期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 70, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2022.102177
关键词
Cell signaling; Inositol phosphate; Inositol pyrophosphate; IP6K; PPIP5K; 5PP-InsP(5); InsP(8); Protein ligand interaction; SPX domain; Chemical tools; Protein pyrophosphorylation
资金
- Deutsche Forschungsgesellschaft [EXC 2008-390540038]
Researchers summarize the recent mechanistic insights into PP-InsP signaling, illustrating the progress in connecting mechanism and function of PP-InsPs.
Inositol pyrophosphates (PP-InsPs) constitute a group of highly charged messengers, which regulate central biological processes in health and disease, such as cellular phosphate and general energy homeostasis. Deciphering the molecular mechanisms underlying PP-InsP-mediated signaling remains a challenge due to the unique properties of these molecules, the different modes of action they can access, and a somewhat limited chemical and analytical toolset. Herein, we summarize the most recent mechanistic insights into PP-InsP signaling, which illustrate our progress in connecting mechanism and function of PP-InsPs.
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