期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 70, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2022.102178
关键词
Synthetic biology; Microbiota; Human gut commensal bacteria; Bacteroides; Genetic circuits
资金
- National Science Foundation [NSF-CCF-1521925]
- National Institutes of Health [NIH-5-U01-CA2550554-02, NIH-50000655-5500001351]
Recent progress in synthetic biology has opened up possibilities for engineering microbiomes. This review focuses on expanding the genetic toolkit for Bacteroides thetaiotaomicron and its potential applications in microbiome engineering. The authors also provide their perspective on the challenges and future opportunities for using gut-associated bacteria as living therapeutic agents.
The role of the microbiome in health and disease is attracting the attention of researchers seeking to engineer microorganisms for diagnostic and therapeutic applications. Recent progress in synthetic biology may enable the dissection of host-microbiota interactions. Sophisticated genetic circuits that can sense, compute, memorize, and respond to signals have been developed for the stable commensal bacterium Bacteroides thetaiotaomicron, dominant in the human gut. In this review, we highlight recent advances in expanding the genetic toolkit for B. thetaiotaomicron and foresee several applications of this species for microbiome engineering. We provide our perspective on the challenges and future opportunities for the engineering of human gut-associated bacteria as living therapeutic agents.
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