Ibogaine/Noribogaine in the Treatment of Substance Use Disorders: A Systematic Review of the Current Literature

Review Chemistry, Medicinal

Psychedelics and Hallucinogens in Psychiatry: Finding New Pharmacological Targets

Teresa Reynolds Sousa et al.

Summary: Psychedelics and hallucinogens may contribute to the discovery of new drugs for treating certain psychiatric disorders. Evidence suggests their potential use in depression and anxiety disorders.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2022)

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Article Substance Abuse

Safety of ibogaine administration in detoxification of opioid-dependent individuals: a descriptive open-label observational study

Thomas Knuijver et al.

Summary: This study found that ibogaine treatment for patients with opioid use disorder can induce clinically relevant but reversible QTc prolongation, bradycardia, and severe ataxia. However, no Torsades de Pointes were observed, and most patients tolerated withdrawal and psychomimetic effects well.

ADDICTION (2022)

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Review Neurosciences

Assessing the risk-benefit profile of classical psychedelics: a clinical review of second-wave psychedelic research

David Bender et al.

Summary: A reassessment of the potential benefits of psychedelic drugs has led to major clinical trials and legislative efforts. Recent studies support the hypothesis that psychedelic-assisted psychotherapy can alleviate symptoms of psychiatric conditions without serious adverse events. However, limitations in study design need to be addressed.

PSYCHOPHARMACOLOGY (2022)

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Review Clinical Neurology

Effects of ayahuasca and its alkaloids on substance use disorders: an updated (2016-2020) systematic review of preclinical and human studies

Lucas Silva Rodrigues et al.

Summary: The study found that ayahuasca and its alkaloids have therapeutic effects in the treatment of SUDs. Further randomized controlled trials are needed to confirm these results and there is a lack of standardization on ayahuasca doses.

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2022)

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Review Clinical Neurology

Psilocybin-assisted psychotherapy for depression: Emerging research on a psychedelic compound with a rich history

Craig Pearson et al.

Summary: There is a need for novel therapies for individuals with depression, and the use of psilocybin combined with supportive psychotherapy has shown rapid and sustained antidepressant effects. This review provides a comprehensive look at the potential use of psilocybin in the treatment of depression and discusses current research, limitations, and barriers. The results are contextualized within the current treatment landscape and the clinical needs these therapies may fulfill.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2022)

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Article Clinical Neurology

Substance-related exogenous psychosis: a postmodern syndrome

Giovanni Martinotti et al.

Summary: The article focuses on the association between substance use and psychosis, proposing the establishment of a new diagnostic framework to differentiate between different types of psychotic disorders. It suggests that Substance-Related Exogenous Psychosis (SREP) has distinct clinical characteristics from schizophrenia, necessitating further research and evidence to support this new diagnostic category.

CNS SPECTRUMS (2021)

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Article Medicine, Legal

Death due to consumption of ibogaine: case report

Tijana Acimovic et al.

Summary: Ibogaine is a psychotropic substance extracted from the roots of a plant, known for its euphoric and hallucinogenic effects. Widely used in addiction treatment, it can have serious side effects and even result in death when taken in large doses.

FORENSIC SCIENCE MEDICINE AND PATHOLOGY (2021)

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Article Multidisciplinary Sciences

A non-hallucinogenic psychedelic analogue with therapeutic potential

Lindsay P. Cameron et al.

Summary: The study identifies key structural elements of the potential therapeutic pharmacophore of ibogaine and designs tabernanthalog, a safer, non-hallucinogenic analogue of ibogaine. Tabernanthalog is found to promote neural plasticity, reduce addiction-related behavior, and produce antidepressant effects in rodents. Through careful chemical design, it is possible to modify psychedelic compounds to produce safer, non-hallucinogenic variants with therapeutic potential.

NATURE (2021)

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Review Psychiatry

Clinical and biological predictors of psychedelic response in the treatment of psychiatric and addictive disorders: A systematic review

Bruno Romeo et al.

