4.6 Review

Putative Therapeutic Impact of Inflammasome Inhibitors against COVID-19-Induced ARDS

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Pharmacology & Pharmacy

Conventional and novel therapeutic options in children with familial Mediterranean fever: A rare autoinflammatory disease

Dimitri Poddighe et al.

Summary: Familial Mediterranean fever (FMF) is commonly diagnosed in childhood and is treated predominantly with colchicine, but in cases of intolerance or resistance, the use of biologics, especially interleukin-1 antagonists, should be considered.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2022)

Article Chemistry, Medicinal

Efficacy and safety of colchicine treatment in patients with COVID-19: A prospective, multicenter, randomized clinical trial

Guitti Pourdowlat et al.

Summary: Colchicine has shown clinical benefits in the management of COVID-19 through its anti-inflammatory effect. It can improve clinical outcomes and reduce pulmonary infiltration in COVID-19 patients.

PHYTOTHERAPY RESEARCH (2022)

Review Biochemistry & Molecular Biology

Application of exosomes for the alleviation of COVID-19-related pathologies

Aysa Rezabakhsh et al.

Summary: The COVID-19 pandemic has caused global concern and the lack of effective medications and vaccines, as well as the emergence of resistant strains, have led to worsening public health. Exosomes, nanosized vesicles, have therapeutic properties and can transfer biomolecules and anti-inflammatory cytokines, potentially playing a role in alleviating COVID-19 pathologies.

CELL BIOCHEMISTRY AND FUNCTION (2022)

Review Cell & Tissue Engineering

Emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties

Hadi Rajabi et al.

Summary: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally, mainly due to chronic inflammation and pathological remodeling leading to decreased life span. Recent studies have found that immune cell-derived exosomes play a negative role in the pathogenesis of COPD.

STEM CELL RESEARCH & THERAPY (2022)

Review Pharmacology & Pharmacy

Kinase Inhibitors as Potential Therapeutic Agents in the Treatment of COVID-19

Rajashri R. Naik et al.

Summary: The coronavirus is rapidly spreading worldwide, and viral management aims to disrupt the virus's life cycle, minimize lung damage, and alleviate severe symptoms. Various strategies have been implemented, including repurposing FDA-approved kinase inhibitors that have shown antiviral activity against multiple viruses, including those associated with COVID-19.

FRONTIERS IN PHARMACOLOGY (2022)

Article Cell Biology

Inflammasome formation in the lungs of patients with fatal COVID-19

Stefano Toldo et al.

Summary: The study revealed intense expression of the inflammasome, particularly in leukocytes, within the lungs of all fatal COVID-19 patients. The number of ASC inflammasome specks per high power fields was significantly higher in the lungs of COVID-19 patients compared to controls. This suggests a potential molecular link between viral infection and cytokine release syndrome in fatal COVID-19 pneumonia.

INFLAMMATION RESEARCH (2021)

Article Immunology

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

Tamara S. Rodrigues et al.

Summary: The active NLRP3 inflammasome in response to SARS-CoV-2 infection is associated with disease severity in COVID-19 patients, with higher levels of IL-18 and Casp1p20 correlating with poor clinical outcomes. These findings suggest that inflammasomes may serve as markers of disease severity and potential therapeutic targets for COVID-19.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Review Immunology

Role of melatonin in the angiogenesis potential; highlights on the cardiovascular disease

Afshin Rahbarghazi et al.

Summary: Melatonin has multi-organ and pleiotropic effects in controlling angiogenesis at the molecular and cellular levels. Angiogenesis, the development of new blood vessels from pre-existing ones, is dependent on the balance of pro- and anti-angiogenic factors. Accelerating angiogenesis is seen as an effective strategy in healing ischemic changes like infarcted myocardium.

JOURNAL OF INFLAMMATION-LONDON (2021)

Review Multidisciplinary Sciences

Colchicine use in patients with COVID-19: A systematic review and meta-analysis

Leonard Chiu et al.

Summary: This study reviewed the use of colchicine in COVID-19 patients and found that it may reduce the risk of mortality. However, there was no significant difference in the risk of ICU admissions between patients who received colchicine and those who did not. Further research is needed to determine the efficacy of colchicine in various care settings for COVID-19 patients.

PLOS ONE (2021)

Article Cell & Tissue Engineering

Does the Global Outbreak of COVID-19 or Other Viral Diseases Threaten the Stem Cell Reservoir Inside the Body?

Hesam Saghaei Bagheri et al.

Summary: The COVID-19 pandemic has had a profound impact on global public health and economies, with long-lasting consequences expected due to high prevalence and mortality rates. The rapid spread of the virus and lack of pathogenicity data has forced governments to quickly respond to the complexity of the situation.

STEM CELL REVIEWS AND REPORTS (2021)

Article Rheumatology

Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial

Maria Isabel Lopes et al.

