Oncogenic viruses, cancer biology, and innate immunity

Article Oncology

Dendritic cell therapy with CD137L-DC-EBV-VAX in locally recurrent or metastatic nasopharyngeal carcinoma is safe and confers clinical benefit

Emily Nickles et al.

Summary: The study demonstrates the safety and efficacy of CD137L-DC-EBV-VAX in inducing an immune response against EBV-associated nasopharyngeal carcinoma, leading to tumor regression or prevention of progression.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2022)

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Editorial Material Pharmacology & Pharmacy

Longitudinal Analysis Suggests Epstein--Barr as Cause of Multiple Sclerosis

[Anonymous]

CLINICAL PHARMACOLOGY & THERAPEUTICS (2022)

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Review Gastroenterology & Hepatology

Risk of hepatocellular carcinoma after hepatitis C virus cure

Maria Alejandra Luna-Cuadros et al.

Summary: Hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma (HCC) and the introduction of direct-acting antivirals has revolutionized HCV therapy. Successful treatment greatly reduces the risk of HCC, but certain patients, especially those with cirrhosis, remain at risk even after achieving sustained virologic response (SVR). Noninvasive modalities and various fibrosis scores may be used to monitor hepatic fibrosis and predict the risk of HCC in patients with SVR, but further validation and standardization are needed before implementing them in routine clinical care.

WORLD JOURNAL OF GASTROENTEROLOGY (2022)

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Article Multidisciplinary Sciences

Apoptotic caspases suppress an MDA5-driven IFN response during productive replication of human papillomavirus type 31

Ning Huang et al.

Summary: This study reveals a mechanism by which HPV reprograms the cellular environment of differentiating cells by hijacking the function of apoptotic caspases to suppress the interferon (IFN) response. The research demonstrates that caspase inhibition leads to the secretion of IFNs, which can induce the expression of interferon-stimulated genes (ISGs) and block HPV replication. Additionally, the study identifies a role for MDA5 and MAVS in restricting viral replication during the normal HPV life cycle.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Virology

Enhanced host immune responses in presence of HCV facilitate HBV clearance in coinfection

Shuhui Liu et al.

Summary: HBV/HCV coinfection is associated with more severe forms of liver diseases, and HCV significantly inhibits HBV replication. Pathological alteration and upregulation of HBV-specific immune responses were observed in coinfection.

VIROLOGICA SINICA (2022)

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Article Multidisciplinary Sciences

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

Kjetil Bjornevik et al.

Summary: This study suggests that multiple sclerosis may be caused by Epstein-Barr virus, with no direct association with other viral infections. These findings provide clues to the primary cause of MS.

SCIENCE (2022)

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Article

Trends of the Global Hepatitis C Disease Burden: Strategies to Achieve Elimination

Nathalie Brunner et al.

Journal of Preventive Medicine and Public Health (2021)

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Article Immunology

Hepatitis B Vaccines

Jade Pattyn et al.

Summary: The coverage of hepatitis B vaccines is increasing, and the effective implementation of vaccination programs has significantly reduced the morbidity and mortality related to hepatitis B.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Virology

Single-Cell RNAseq Profiling of Human γδ T Lymphocytes in Virus-Related Cancers and COVID-19 Disease

Juan Pablo Cerapio et al.

Summary: The study characterized the differentiation of human gamma delta T lymphocytes in tumors and COVID-19 patients at the single-cell transcriptomic level. It found that tumor-infiltrating gamma delta T cells in certain cancer patients were more likely to recirculate and avoid exhaustion, while in COVID-19 patients, gamma delta T cells relocated to infected lung tissue displaying different differentiation, tissue residency, and exhaustion patterns.

VIRUSES-BASEL (2021)

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Article Virology

Merkel Cell Polyomavirus Infection Induces an Antiviral Innate Immune Response in Human Dermal Fibroblasts

Nathan A. Krump et al.

Summary: MCPyV, which can cause Merkel cell carcinoma, infects most humans asymptomatically. Understanding MCPyV biology and its interaction with host immune response may help develop targeted therapies for MCC. MCPyV replication induces an innate immune response, involving cGAS-STING, NF-kappa B, and IFI16 pathways.

JOURNAL OF VIROLOGY (2021)

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Review Biochemistry & Molecular Biology

HTLV-1 Infection and Pathogenesis: New Insights from Cellular and Animal Models

Greta Forlani et al.

Summary: Cellular and animal models play important roles in studying HTLV-1-associated diseases; cell models can be used to study the mechanisms of HTLV proteins, while animal models can be used to recapitulate pathological processes and validate the effectiveness of treatment methods.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Gastroenterology & Hepatology

Nuclear Sensor Interferon-Inducible Protein 16 Inhibits the Function of Hepatitis B Virus Covalently Closed Circular DNA by Integrating Innate Immune Activation and Epigenetic Suppression

Yuanyuan Yang et al.