Summary: The intensity of the acute psychedelic experience was found to be the main predicting factor of response in all psychiatric and addictive disorders studied, suggesting a potential mechanism involving modulation of the serotoninergic system, default mode network (DMN) disintegration and re-integration, or anti-inflammatory effects.

JOURNAL OF PSYCHIATRIC RESEARCH (2021)

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Review Neurosciences

New psychoactive substances (NPS) and serotonin syndrome onset: A systematic review

Fabrizio Schifano et al.

Summary: The use of several new psychoactive substances (NPS) has become popular, posing global health risks. This systematic review investigated the association between Serotonin Syndrome (SS) and NPS intake, finding that various NPS can lead to SS, including psychedelic phenethylamines and synthetic cathinones. Most substances were ingested orally, but other routes were reported. A majority of subjects had no psychiatric history.

EXPERIMENTAL NEUROLOGY (2021)

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Review Medicine, General & Internal

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

Matthew J. Page et al.

Summary: The PRISMA statement was designed to help systematic reviewers transparently report the purpose, methods, and findings of their reviews. The updated PRISMA 2020 statement includes new reporting guidance, a 27-item checklist, an abstract checklist, and revised flow diagrams for reviews.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Editorial Material Biochemistry & Molecular Biology

Evaluating the toxicity and therapeutic potential of ibogaine in the treatment of chronic opioid abuse

Matthias Luz et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2021)

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Review Neurosciences

Therapeutic Potentials of Ketamine and Esketamine in Obsessive-Compulsive Disorder (OCD), Substance Use Disorders (SUD) and Eating Disorders (ED): A Review of the Current Literature

Giovanni Martinotti et al.

Summary: The obsessive-compulsive spectrum encompasses disorders with similar core features, such as obsessive thoughts, compulsive behaviors, and anxiety. Ketamine has shown remarkable results in treating depression, PTSD, and OCD, but its efficacy in SUD and ED remains uncertain. Further studies are needed to clarify its potential in these conditions.

BRAIN SCIENCES (2021)

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Article Clinical Neurology

Exploratory Controlled Study of the Migraine-Suppressing Effects of Psilocybin

Emmanuelle A. D. Schindler et al.

Summary: An exploratory study found that a single administration of psilocybin had a lasting therapeutic effect on migraine headaches, separate from its acute psychotropic effects. This highlights the importance of further investigating the clinical effects of select 5-HT2A receptor compounds in migraine and other neuropsychiatric conditions.

NEUROTHERAPEUTICS (2021)

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Review Neurosciences

The Negative Affect of Protracted Opioid Abstinence: Progress and Perspectives From Rodent Models

Lola Welsch et al.

BIOLOGICAL PSYCHIATRY (2020)

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Review Anesthesiology

Chronic pain and psychedelics: a review and proposed mechanism of action

Joel P. Castellanos et al.

REGIONAL ANESTHESIA AND PAIN MEDICINE (2020)

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Article Psychiatry

An analytical study of iboga alkaloids contained in Tabernanthe iboga-derived products offered by ibogaine treatment providers

Jose Carlos Bouso et al.

ARCHIVES OF CLINICAL PSYCHIATRY (2020)

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Article Substance Abuse

Ibogaine therapy for addiction: Consumer views from online fora

Michaela Barber et al.

INTERNATIONAL JOURNAL OF DRUG POLICY (2020)

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Article Pharmacology & Pharmacy

Novel treatment of opioid use disorder using ibogaine and iboga in two adults

Claire Wilson et al.

JOURNAL OF PSYCHEDELIC STUDIES (2020)

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Article Pharmacology & Pharmacy

Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits

Soledad Marton et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Medicine, General & Internal

RoB 2: a revised tool for assessing risk of bias in randomised trials

Jonathan A. C. Sterne et al.

BMJ-BRITISH MEDICAL JOURNAL (2019)

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Article Emergency Medicine

IBOGAINE CONSUMPTION WITH SEIZURE-LIKE EPISODES, QTC-PROLONGATION, AND CAPTURED CARDIAC DYSRHYTHMIAS

James Grogan et al.

