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Limbic-Predominant Age-Related TDP-43 Encephalopathy: LATE-Breaking Updates in Clinicopathologic Features and Biomarkers

期刊

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
卷 22, 期 11, 页码 689-698

出版社

SPRINGER
DOI: 10.1007/s11910-022-01232-4

关键词

Limbic-predominant age-related TDP-43 encephalopathy (LATE); TAR DNA-binding protein 43 (TDP-43); Alzheimer's disease (AD); Magnetic resonance imaging (MRI); Positron emission tomography (PET); Biomarkers

资金

  1. Ruth L. Kirschstein National Research Service Award [NIA F30 AG074524]
  2. University of Pennsylvania Alzheimer's Disease Core Center [NIA P30 AG072979]

向作者/读者索取更多资源

Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a neurodegenerative disease that is distinct from other cognitive disorders and commonly coexists with Alzheimer's disease and cerebrovascular disease. Researchers are developing novel biomarkers to diagnose LATE.
Purpose of Review Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a recently defined neurodegenerative disease characterized by amnestic phenotype and pathological inclusions of TAR DNA-binding protein 43 (TDP-43). LATE is distinct from rarer forms of TDP-43 diseases such as frontotemporal lobar degeneration with TDP-43 but is also a common copathology with Alzheimer's disease (AD) and cerebrovascular disease and accelerates cognitive decline. LATE contributes to clinicopathologic heterogeneity in neurodegenerative diseases, so it is imperative to distinguish LATE from other etiologies. Recent Findings Novel biomarkers for LATE are being developed with magnetic resonance imaging (MRI) and positron emission tomography (PET). When cooccurring with AD, LATE exhibits identifiable patterns of limbic-predominant atrophy on MRI and hypometabolism on F-18-fluorodeoxyglucose PET that are greater than expected relative to levels of local AD pathology. Efforts are being made to develop TDP-43-specific radiotracers, molecularly specific biofluid measures, and genomic predictors of TDP-43. LATE is a highly prevalent neurodegenerative disease distinct from previously characterized cognitive disorders.

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