相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Alz-Disc: A Tool to Discriminate Disease-causing and Neutral Mutations in Alzheimer's Disease
A. Kulandaisamy et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2023)
Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer's disease
Jiansong Fang et al.
ALZHEIMERS RESEARCH & THERAPY (2022)
Transcription factor EB: an emerging drug target for neurodegenerative disorders
Ju-Xian Song et al.
DRUG DISCOVERY TODAY (2021)
Increased isoform-specific phosphodiesterase 4D expression is associated with pathology and cognitive impairment in Alzheimer's disease
Dean Paes et al.
NEUROBIOLOGY OF AGING (2021)
Sigma-1 and Sigma-2 Receptor Modulators as Potential Therapeutics for Alzheimer’s Disease
Robert B. Kargbo
ACS Medicinal Chemistry Letters (2021)
Multimodal single-cell/nucleus RNA sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications for drug repurposing in Alzheimer's disease
Jielin Xu et al.
GENOME RESEARCH (2021)
Tau fibril with membrane lipids: Insight from computational modeling and simulations
Prechiel A. Barredo et al.
PLOS ONE (2021)
Multiomics Identification of Potential Targets for Alzheimer Disease and Antrocin as a Therapeutic Candidate
Alexander T. H. Wu et al.
PHARMACEUTICS (2021)
Exploring Common Therapeutic Targets for Neurodegenerative Disorders Using Transcriptome Study
S. Akila Parvathy Dharshini et al.
FRONTIERS IN GENETICS (2021)
Anti-LINGO-1 antibody ameliorates cognitive impairment, promotes adult hippocampal neurogenesis, and increases the abundance of CB1R-rich CCK-GABAergic interneurons in AD mice
Qi He et al.
NEUROBIOLOGY OF DISEASE (2021)
Computational Drug Repurposing for Alzheimer's Disease Using Risk Genes From GWAS and Single-Cell RNA Sequencing Studies
Yun Xu et al.
FRONTIERS IN PHARMACOLOGY (2021)
Alzheimer's disease drug development pipeline: 2021
Jeffrey Cummings et al.
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS (2021)
LINCS Data Portal 2.0: next generation access point for perturbation-response signatures
Vasileios Stathias et al.
NUCLEIC ACIDS RESEARCH (2020)
Pred-MutHTP: Prediction of disease-causing and neutral mutations in human transmembrane proteins
A. Kulandaisamy et al.
HUMAN MUTATION (2020)
Benchmarking analysis of deleterious SNP prediction tools on CYP2D6 enzyme
Karla Cristina do Vale Ferreira et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2020)
Neurodegenerative Diseases - Is Metabolic Deficiency the Root Cause?
Vignayanandam Ravindernath Muddapu et al.
FRONTIERS IN NEUROSCIENCE (2020)
VEPAD - Predicting the effect of variants associated with Alzheimer's disease using machine learning
Uday Rangaswamy et al.
COMPUTERS IN BIOLOGY AND MEDICINE (2020)
Specific interactions between tau protein and curcumin derivatives: Molecular docking and ab initio molecular orbital simulations
Riku Sato et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2020)
Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease
Marta Olah et al.
NATURE COMMUNICATIONS (2020)
Unraveling Targetable Systemic and Cell-Type-Specific Molecular Phenotypes of Alzheimer's and Parkinson's Brains With Digital Cytometry
Marie C. Bordone et al.
FRONTIERS IN NEUROSCIENCE (2020)
In Silico Molecular Docking Analysis of Potential Anti-Alzheimer's Compounds Present in Chloroform Extract of Carissa carandas Leaf Using Gas Chromatography MS/MS
Srinivasa Rao Kareti et al.
CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL (2020)
Structure Based Design and Molecular Docking Studies for Phosphorylated Tau Inhibitors in Alzheimer's Disease
Jangampalli Adi Pradeepkiran et al.
CELLS (2019)
Molecular docking of Aβ1-40 peptide and its Iowa D23N mutant using small molecule inhibitors: Possible mechanisms of Aβ-peptide inhibition
Rizwan Hasan Khan et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)
Single-cell transcriptomic analysis of Alzheimer's disease
Hansruedi Mathys et al.
NATURE (2019)
Computing the Pathogenicity of Wilson's Disease ATP7B Mutations: Implications for Disease Prevalence
Ning Tang et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2019)
A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation
Alexandra Grubman et al.
NATURE NEUROSCIENCE (2019)
CADD: predicting the deleteriousness of variants throughout the human genome
Philipp Rentzsch et al.
NUCLEIC ACIDS RESEARCH (2019)
Investigating the energy crisis in Alzheimer disease using transcriptome study
S. Akila P. Arvathy Dharshini et al.
SCIENTIFIC REPORTS (2019)
Molecular Insights into Destabilization of Alzheimer's Aβ Protofibril by Arginine Containing Short Peptides: A Molecular Modeling Approach
Sagar S. Barale et al.
ACS OMEGA (2019)
Increased astroglial activity and reduced neuronal function across brain in AβPP-PS1 mouse model of Alzheimer's disease
Anant B. Patel et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2018)
Molecular Docking and Dynamic Simulation of AZD3293 and Solanezumab Effects Against BACE1 to Treat Alzheimer's Disease
Mubashir Hassan et al.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE (2018)
New insights into the role of TREM2 in Alzheimer's disease
Maud Gratuze et al.
MOLECULAR NEURODEGENERATION (2018)
Old Drugs as New Treatments for Neurodegenerative Diseases
Fernando Duraes et al.
