4.6 Review

Recent Advances: From Cell Biology to Cell Therapy in Atherosclerosis Plaque via Stent Implantation

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Article Biochemistry & Molecular Biology

NRP2 promotes atherosclerosis by upregulating PARP1 expression and enhancing low shear stress-induced endothelial cell apoptosis

Shuai Luo et al.

Summary: This study elucidates the regulatory mechanism of NRP2 in atheroprone phenotype of endothelial cells under low shear stress and identifies NRP2 as a promising therapeutic target for the treatment of atherosclerotic disorders.

FASEB JOURNAL (2022)

Review Biochemistry & Molecular Biology

A novel therapeutic strategy for atherosclerosis: autophagy-dependent cholesterol efflux

Haipeng Guo et al.

Summary: Atherosclerosis is a chronic inflammatory disease characterized by abnormal lipid metabolism. Cholesterol efflux, regulated by autophagy, serves as an effective mechanism to prevent the occurrence of atherosclerosis. Various targeted molecules can induce autophagy and promote the expression of cholesterol transporters, providing new treatment approaches for atherosclerosis.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2022)

Article Cell & Tissue Engineering

Heparin Immobilization of Tissue Engineered Xenogeneic Small Diameter Arterial Scaffold Improve Endothelialization

Kishor Tardalkar et al.

Summary: This study proposed a method of inducing graft remodeling through heparin coating in small-diameter decellularized arterial grafts, showing anti-thrombogenicity and endothelialization. Mechanical testing indicated no significant differences in strain characteristics and modulus among native tissues, decellularized scaffolds, and transplanted scaffolds. These findings suggest that heparin-immobilized ECM coating offers a functionalized biomaterial for developing small-diameter vascular grafts.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2022)

Review Cell Biology

Protective Effects of Curcumin in Cardiovascular Diseases-Impact on Oxidative Stress and Mitochondria

Fiona Frederike Cox et al.

Summary: Cardiovascular diseases (CVDs) are a major cause of global mortality. Aging and obesity, which are also global problems, are major risk factors for CVDs. Both aging and obesity are associated with oxidative stress, mitochondrial dysfunction, metabolic abnormalities, and inflammation. Curcumin, a plant substance found in turmeric root, has shown promise in attenuating multiple risk factors for CVDs in aging and obesity. However, more clinical trials are needed to fully understand its potential.
Review Cell Biology

The Function, Regulation and Mechanism of Programmed Cell Death of Macrophages in Atherosclerosis

Chang Liu et al.

Summary: Atherosclerosis is a chronic inflammatory vascular disease, and macrophages play a significant role in its progression. Recent studies have highlighted the critical role of programmed cell death in macrophages in the development of vulnerable plaques in atherosclerosis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Article Chemistry, Multidisciplinary

Nanoconfined anti-oxidizing RAFT nitroxide radical polymer for reduction of low-density lipoprotein oxidation and foam cell formation

Suman Basak et al.

Summary: Atherosclerosis, a leading cause of death worldwide, can be effectively treated using newly developed ROS-scavenging antioxidant nanoparticles. These nanoparticles, synthesized via reversible addition-fragmentation chain-transfer (RAFT) polymerization, act as a superoxide dismutase (SOD) mimetic agent. The nanoparticles are shown to be taken up by macrophages and exhibit cytocompatibility. Additionally, the nanoparticles have been demonstrated to inhibit foam cell formation in macrophages.

NANOSCALE ADVANCES (2022)

Review Peripheral Vascular Disease

Pitavastatin: Coronary Atherosclerotic Plaques Changes and Cardiovascular Prevention

Francesco Fici et al.

Summary: Stains are the preferred therapeutic approach for controlling lipid levels and cardiovascular risk. Pitavastatin, a new-generation statin, has shown significant efficacy in reducing adverse cardiovascular events and improving plaque morphology in patients with coronary artery disease. Its effectiveness is greater or similar to other statins.

HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION (2022)

Article Biophysics

Improve endothelialization of metallic cardiovascular stent via femtosecond laser induced micro/nanostructure dependent cells proliferation and drug delivery control

Chunyong Liang et al.

Summary: In this study, femtosecond laser surface treatment was used to modify the surface texture of metallic stent, aiming to enhance the performance of drug loaded PLGA coating. The results demonstrated that different surface textures have different effects on the drug loading capacity and release profile. This study also showed the endothelialization potential and restenosis resistance of rapamycin eluting stent.

COLLOIDS AND SURFACES B-BIOINTERFACES (2022)

Article Biotechnology & Applied Microbiology

H2O2-responsive VEGF/NGF gene co-delivery nano-system achieves stable vascularization in ischemic hindlimbs

Youlu Chen et al.

Summary: The research demonstrated that VEGF/NGF-NPs, by co-delivering VEGF and NGF genes, eliminating excessive H2O2, and promoting stable angiogenesis, enhanced the treatment effects of PVD.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Review Immunology

miR-155: An Important Role in Inflammation Response

Jingyan Hu et al.

Summary: This article introduces miRNAs and the important representative miR-155 in the regulation of gene expression and treatment of inflammatory diseases. It reviews the research on miR-155 in recent years, focusing on its functions in different inflammatory cells. This is of great significance for the integration of Chinese and Western medicine in treatment.

JOURNAL OF IMMUNOLOGY RESEARCH (2022)

Article Engineering, Biomedical

Bioactive extracellular matrix scaffolds engineered with proangiogenic proteoglycan mimetics and loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing

Siqi He et al.

Summary: In this study, a multi-functional pro-angiogenic molecule was designed and synthesized to enhance the treatment of diabetic ischemic wounds. The modified extracellular matrix scaffolds significantly promoted cell attachment, growth, and survival, leading to improved wound healing and neovascularization in an ischemic environment.

BIOACTIVE MATERIALS (2022)

Review Cardiac & Cardiovascular Systems

The role of CD36 in cardiovascular disease

Hongyang Shu et al.

Summary: CD36 is a multifunctional receptor widely expressed in various organs, and plays a crucial role in the uptake of fatty acids in myocardial tissue. Its regulation and post-translational modifications are closely associated with the progression of cardiovascular diseases, suggesting it as a potential therapeutic target.

CARDIOVASCULAR RESEARCH (2022)

Article Hematology

Vitronectin stabilizes intravascular adhesion of neutrophils by coordinating β2 integrin clustering

Gabriele Zuchtriegel et al.

Summary: This study revealed a previously unrecognized function of vitronectin in regulating the transition of dynamic to static interactions between neutrophils and microvascular endothelial cells, thereby effectively controlling neutrophil trafficking to inflamed tissue. Targeting the vitronectin-plasminogen activator inhibitor-1 complex could be beneficial for the prevention and treatment of inflammatory pathologies.

HAEMATOLOGICA (2021)

Letter Cardiac & Cardiovascular Systems

Sca1+ Cells Minimally Contribute to Smooth Muscle Cells in Atherosclerosis

Haixiao Wang et al.

CIRCULATION RESEARCH (2021)

Article Polymer Science

A coaxially structured trilayered gallic acid-based antioxidant vascular graft for treating coronary artery disease

Ankita Das et al.

Summary: A novel stent design using biomimetically designed trilayered electrospun materials has been developed to avoid restenosis and promote re-endothelialization of damaged blood vessels. The stent material demonstrated excellent antioxidant potential and hemocompatibility, reducing smooth muscle cell growth on the scaffold.

EUROPEAN POLYMER JOURNAL (2021)

Review Biochemistry & Molecular Biology

Role of Macrophages and RhoA Pathway in Atherosclerosis

Malgorzata Kloc et al.