JOURNAL OF EMERGENCY MEDICINE (2019)

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Article Psychology, Clinical

Ibogaine and Subjective Experience: Transformative States and Psychopharmacotherapy in the Treatment of Opioid Use Disorder

Thomas K. Brown et al.

JOURNAL OF PSYCHOACTIVE DRUGS (2019)

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Editorial Material Psychology, Clinical

Breaking the cycle of opioid use disorder with Ibogaine

Deborah C. Mash

AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE (2018)

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Article Psychology, Clinical

Ibogaine treatment outcomes for opioid dependence from a twelve-month follow-up observational study

Geoffrey E. Noller et al.

AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE (2018)

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Article Psychology, Clinical

Treatment of opioid use disorder with ibogaine: detoxification and drug use outcomes

Thomas Kingsley Brown et al.

AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE (2018)

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Letter Pharmacology & Pharmacy

Hallucinogen Persisting Perception Disorder After Ibogaine Treatment for Opioid Dependence

Thomas Knuijver et al.

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2018)

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Review Neurosciences

Hallucinogen Persisting Perception Disorder: Etiology, Clinical Features, and Therapeutic Perspectives

Giovanni Martinotti et al.

BRAIN SCIENCES (2018)

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Article Cardiac & Cardiovascular Systems

Cardiac arrest after ibogaine intoxication

Christian Steinberg et al.

JOURNAL OF ARRHYTHMIA (2018)

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Article Psychology, Clinical

Changes in Withdrawal and Craving Scores in Participants Undergoing Opioid Detoxification Utilizing Ibogaine

Benjamin J. Malcolm et al.

JOURNAL OF PSYCHOACTIVE DRUGS (2018)

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Article Anthropology

Understanding the Healing Potential of Ibogaine through a Comparative and Interpretive Phenomenology of the Visionary Experience

James Rodger

ANTHROPOLOGY OF CONSCIOUSNESS (2018)

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Article Psychology, Clinical

A Mixed-Method Analysis of Persisting Effects Associated with Positive Outcomes Following Ibogaine Detoxification

Alan K. Davis et al.

JOURNAL OF PSYCHOACTIVE DRUGS (2018)

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Article Psychology, Clinical

Examination of the Phenomenology of the Ibogaine Treatment Experience: Role of Altered States of Consciousness and Psychedelic Experiences

Annamarie Heink et al.

JOURNAL OF PSYCHOACTIVE DRUGS (2017)

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Review Toxicology

How toxic is ibogaine?

Ruud P. W. Litjens et al.

CLINICAL TOXICOLOGY (2016)

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Article Emergency Medicine

A CASE OF QT PROLONGATION AND TORSADES DE POINTES CAUSED BY IBOGAINE TOXICITY

Catherine Hildyard et al.

JOURNAL OF EMERGENCY MEDICINE (2016)

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Review Psychiatry

Ibogaine and addiction in the animal model, a systematic review and meta-analysis

M. Belgers et al.

TRANSLATIONAL PSYCHIATRY (2016)

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Review Pharmacology & Pharmacy

Ibogaine-associated cardiac arrest and death: case report and review of the literature

Jessica A. Meisner et al.

THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY (2016)

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Article Pharmacology & Pharmacy

Ascending Single-Dose, Double-Blind, Placebo-Controlled Safety Study of Noribogaine in Opioid-Dependent Patients

Paul Glue et al.

CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT (2016)

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Article Psychology, Clinical

Remission of Severe Opioid Use Disorder with Ibogaine: A Case Report

Laurie Cloutier-Gill et al.

JOURNAL OF PSYCHOACTIVE DRUGS (2016)

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Article Emergency Medicine

Internet-purchased ibogaine toxicity confirmed with serum, urine, and product content levels

Charles W. O'Connell et al.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2015)

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Review Biochemistry & Molecular Biology

The Anti-Addiction Drug Ibogaine and the Heart: A Delicate Relation

Xaver Koenig et al.