HEPATOLOGY (2020)

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Review Obstetrics & Gynecology

Human papillomavirus and cervical cancer

Kehinde Sharafadeen Okunade

JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2020)

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Article Oncology

Intratumoral Delivery of Plasmid IL12 Via Electroporation Leads to Regression of Injected and Noninjected Tumors in Merkel Cell Carcinoma

Shailender Bhatia et al.

CLINICAL CANCER RESEARCH (2020)

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Article Virology

Human Papillomavirus E7 Oncoprotein Subverts Host Innate Immunity via SUV39H1-Mediated Epigenetic Silencing of Immune Sensor Genes

Irene Lo Cigno et al.

JOURNAL OF VIROLOGY (2020)

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Article Virology

Human Papillomavirus 16 E5 Inhibits Interferon Signaling and Supports Episomal Viral Maintenance

Matthew L. Scott et al.

JOURNAL OF VIROLOGY (2020)

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Article Medicine, Research & Experimental

HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING

Xiaobo Luo et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Gastroenterology & Hepatology

Interferon-inducible MX2 is a host restriction factor of hepatitis B virus replication

Yong-Xiang Wang et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Hematology

Tocilizumab in patients with symptomatic Kaposi sarcoma herpesvirus-associated multicentric Castleman disease

Ramya Ramaswami et al.

BLOOD (2020)

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Article Oncology

Study of Toll-like Receptor 3 Gene Polymorphism as a Novel Risk Factor for HCV-related Hepatocellular Carcinoma in Egypt

Shimaa El-Sharawy et al.

CURRENT CANCER DRUG TARGETS (2020)

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Article Medicine, Research & Experimental

Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection

Xiaoming Cheng et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Virology

Arsenic trioxide (As2O3) as a maintenance therapy for adult T cell leukemia/lymphoma

Ambroise Marcais et al.

RETROVIROLOGY (2020)

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Review Microbiology

HTLV-1 in Ophthalmology

Koju Kamoi

FRONTIERS IN MICROBIOLOGY (2020)

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Article Oncology

Elevated IL18 levels in Nasopharyngeal carcinoma induced PD-1 expression on NK cells in TILS leading to poor prognosis

Anthony Kian-Fong Liou et al.

ORAL ONCOLOGY (2020)

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Article Microbiology

PPP6C Negatively Regulates STING-Dependent Innate Immune Responses

Guoxin Ni et al.

MBIO (2020)

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Article Multidisciplinary Sciences

Tumor-associated macrophages in classical Hodgkin lymphoma: hormetic relationship to outcome

Laura Werner et al.

SCIENTIFIC REPORTS (2020)

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Article Immunology

Epstein-Barr Virus Early Protein BFRF1 Suppresses IFN-β Activity by Inhibiting the Activation of IRF3

Ping Wang et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

PPM1G restricts innate immune signaling mediated by STING and MAVS and is hijacked by KSHV for immune evasion

Kuai Yu et al.

SCIENCE ADVANCES (2020)

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Article Microbiology

Human IFIT proteins inhibit lytic replication of KSHV: A new feed-forward loop in the innate immune system

Dajiang Li et al.

PLOS PATHOGENS (2019)

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Article Cell Biology

Chronic Hepatitis C Virus Infection Impairs M1 Macrophage Differentiation and Contributes to CD8+ T-Cell Dysfunction

Faria Ahmed et al.

CELLS (2019)

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Article Gastroenterology & Hepatology

Hepatitis B virus-induced modulation of liver macrophage function promotes hepatocyte infection

Suzanne Faure-Dupuy et al.

JOURNAL OF HEPATOLOGY (2019)

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Article Cell Biology

Phenotypic and functional changes in gamma delta T lymphocytes from HTLV-1 carriers

Raquel Cavalcanti De Albuquerque et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

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Article Virology

Suppression of Stromal Interferon Signaling by Human Papillomavirus 16

Gaurav Raikhy et al.

JOURNAL OF VIROLOGY (2019)

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Review Biochemistry & Molecular Biology

Macrophages and hepatocellular carcinoma

Zhiqiang Tian et al.

CELL AND BIOSCIENCE (2019)

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Article Oncology

Combining Immune Checkpoint Blockade and Tumor-Specific Vaccine for Patients With Incurable Human Papillomavirus 16-Related Cancer A Phase 2 Clinical Trial

Erminia Massarelli et al.

JAMA ONCOLOGY (2019)

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Article Biology

IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP

Arunava Roy et al.