Summary: The development, progression, or stabilization of atherosclerotic plaques depend on the role of pro-inflammatory and anti-inflammatory macrophages. Targeting macrophages and the RhoA pathway could potentially inhibit inflammation, promote tissue remodeling, and contribute to the resolution of atherosclerosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Anti-VEGF-R2 Aptamer and RGD Peptide Synergize in a Bifunctional Hydrogel for Enhanced Angiogenic Potential

Tanaya Roy et al.

Summary: Hydrogels are of interest for tissue regeneration and wound healing due to their absorbing, swelling properties, and ability to mimic the natural extracellular matrix. Incorporating RGD adhesion peptides and an anti-VEGF-R2 DNA aptamer into a hydrogel can enhance cell attachment, growth, viability, migration, and induce angiogenesis, making it suitable for advanced tissue regeneration applications like wound healing.

MACROMOLECULAR BIOSCIENCE (2021)

Article Medicine, Research & Experimental

Long non-coding RNA AL355711 promotes smooth muscle cell migration through the ABCG1/MMP3 pathway

Chun-Min Kang et al.

Summary: This study found that lncRNA AL355711 promotes VSMC migration and atherosclerosis via the ABCG1/MMP3 pathway. Inhibition of lncRNA AL355711 could serve as a novel therapeutic target for atherosclerosis, and it may be a new biomarker for atherosclerotic CAD.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

Article Biochemistry & Molecular Biology

Cell therapy for the treatment of heart disease: Renovation work on the broken heart is still in progress

Paolo Madeddu

Summary: Cardiovascular cell therapy plays a crucial role in addressing cardiovascular diseases and holds great potential for development. Understanding scientific advancements and emerging technologies can help us better tackle the challenges in this field.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Review Cell Biology

Novel insights: Dynamic foam cells derived from the macrophage in atherosclerosis

Jun Li et al.

Summary: Atherosclerosis is a chronic disease caused by the interaction between disordered lipoproteins and an inappropriate immune response. The formation of foam cells, a key pathological change in the early stage of atherosclerosis, is influenced by multiple factors. The process of foam cell formation involves a dynamic balance among lipid uptake, treatment, and reverse cholesterol transport, influenced by various intracellular organelles and pathways.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Article Cell Biology

CTRP12 ameliorates atherosclerosis by promoting cholesterol efflux and inhibiting inflammatory response via the miR-155-5p/LXRα pathway

Gang Wang et al.

Summary: This study demonstrated that CTRP12 protects against atherosclerosis by enhancing reverse cholesterol transport efficiency and mitigating vascular inflammation through the miR-155-5p/LXRα pathway. Overexpression of CTRP12 reduced atherosclerotic lesion area, increased HDL cholesterol levels, and promoted macrophage polarization. These findings suggest that stimulating CTRP12 production could be a novel approach for reducing atherosclerosis.

CELL DEATH & DISEASE (2021)

Article Cell Biology

STAT6 Signaling Mediates PPARγ Activation and Resolution of Acute Sterile Inflammation in Mice

Ye-J Lee et al.

Summary: In a murine model of zymosan-induced peritonitis, enhanced STAT6 signaling leads to PPAR gamma-mediated macrophage programming, contributing to increased efferocytosis and inflammation resolution. STAT6 deficiency exacerbates proinflammatory responses and impairs resolution of inflammation.
Article Engineering, Biomedical

Significant difference between sirolimus and paclitaxel nanoparticles in anti-proliferation effect in normoxia and hypoxia: The basis of better selection of atherosclerosis treatment

Youlu Chen et al.

Summary: Through experimental exploration of the different mechanisms of action of sirolimus and paclitaxel in the treatment of vascular restenosis, it was found that sirolimus more effectively inhibits the proliferation of endothelial cells and smooth muscle cells under hypoxic conditions by inhibiting HIF-1α expression and glycolysis.

BIOACTIVE MATERIALS (2021)

Article Engineering, Biomedical

A novel mechanism of inhibiting in-stent restenosis with arsenic trioxide drug-eluting stent: Enhancing contractile phenotype of vascular smooth muscle cells via YAP pathway

Yinping Zhao et al.