MOLECULES (2015)

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Article Neurosciences

Noribogaine is a G-protein biased κ-opioid receptor agonist

Emeline L. Maillet et al.

NEUROPHARMACOLOGY (2015)

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Article Pharmacology & Pharmacy

Ascending-Dose Study of Noribogaine in Healthy Volunteers: Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability

Paul Glue et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2015)

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Article Substance Abuse

Mania Following Use of Ibogaine: A Case Series

Cole J. Marta et al.

AMERICAN JOURNAL ON ADDICTIONS (2015)

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Article Clinical Neurology

Treating drug dependence with the aid of ibogaine: A retrospective study

Eduardo Ekman Schenberg et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2014)

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Article Pharmacology & Pharmacy

Mechanism of hERG Channel Block by the Psychoactive Indole Alkaloid Ibogaine

Patrick Thurner et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2014)

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Letter Cardiac & Cardiovascular Systems

Using risk difference as opposed to odds-ratio in meta-analysis

Andrea Messori et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2013)

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Article Medicine, Legal

Fatal Case of a 27-Year-Old Male After Taking Iboga in Withdrawal Treatment: GC-MS/MS Determination of Ibogaine and Ibogamine in Iboga Roots and Postmortem Biological Material

Cedric Mazoyer et al.

JOURNAL OF FORENSIC SCIENCES (2013)

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Article Multidisciplinary Sciences

Effect of Iboga Alkaloids on μ-Opioid Receptor-Coupled G Protein Activation

Tamara Antonio et al.

PLOS ONE (2013)

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Review Medicine, Legal

Ibogaine related sudden death: A case report

Stavroula A. Papadodima et al.

JOURNAL OF FORENSIC AND LEGAL MEDICINE (2013)

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Letter Toxicology

Ibogaine-associated ventricular tachyarrhythmias

Ales Pleskovic et al.

CLINICAL TOXICOLOGY (2012)

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Review Medicine, Legal

Fatalities Temporally Associated with the Ingestion of Ibogaine

Kenneth R. Alper et al.

JOURNAL OF FORENSIC SCIENCES (2012)

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Review Pharmacology & Pharmacy

Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders

Anita E. Autry et al.

PHARMACOLOGICAL REVIEWS (2012)

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Article Pharmacology & Pharmacy

The anti-addictive drug ibogaine modulates voltage-gated ion channels and may trigger cardiac arrhythmias

Michael Kovar et al.

BMC Pharmacology & Toxicology (2011)

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Article Substance Abuse

Ibogaine therapy in the treatment of opiate dependency

Peter Brackenridge

DRUGS AND ALCOHOL TODAY (2010)

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Review Plant Sciences

The ibogaine medical subculture

Kenneth R. Alper et al.

JOURNAL OF ETHNOPHARMACOLOGY (2008)

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Article Biochemistry & Molecular Biology

Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter

Miriam T. Jacobs et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

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Article Biochemistry & Molecular Biology

Autoregulation of glial cell line-derived neurotrophic factor expression: implications for the long-lasting actions of the anti-addiction drug, Ibogaine

Dao-Yao He et al.

FASEB JOURNAL (2006)

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Article Neurosciences

Modulation of NMDA receptors in the cerebellum. 1. Properties of the NMDA receptor that modulate its function

M Llansola et al.

CEREBELLUM (2005)

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Article Neurosciences

Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumption

DY He et al.

JOURNAL OF NEUROSCIENCE (2005)

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Review Pharmacology & Pharmacy

Hallucinogens

DE Nichols

PHARMACOLOGY & THERAPEUTICS (2004)

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Article Pharmacology & Pharmacy

Antagonism of alpha 3 beta 4 nicotinic receptors as a strategy to reduce opioid and stimulant self-administration

SD Glick et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2002)

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Article Health Care Sciences & Services

Choice of effect measure for epidemiological data

SD Walter

JOURNAL OF CLINICAL EPIDEMIOLOGY (2000)

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Ibogaine/Noribogaine in the Treatment of Substance Use Disorders: A Systematic Review of the Current Literature

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