Summary: Colchicine showed benefits in the treatment of COVID-19 patients by reducing the need for supplemental oxygen and length of hospitalisation. It did not necessarily reduce mortality, but was safe and well tolerated with the potential side effect of diarrhea.

RMD OPEN (2021)

Article Cardiac & Cardiovascular Systems

Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease

Antonio Abbate et al.

CIRCULATION RESEARCH (2020)

Editorial Material Critical Care Medicine

Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation

Daniel E. Leisman et al.

INTENSIVE CARE MEDICINE (2020)

Article Infectious Diseases

Aminoquinolines against coronavirus disease 2019 (COVID-19): chloroquine or hydroxychloroquine

Zahra Sahraei et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

Letter Virology

Metformin and COVID-19: A novel deal of an old drug

Amr Ahmed EL-Arabey et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

Letter Medicine, General & Internal

COVID-19: consider cytokine storm syndromes and immunosuppression

Puja Mehta et al.

LANCET (2020)

Letter Critical Care Medicine

COVID-19 cytokine storm: the interplay between inflammation and coagulation

Ricardo J. Jose et al.

LANCET RESPIRATORY MEDICINE (2020)

Article Medicine, General & Internal

Hydroxychloroquine in Nonhospitalized Adults With Early COVID-19 A Randomized Trial

Caleb P. Skipper et al.

ANNALS OF INTERNAL MEDICINE (2020)

Review Pharmacology & Pharmacy

Statins: Could an old friend help in the fight against COVID-19?

Raul R. Rodrigues-Diez et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Article Pharmacology & Pharmacy

Inhibition of Bruton's TK regulates macrophage NF-κB and NLRP3 inflammasome activation in metabolic inflammation

Gareth S. D. Purvis et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Review Immunology

Severe COVID-19: NLRP3 Inflammasome Dysregulated

Daan F. van den Berg et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Immunology

Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies

Yujun Tang et al.

FRONTIERS IN IMMUNOLOGY (2020)

Editorial Material Medicine, General & Internal

Monoclonal Antibodies for Prevention and Treatment of COVID-19

Mary Marovich et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Cell Biology

Tranilast Directly Targets NLRP3 to Protect Melanocytes From Keratinocyte-Derived IL-1β Under Oxidative Stress

Tongtian Zhuang et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Critical Care Medicine

A systematic review on the ef ficacy and safety of chloroquine for the treatment of COVID-19

Andrea Cortegiani et al.

JOURNAL OF CRITICAL CARE (2020)

Review Respiratory System

The Outcome of Hydroxychloroquine in Patients Treated for COVID-19: Systematic Review and Meta-Analysis

Teshale Ayele Mega et al.

CANADIAN RESPIRATORY JOURNAL (2020)

Editorial Material Medicine, General & Internal

Hydroxychloroquine for the Prevention of Covid-19-Searching for Evidence

Myron S. Cohen

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19

David R. Boulware et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Biochemistry & Molecular Biology

SARS-CoV-2 and the possible connection to ERs, ACE2, and RAGE: Focus on susceptibility factors

Roberta Sessa Stilhano et al.

FASEB JOURNAL (2020)

Article Medicine, General & Internal

Colchicine in Patients with Chronic Coronary Disease

Stefan M. Nidorf et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Pharmacology & Pharmacy

Pharmacological treatments of COVID-19

Adeleh Sahebnasagh et al.

PHARMACOLOGICAL REPORTS (2020)

Article Pharmacology & Pharmacy

The prophylaxis and treatment potential of supplements for COVID-19

Adeleh Sahebnasagh et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Review Medicine, General & Internal

The Possible Immunological Pathways for the Variable Immunopathogenesis of COVID-19 Infections among Healthy Adults, Elderly and Children

Ahmed S. Abdulamir et al.

ELECTRONIC JOURNAL OF GENERAL MEDICINE (2020)

Review Biochemistry & Molecular Biology

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

Nathan Kelley et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Oncology

Inflammasome inhibitors: promising therapeutic approaches against cancer

Shengchao Xu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Article Multidisciplinary Sciences

Caspase-1 initiates apoptosis in the absence of gasdermin D

Kohsuke Tsuchiya et al.

NATURE COMMUNICATIONS (2019)

Review Immunology

Gasdermin D activity in inflammation and host defense

Judy Lieberman et al.

SCIENCE IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy

Fan Yang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

Review Cardiac & Cardiovascular Systems

The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation

Gonzalo J. Martinez et al.

ATHEROSCLEROSIS (2018)

Review Endocrinology & Metabolism

Is metformin poised for a second career as an antimicrobial?

Faiza Malik et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2018)

Article Medicine, Research & Experimental

Tranilast directly targets NLRP3 to treat inflammasome-driven diseases

Yi Huang et al.