Summary: The study demonstrates that arsenic trioxide (ATO) inhibits VSMC proliferation, induces phenotypic transition, and regulates the physiological processes of VSMCs by inhibiting Yes-associated protein (YAP) nuclear translocation. The interaction of YAP with the Rho-associated protein kinase (ROCK) pathway through ATO mediates the contractile phenotype of VSMCs. These findings provide insights into the potential clinical therapeutic mechanisms of ATO in drug-eluting stents for in-stent restenosis (ISR).

BIOACTIVE MATERIALS (2021)

Article Nanoscience & Nanotechnology

Endothelial Cell-Mediated Gene Delivery for In Situ Accelerated Endothelialization of a Vascular Graft

Jiaying Zhou et al.

Summary: The intelligent gene delivery small-caliber vascular graft combines EC adhesive peptide and responsive gene delivery system to achieve rapid endothelialization with high transfection efficiency. The gene release system on the graft surface undergoes enzymatic release, while also specifically adhering to ECs and maintaining temporary stability in blood flow due to the GPQGIWGQ-C peptide linker.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Biochemistry & Molecular Biology

LncRNA AC105942.1 Downregulates hnRNPA2/B1 to Attenuate Vascular Smooth Muscle Cells Proliferation

Ru-Yi Zhang et al.

Summary: The study found that lncRNA AC105942.1 inhibits VSMCs proliferation by downregulating hnRNPA2B1, thus providing protection against atherosclerosis. Both lncRNA AC105942.1 and hnRNPA2/B1 could be potential therapeutic and diagnostic targets for atherosclerosis-related diseases.

DNA AND CELL BIOLOGY (2021)

Review Cardiac & Cardiovascular Systems

High-density lipoproteins, reverse cholesterol transport and atherogenesis

Henry J. Pownall et al.

Summary: Plasma HDL-cholesterol levels are negatively correlated with the risk of ASCVD, but genetic approaches to increase HDL levels do not reduce this risk. The mechanism of reverse cholesterol transport involving FCh transfer between HDL and macrophages is still under debate in relation to ASCVD.

NATURE REVIEWS CARDIOLOGY (2021)

Review Biotechnology & Applied Microbiology

Targeting inflammation in atherosclerosis - from experimental insights to the clinic

Oliver Soehnlein et al.

Summary: Inflammation plays a substantial role in atherosclerosis and targeting inflammatory pathways could provide a promising new avenue to prevent and treat the disease. Clinical studies have shown that modulation of inflammation can help prevent the clinical complications of atherosclerosis. Refining strategies for combatting inflammation in the disease is crucial for further progress in managing atherosclerotic risk.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Cardiac & Cardiovascular Systems

Protective Functions of Liver X Receptor α in Established Vulnerable Plaques: Involvement of Regulating Endoplasmic Reticulum-Mediated Macrophage Apoptosis and Efferocytosis

Xinyu Che et al.

Summary: This study reveals that LXR activation stabilizes vulnerable plaques and prevents plaque rupture by alleviating macrophage endoplasmic reticulum stress, reducing lesional apoptosis, and improving defective efferocytosis.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

Article Biochemistry & Molecular Biology

Apolipoprotein M promotes cholesterol uptake and efflux from mouse macrophages

Shuang Yao et al.

Summary: This study showed that ApoM is expressed in mouse macrophages and is involved in cholesterol uptake, similar to SR-BI. ApoM-enriched HDL facilitated cholesterol efflux from macrophages, while recombinant human ApoM protein inhibited this ability.

FEBS OPEN BIO (2021)

Article Hematology

A Smooth Muscle Cell-Enriched Long Noncoding RNA Regulates Cell Plasticity and Atherosclerosis by Interacting With Serum Response Factor

Huaner Ni et al.

