmental changes, cells can digest part of their contents through autophagy in order to reduce metabolic pressure or remove damaged organelles. In cancer, autophagy plays a paradoxical role, acting as a tumor suppressor-by removing damaged organelles and inhibiting inflammation or by promoting genome stability and the tumor-adaptive responses-as a pro-survival mechanism to protect cells from stress. In this article, we review the autophagy-dependent mechanisms driving childhood central nervous system tumor cell death, malignancy invasion, chemosensitivity, and radiosensitivity. Autophagy inhibitors and inducers have been developed, and encouraging results have been achieved in autophagy modulation, suggesting that these might be potential therapeutic agents for the treatment of pediatric central nervous system (CNS) tumors.
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