Impact of amino acids on microglial activation and CNS remyelination

Amino acids and their derivatives function as building blocks as well as signaling molecules to modulate various cellular pro-cesses in living organisms. In mice, amino acids accumulate in demyelinated lesions and return to basal levels during remyelination. Studies have found that amino acids and their metabolites modulate immune activity in the central nervous system (CNS) and influence oligodendrocyte differentiation and remyelination efficiency. In this review, we discuss current studies on amino acid metabolism in the context of CNS remyelination. By understanding the mechanisms of amino acid signaling and metabolism in demyelinated lesions, we may deepen our understanding of compartmentalized CNS inflammation in demyelinating disease like multiple sclerosis (MS) and provide evidence to develop novel pharmacological therapies targeting amino acid metabolism to prevent disease worsening.

Automated summary

Amino acids play a crucial role in demyelination and remyelination processes by modulating immune activity in the CNS and influencing oligodendrocyte function. Studying amino acid metabolism can enhance our understanding of CNS inflammation and diseases like multiple sclerosis.