Summary: The lncRNA CARMN plays a critical role in regulating VSMC plasticity and atherosclerosis by interacting with SRF, which enhances SRF occupancy on VSMC target gene promoters. These findings provide important implications for chronic vascular occlusive diseases.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

Review Biochemistry & Molecular Biology

New insights in statins affecting atheromatous plaque macrophages

Carmen Haerdtner et al.

Summary: Recent research indicates that statins do not directly interact with macrophages in atherosclerotic plaques, but instead control their functions and assembly indirectly through changes in circulating lipid levels and endothelial activation. Statin-mediated lipid lowering induces regression of plaques characterized by a decline in macrophage content, which may inspire new therapeutic approaches in cardiovascular medicine.

CURRENT OPINION IN LIPIDOLOGY (2021)

Review Biochemistry & Molecular Biology

The Effect of Resveratrol on the Cardiovascular System from Molecular Mechanisms to Clinical Results

Roland Gal et al.

Summary: Resveratrol, a natural polyphenol, has been extensively studied for its beneficial effects on the cardiovascular system, including signal transduction pathways, energy metabolism, anti-inflammatory, and antioxidant properties. Research indicates its potential protective role in cardiovascular diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Oncology

SCD1, autophagy and cancer: implications for therapy

Francesca Ascenzi et al.

Summary: Autophagy is an intracellular degradation system that interacts with lipid metabolism, where fatty acids play a crucial role. SCD1 plays a significant role in promoting cell proliferation and metastasis in cancer, but its role in autophagy remains controversial, potentially resulting in either cancer promotion or inhibition depending on cancer heterogeneity and plasticity.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Article Materials Science, Biomaterials

Surface modification of polytetrafluoroethylene (PTFE) with a heparin-immobilized extracellular matrix (ECM) coating for small-diameter vascular grafts applications

Chenglong Yu et al.

Summary: In this study, heparin was immobilized on the ECM coating at different densities to create a bio-favorable environment that selectively inhibited SMC growth while promoting endothelialization. The optimal heparin density was found to be 7.24 +/- 1.56 μg/cm2, striking a balance between antithrombogenicity, endothelialization, and SMC inhibition. Overall, this study proposed a heparin-immobilized ECM coating as a promising strategy to modify PTFE for small-diameter vascular graft development.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Article Pharmacology & Pharmacy

Dead cell and debris clearance in the atherosclerotic plaque: Mechanisms and therapeutic opportunities to promote inflammation resolution

Umesh Kumar Dhawan et al.

Summary: Deficient clearance of dead cells and debris in atherosclerosis is linked to inflammation and thrombotic cardiovascular events. Novel therapeutic strategies to enhance dead cell and debris clearance are crucial for promoting inflammation resolution and plaque stabilization.

PHARMACOLOGICAL RESEARCH (2021)

Article Materials Science, Biomaterials

High-throughput hyaluronic acid hydrogel arrays for cell selective adhesion screening

Cong Wang et al.

Summary: Hyaluronic acid is widely used in the biomedical field, but requires additional functional molecules due to its non-adhesive nature. Cell adhesion peptides such as YIGSR and RGD play important roles in enhancing cell adhesion.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Article Engineering, Biomedical

A biomimetic basement membrane consisted of hybrid aligned nanofibers and microfibers with immobilized collagen IV and laminin for rapid endothelialization

Chenglong Yu et al.

Summary: The study successfully developed a highly biocompatible and biomimetic BBM, which positively influenced the adhesion, proliferation, and survival of endothelial cells, as well as demonstrated good antithrombotic capability and enhanced endothelial cell permeability.

BIO-DESIGN AND MANUFACTURING (2021)

Article Biochemistry & Molecular Biology

Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation

Ryan G. Snodgrass et al.

Summary: The study identified a mechanism whereby macrophages selectively upregulate anti-inflammatory and proresolving genes when exposed to apoptotic cells or LXR agonists and Th2 cytokines, enhancing inflammation resolution and tissue repair.