ELIFE (2019)

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Review Cell Biology

Mechanisms Underlying Hepatitis C Virus-Associated Hepatic Fibrosis

Mousumi Khatun et al.

CELLS (2019)

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Article Gastroenterology & Hepatology

Impact of direct-acting antivirals on early recurrence of HCV-related HCC: Comparison with interferon-based therapy

Mizuki Nishibatake Kinoshita et al.

JOURNAL OF HEPATOLOGY (2019)

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Article Virology

Human MxB Inhibits the Replication of Hepatitis C Virus

Dong-Rong Yi et al.

JOURNAL OF VIROLOGY (2019)

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Article Oncology

Intratumoral G100, a TLR4 Agonist, Induces Antitumor Immune Responses and Tumor Regression in Patients with Merkel Cell Carcinoma

Shailender Bhatia et al.

CLINICAL CANCER RESEARCH (2019)

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Article Biochemistry & Molecular Biology

IFI16 regulates HTLV-1 replication through promoting HTLV-1 RTI-induced innate immune responses

Bo Yang et al.

FEBS LETTERS (2018)

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Article Gastroenterology & Hepatology

HBV Bypasses the Innate Immune Response and Does Not Protect HCV From Antiviral Activity of Interferon

Pascal Mutz et al.

GASTROENTEROLOGY (2018)

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Article Dermatology

MCV-miR-M1 Targets the Host-Cell Immune Response Resulting in the Attenuation of Neutrophil Chemotaxis

Pouria Akhbari et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

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Article Dermatology

Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics

Kelly G. Paulson et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2018)

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Article Virology

Caspase-Dependent Suppression of Type I Interferon Signaling Promotes Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication

Tate Tabtieng et al.

JOURNAL OF VIROLOGY (2018)

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Article Microbiology

RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner

Yugen Zhang et al.

MBIO (2018)

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Article Multidisciplinary Sciences

Polymorphisms in the Toll-like receptor 3 (TLR3) gene are associated with the natural course of hepatitis B virus infection in Caucasian population

Janett Fischer et al.

SCIENTIFIC REPORTS (2018)

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Article Microbiology

Human papillomavirus type 16 antagonizes IRF6 regulation of IL-1β

Michelle Ainouze et al.

PLOS PATHOGENS (2018)

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Article Multidisciplinary Sciences

RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection

Yang Zhao et al.

NATURE COMMUNICATIONS (2018)

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Review Gastroenterology & Hepatology

Hepatitis B virus reactivation during direct-acting antiviral therapy for hepatitis C: a systematic review and meta-analysis

Marcus M. Muecke et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2018)

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Article Immunology

Ku70 Senses HTLV-1 DNA and Modulates HTLV-1 Replication

Jie Wang et al.

JOURNAL OF IMMUNOLOGY (2017)

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Article Immunology

EBV MicroRNA BART16 Suppresses Type I IFN Signaling

Marjolein J. G. Hooykaas et al.

JOURNAL OF IMMUNOLOGY (2017)

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Article Immunology

Epstein-Barr Virus miR-BART6-3p Inhibits the RIG-I Pathway

Yuanjun Lu et al.

JOURNAL OF INNATE IMMUNITY (2017)

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Article Virology

Interferon-γ-inducible protein 16 (IFI16) is required for the maintenance of Epstein-Barr virus latency

Gina Pisano et al.

VIROLOGY JOURNAL (2017)

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Article Immunology

The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus

Seiichi Sato et al.

IMMUNITY (2015)

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Article Gastroenterology & Hepatology

MDA5 plays a critical role in interferon response during hepatitis C virus infection

Xuezhi Cao et al.

JOURNAL OF HEPATOLOGY (2015)

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Article Virology

An Important Role for Mitochondrial Antiviral Signaling Protein in the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle

John A. West et al.

JOURNAL OF VIROLOGY (2014)

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Article Oncology

Siltuximab for multicentric Castleman's disease: a randomised, double-blind, placebo-controlled trial

Frits van Rhee et al.

LANCET ONCOLOGY (2014)

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Article Immunology

Melanoma Differentiation-Associated Gene 5 Senses Hepatitis B Virus and Activates Innate Immune Signaling To Suppress Virus Replication

Hsin-Lin Lu et al.

JOURNAL OF IMMUNOLOGY (2013)

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Article Multidisciplinary Sciences

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

Takeshi Saito et al.

NATURE (2008)

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Article Genetics & Heredity

A novel primary immunodeficiency with specific natural-killer cell deficiency maps to the centromeric region of chromosome 8

C Eidenschenk et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2006)

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Review Microbiology

Hepatitis B virus biology

C Seeger et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2000)

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Oncogenic viruses, cancer biology, and innate immunity

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