PHARMACEUTICALS (2018)
FATHMM-XF: accurate prediction of pathogenic point mutations via extended features
Mark F. Rogers et al.
BIOINFORMATICS (2018)
Reactive Oxygen Species-Mediated Loss of Synaptic Akt1 Signaling Leads to Deficient Activity-Dependent Protein Translation Early in Alzheimer's Disease
Faraz Ahmad et al.
ANTIOXIDANTS & REDOX SIGNALING (2017)
Drug candidates in clinical trials for Alzheimer's disease
Shih-Ya Hung et al.
JOURNAL OF BIOMEDICAL SCIENCE (2017)
Molecular docking based virtual screening of natural compounds as potential BACE1 inhibitors: 3D QSAR pharmacophore mapping and molecular dynamics analysis
Akhil Kumar et al.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2016)
Exploring preferred amino acid mutations in cancer genes: Applications to identify potential drug targets
P. Anoosha et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)
Variation Interpretation Predictors: Principles, Types, Performance, and Choice
Abhishek Niroula et al.
HUMAN MUTATION (2016)
The Ca2+/Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft
Kathrina L. Marcelo et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2016)
The Genotype-Tissue Expression (GTEx) Project
Latarsha J. Carithers et al.
BIOPRESERVATION AND BIOBANKING (2015)
Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons
Consiglia Pacelli et al.
CURRENT BIOLOGY (2015)
Discrimination of driver and passenger mutations in epidermal growth factor receptor in cancer
P. Anoosha et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2015)
Role of TGFβ signaling in the pathogenesis of Alzheimer's disease
Rommy von Bernhardi et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2015)
The Genotype-Tissue Expression (GTEx) Project
Latarsha J. Carithers et al.
BIOPRESERVATION AND BIOBANKING (2015)
Selective alterations of neurons and circuits related to early memory loss in Alzheimer's disease
Maria Llorens-Martin et al.
FRONTIERS IN NEUROANATOMY (2014)
The potential of epigenetic therapies in neurodegenerative diseases
Fabio Coppede
FRONTIERS IN GENETICS (2014)
Identifying Mendelian disease genes with the Variant Effect Scoring Tool
Hannah Carter et al.
BMC GENOMICS (2013)
Predicting the Functional, Molecular, and Phenotypic Consequences of Amino Acid Substitutions using Hidden Markov Models
Hashem A. Shihab et al.
HUMAN MUTATION (2013)
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Jean-Charles Lambert et al.
NATURE GENETICS (2013)
Signals from the lysosome: a control centre for cellular clearance and energy metabolism
Carmine Settembre et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Chia-Chan Liu et al.
NATURE REVIEWS NEUROLOGY (2013)
The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation
Georges Mairet-Coello et al.
NEURON (2013)
The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease
Eleftheria K. Pissadaki et al.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE (2013)
Living on the edge with too many mouths to feed: Why dopamine neurons die
J. Paul Bolam et al.
MOVEMENT DISORDERS (2012)
NR2B-Containing NMDA Receptors Expression and Their Relationship to Apoptosis in Hippocampus of Alzheimer's Disease-Like Rats
Zhi'an Liu et al.
NEUROCHEMICAL RESEARCH (2012)
SIFT web server: predicting effects of amino acid substitutions on proteins
Ngak-Leng Sim et al.
NUCLEIC ACIDS RESEARCH (2012)
Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models
Yadong Huang
BIOCHEMICAL SOCIETY TRANSACTIONS (2011)
A new disease-specific machine learning approach for the prediction of cancer-causing missense variants
Emidio Capriotti et al.
GENOMICS (2011)
Disruption of Neurovascular Unit Prior to Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis
Kazunori Miyazaki et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2011)
Do common in silico tools predict the clinical consequences of amino-acid substitutions in the CFTR gene?
R. Dorfman et al.
CLINICAL GENETICS (2010)
Prazosin for the Treatment of Behavioral Symptoms in Patients With Alzheimer Disease With Agitation and Aggression
Lucy Y. Wang et al.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2009)
The Role of Metabolic Disorders in Alzheimer Disease and Vascular Dementia Two Roads Converged
Suzanne Craft
ARCHIVES OF NEUROLOGY (2009)
Mild Cognitive Impairment and Alzheimer Disease: Patterns of Altered Cerebral Blood Flow at MR Imaging
Weiying Dai et al.
RADIOLOGY (2009)
Role of the region 23-28 in Aβ fibril formation:: Insights from simulations of the monomers and dimers of Alzheimer's peptides Aβ40 and Aβ42
Adrien Melquiond et al.
CURRENT ALZHEIMER RESEARCH (2008)
Histone deacetylase inhibitors: Overview and perspectives
Milos Dokmanovic et al.
MOLECULAR CANCER RESEARCH (2007)
Vascular oxidative stress in Alzheimer disease
Xiongwei Zhu et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2007)
A genome wide analysis of ubiquitin ligases in APP processing identifies a novel regulator of BACE1 mRNA levels
Amy S. Espeseth et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2006)
Differential expression of NMDA receptor subunits and splice variants among the CA1, CA3 and dentate gyrus of the adult rat
SJ Coultrap et al.
MOLECULAR BRAIN RESEARCH (2005)
AMPA exposures induce mitochondrial Ca2+ overload and ROS generation in spinal motor neurons in vitro
SG Carriedo et al.
JOURNAL OF NEUROSCIENCE (2000)
分享论文