CELL DEATH AND DIFFERENTIATION (2021)

Article Biochemistry & Molecular Biology

Foam cells promote atherosclerosis progression by releasing CXCL12

Lingxing Li et al.

BIOSCIENCE REPORTS (2020)

Review Cardiac & Cardiovascular Systems

Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis

Stevan D. Stojanovic et al.

EUROPEAN HEART JOURNAL (2020)

Review Nutrition & Dietetics

The Inhibitory Roles of Vitamin K in Progression of Vascular Calcification

Atsushi Shioi et al.

NUTRIENTS (2020)

Article Cardiac & Cardiovascular Systems

CD31 as a Therapeutic Target in Atherosclerosis

Giuseppina Caligiuri

CIRCULATION RESEARCH (2020)

Review Biochemistry & Molecular Biology

Endothelial-to-mesenchymal transition in anticancer therapy and normal tissue damage

Kyu Jin Choi et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Meeting Abstract Biochemistry & Molecular Biology

Regulation of the Phenotypic Switch of Vascular Smooth Muscle Cells by Adiponectin

Abigail Cullen et al.

FASEB JOURNAL (2020)

Review Biochemistry & Molecular Biology

Nutraceuticals for prevention of atherosclerosis: Targeting monocyte infiltration to the vascular endothelium

Min Jeong Kim et al.

JOURNAL OF FOOD BIOCHEMISTRY (2020)

Review Pharmacology & Pharmacy

Medicinal Plants as a Potential and Successful Treatment Option in the Context of Atherosclerosis

Tatiana Kirichenko et al.

FRONTIERS IN PHARMACOLOGY (2020)

Review Pharmacology & Pharmacy

Role of Macrophages in the Progression and Regression of Vascular Calcification

Yalan Li et al.

FRONTIERS IN PHARMACOLOGY (2020)

Review Medical Laboratory Technology

Endogenous ApoA-I expression in macrophages: A potential target for protection against atherosclerosis

Wujun Chen et al.

CLINICA CHIMICA ACTA (2020)

Review Biochemistry & Molecular Biology

Lipid Metabolism in Macrophages: Focus on Atherosclerosis

Vasily N. Sukhorukov et al.

BIOMEDICINES (2020)

Article Pharmacology & Pharmacy

Glucocorticoid-induced leucine zipper modulates macrophage polarization and apoptotic cell clearance

Juliana P. Vago et al.

PHARMACOLOGICAL RESEARCH (2020)

Review Cell & Tissue Engineering

The involving progress of MSCs based therapy in atherosclerosis

Ying Lin et al.

STEM CELL RESEARCH & THERAPY (2020)

Review Engineering, Biomedical

Surface Engineering of Cardiovascular Devices for Improved Hemocompatibility and Rapid Endothelialization

Jing Zhao et al.

ADVANCED HEALTHCARE MATERIALS (2020)

Article Cardiac & Cardiovascular Systems

Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering

Carmen Haerdtner et al.

BASIC RESEARCH IN CARDIOLOGY (2020)

Article Medicine, Research & Experimental

Endothelial to mesenchymal transition contributes to nicotine-induced atherosclerosis

Wei Qin et al.

THERANOSTICS (2020)

Review Cardiac & Cardiovascular Systems

Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis

Stevan D. Stojanovic et al.

EUROPEAN HEART JOURNAL (2020)

Review Cardiac & Cardiovascular Systems

Percutaneous coronary intervention for stable coronary artery disease

Rasha K. Al-Lamee et al.

Review Cardiac & Cardiovascular Systems

Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

Magnus Back et al.

NATURE REVIEWS CARDIOLOGY (2019)

Review Biochemistry & Molecular Biology

An update on lipid oxidation and inflammation in cardiovascular diseases

Shanshan Zhong et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Review Cell Biology

IGF-1 and cardiovascular disease

Yusuke Higashi et al.

