Biologically Active 2-Oxazolidinone Derivatives Beyond Antibacterial Activities

2-Oxazolidinone is well known as a pharmacophore for antibacterial agents represented by two marketed medicines, Linezolid and Tedizolid. On the other hand, there are growing reports on the various biological activities of 2-oxazolidinones beyond antibacterial activities. Therefore, in this review, we provide an overview of the progress of this untraditional area of 2-oxazolidinones in the past 10 years (2011-2021).

Automated summary

2-Oxazolidinone is commonly used as a pharmacophore for antibacterial agents, such as Linezolid and Tedizolid. However, recent research has revealed various biological activities of 2-oxazolidinones beyond their antibacterial properties. In this review, we provide an overview of the progress in this unconventional area of 2-oxazolidinones over the past 10 years (2011-2021).