EMBO MOLECULAR MEDICINE (2018)

Article Immunology

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

Dave Boucher et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

Article Medicine, Research & Experimental

RIP3 dependent NLRP3 inflammasome activation is implicated in acute lung injury in mice

Jingxian Chen et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2018)

Article Pathology

Protective effects of melatonin on long-term administration of fluoxetine in rats

Majid Khaksar et al.

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY (2017)

Article Endocrinology & Metabolism

Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue

Zhenjiang Liu et al.

JOURNAL OF PINEAL RESEARCH (2017)

Article Rheumatology

Update on colchicine, 2017

Anastasia Slobodnick et al.

RHEUMATOLOGY (2017)

Review Endocrinology & Metabolism

Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation

Gaia Favero et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2017)

Review Immunology

The Role of Interferons in Inflammation and Inflammasome Activation

Natasa Kopitar-Jerala

FRONTIERS IN IMMUNOLOGY (2017)

Article Multidisciplinary Sciences

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

Michiru Nishita et al.

SCIENTIFIC REPORTS (2017)

Article Pharmacology & Pharmacy

Uricosuric targets of tranilast

Asim K. Mandal et al.

PHARMACOLOGY RESEARCH & PERSPECTIVES (2017)

Review Pharmacology & Pharmacy

The Safety of Melatonin in Humans

Lars Peter Holst Andersen et al.

CLINICAL DRUG INVESTIGATION (2016)

Review Endocrinology & Metabolism

Melatonin as an antioxidant: under promises but over delivers

Russel J. Reiter et al.

JOURNAL OF PINEAL RESEARCH (2016)

Article Endocrinology & Metabolism

Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome

Yong Zhang et al.

JOURNAL OF PINEAL RESEARCH (2016)

Article Cardiac & Cardiovascular Systems

NLRP3 inflammasome in peripheral blood monocytes of acute coronary syndrome patients and its relationship with statins

Afrasyab Altaf et al.

CORONARY ARTERY DISEASE (2015)

Review Pharmacology & Pharmacy

Tranilast: A review of its therapeutic applications

Sara Darakhshan et al.

PHARMACOLOGICAL RESEARCH (2015)

Review Cardiac & Cardiovascular Systems

Targeting Cholesterol Crystal-Induced Inflammation for the Secondary Prevention of Cardiovascular Disease

Stefan M. Nidorf et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS (2014)

Review Immunology

Targeting the Cytokine Storm for Therapeutic Benefit

Riccardo V. D'Elia et al.

CLINICAL AND VACCINE IMMUNOLOGY (2013)

Article Multidisciplinary Sciences

High-level semi-synthetic production of the potent antimalarial artemisinin

C. J. Paddon et al.

NATURE (2013)

Article Endocrinology & Metabolism

Melatonin reduces lung oxidative stress in patients with chronic obstructive pulmonary disease: a randomized, double-blind, placebo-controlled study

Antonio George de Matos Cavalcante et al.

JOURNAL OF PINEAL RESEARCH (2012)

Review Microbiology

Viroporins: structure and biological functions

Jose Luis Nieva et al.

NATURE REVIEWS MICROBIOLOGY (2012)

Review Immunology

Caspase-1-induced pyroptotic cell death

Edward A. Miao et al.

IMMUNOLOGICAL REVIEWS (2011)

Article Critical Care Medicine

Melatonin in septic shock: Some recent concepts

Venkataramanujan Srinivasan et al.

JOURNAL OF CRITICAL CARE (2010)

Review Medicine, General & Internal

Statins for the Prevention and Treatment of Infections A Systematic Review and Meta-analysis

Imad M. Tleyjeh et al.

ARCHIVES OF INTERNAL MEDICINE (2009)

Review Chemistry, Medicinal

Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin

Bhabatarak Bhattacharyya et al.

MEDICINAL RESEARCH REVIEWS (2008)

Article Cardiac & Cardiovascular Systems

The inflammation hypothesis and its potential relevance to statin therapy

James S. Forrester et al.

AMERICAN JOURNAL OF CARDIOLOGY (2007)

Article Multidisciplinary Sciences

Gout-associated uric acid crystals activate the NALP3 inflammasome

F Martinon et al.

NATURE (2006)

Review Clinical Neurology

Melatonin as a chronobiotic

J Arendt et al.

SLEEP MEDICINE REVIEWS (2005)

Review Clinical Neurology

The basic physiology and pathophysiology of melatonin

B Claustrat et al.

SLEEP MEDICINE REVIEWS (2005)

Article Multidisciplinary Sciences

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

S Mariathasan et al.

NATURE (2004)

Review Cardiac & Cardiovascular Systems

Effects of statins on vascular wall: vasomotor function, inflammation, and plaque stability

KK Koh

CARDIOVASCULAR RESEARCH (2000)