GROWTH HORMONE & IGF RESEARCH (2019)

Article Biochemistry & Molecular Biology

Peptide Amphiphile Supramolecular Nanostructures as a Targeted Therapy for Atherosclerosis

Neel A. Mansukhani et al.

MACROMOLECULAR BIOSCIENCE (2019)

Review Pharmacology & Pharmacy

Foam cell formation: A new target for fighting atherosclerosis and cardiovascular disease

Eithne M. Maguire et al.

VASCULAR PHARMACOLOGY (2019)

Review Pharmacology & Pharmacy

The role of smooth muscle cells in plaque stability: Therapeutic targeting potential

Jennifer L. Harman et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Review Cardiac & Cardiovascular Systems

Vascular smooth muscle cells in atherosclerosis

Gemma L. Basatemur et al.

NATURE REVIEWS CARDIOLOGY (2019)

Editorial Material Cardiac & Cardiovascular Systems

The Elusive Late Benefit of Biodegradable Polymer Drug-Eluting Stents

Sripal Bangalore

CIRCULATION (2019)

Article Cardiac & Cardiovascular Systems

Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation

Megan L. Brophy et al.

CIRCULATION RESEARCH (2019)

Article Immunology

Soluble CD93 is an apoptotic cell opsonin recognized by αxβ2

Jack W. D. Blackburn et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Biofunctionalized Electrospun PCL-PIBMD/SF Vascular Grafts with PEG and Cell-Adhesive Peptides for Endothelialization

Lingchuang Bai et al.

MACROMOLECULAR BIOSCIENCE (2019)

Review Endocrinology & Metabolism

ABCA1 and metabolic syndrome; a review of the ABCA1 role in HDL-VLDL production, insulin-glucose homeostasis, inflammation and obesity

Mohammad Mahdi Babashamsi et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2019)

Article Engineering, Biomedical

Direct surface modification of metallic biomaterials via tyrosine oxidation aiming to accelerate the re-endothelialization of vascular stents

Sachiro Kakinoki et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2018)

Review Engineering, Biomedical

Zinc-based alloys for degradable vascular scent applications

Ehsan Mostaed et al.

ACTA BIOMATERIALIA (2018)

Review Cardiac & Cardiovascular Systems

Understanding the role of non-coding RNA (ncRNA) in stent restenosis

Shaoyan Liu et al.

ATHEROSCLEROSIS (2018)

Editorial Material Cardiac & Cardiovascular Systems

The multifaceted role of macrophages in cardiovascular calcification

Marcello Rattazzi et al.

ATHEROSCLEROSIS (2018)

Article Medicine, Research & Experimental

CML/CD36 accelerates atherosclerotic progression via inhibiting foam cell migration

Suining Xu et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Review Cardiac & Cardiovascular Systems

Biodegradable coronary scaffolds: their future and clinical and technological challenges

Jarkko P. Hytonen et al.

CARDIOVASCULAR RESEARCH (2018)

Review Cardiac & Cardiovascular Systems

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness

Andrew L. Durham et al.

CARDIOVASCULAR RESEARCH (2018)

Review Cardiac & Cardiovascular Systems

Endothelial-mesenchymal transition in atherosclerosis

Celine Souilhol et al.

CARDIOVASCULAR RESEARCH (2018)

Review Medicine, Research & Experimental

Atherosclerosis and inflammation: overview and updates

Glaucylara Reis Geovanini et al.

CLINICAL SCIENCE (2018)

Review Pharmacology & Pharmacy

Efferocytosis in atherosclerotic lesions: Malfunctioning regulatory pathways and control mechanisms

Amir Tajbakhsh et al.

PHARMACOLOGY & THERAPEUTICS (2018)

Editorial Material Multidisciplinary Sciences

A unifying concept in vascular health and disease

Martin A. Schwartz et al.

SCIENCE (2018)

Review Cardiac & Cardiovascular Systems

Role of inflammation in the pathogenesis of atherosclerosis and therapeutic interventions

Paolo Raggi et al.

ATHEROSCLEROSIS (2018)

Review Cell Biology

EndMT: A promising and controversial field

Lei Hong et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2018)

Review Cardiac & Cardiovascular Systems

Hyperuricemia and endothelial function: From molecular background to clinical perspectives

Tatsuya Maruhashi et al.

ATHEROSCLEROSIS (2018)

Article Multidisciplinary Sciences

IL-34 promotes foam cell formation by enhancing CD36 expression through p38 MAPK pathway

Qingyan Liu et al.

SCIENTIFIC REPORTS (2018)

Review Cardiac & Cardiovascular Systems

Insights From Pre-Clinical and Clinical Studies on the Role of Innate Inflammation in Atherosclerosis Regression

Karishma Rahman et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2018)

Review Cardiac & Cardiovascular Systems

Mechanisms and Consequences of Defective efferocytosis in Atherosclerosis

Arif Yurdagul et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2018)

Article Hematology

Endothelial Cell-Specific Deletion of P2Y2 Receptor Promotes Plaque Stability in Atherosclerosis-Susceptible ApoE-Null Mice

Xingjuan Chen et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2017)

Article Hematology

Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β Production

Nicolle Ceneri et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2017)

Review Medical Laboratory Technology

Use of Pharmacogenetic Information in the Treatment of Cardiovascular Disease

Kevin Friede et al.

CLINICAL CHEMISTRY (2017)

Review Cardiac & Cardiovascular Systems

Melatonin and Human Cardiovascular Disease

Seithikurippu R. Pandi-Perumal et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS (2017)

Review Pathology

The phenomenon of atherosclerosis reversal and regression: Lessons from animal models

Dimitry A. Chistiakov et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2017)

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Surface modification of endovascular stents with rosuvastatin and heparin-loaded biodegradable nanofibers by electrospinning

Milka Janjic et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Mechanisms of foam cell formation in atherosclerosis

Dimitry A. Chistiakov et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2017)

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Surface biomimetic modification with laminin-loaded heparin/poly-L-lysine nanoparticles for improving the biocompatibility

Tao Liu et al.

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Article Cell Biology

Roles of Cells from the Arterial Vessel Wall in Atherosclerosis

Di Wang et al.

MEDIATORS OF INFLAMMATION (2017)

Article Medicine, Research & Experimental

Interleukin-32 promotes lipid accumulation through inhibition of cholesterol efflux

Zonglei Xu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2017)

Review Multidisciplinary Sciences

The molecular basis of endothelial cell plasticity

Elisabetta Dejana et al.

NATURE COMMUNICATIONS (2017)

Review Biotechnology & Applied Microbiology

Calcifying Matrix Vesicles and Atherosclerosis

Dimitry A. Chistiakov et al.

BIOMED RESEARCH INTERNATIONAL (2017)

Article Multidisciplinary Sciences

A promising biodegradable magnesium alloy suitable for clinical vascular stent application

Lin Mao et al.

SCIENTIFIC REPORTS (2017)

Article Hematology

Endothelial Functions

Shigeo Godo et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2017)

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microRNA-33 Regulates Macrophage Autophagy in Atherosclerosis

Mireille Ouimet et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2017)

Review Cardiac & Cardiovascular Systems

Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis

Ulrich Foerstermann et al.

CIRCULATION RESEARCH (2017)

Review Cell Biology

Macrophage-mediated cholesterol handling in atherosclerosis

Dimitry A. Chistiakov et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2016)

Article Cell Biology

Alternatively activated macrophages exhibit an anticalcifying activity dependent on extracellular ATP/pyrophosphate metabolism

Ricardo Villa-Bellosta et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2016)

Article Hematology

Bone Morphogenic Protein 4-Smad-Induced Upregulation of Platelet-Derived Growth Factor AA Impairs Endothelial Function

Weining Hu et al.

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