Putative Therapeutic Impact of Inflammasome Inhibitors against COVID-19-Induced ARDS

Given the importance of COVID-19-induced ARDS, recently, researchers have strived to determine underlying mechanisms involved in the inflammatory responses. In this regard, inflammasomes possess a distinct priority for cytokine storm occurrence and, subsequently, ARDS progression in ill patients with SARS-CoV-2 infection. In this mini-review, the characteristics of known inflammasome inhibitors and designed research in this field were concretely deciphered.

Automated summary

Given the significance of COVID-19-induced ARDS, researchers have recently focused on identifying the underlying mechanisms of inflammatory responses. Inflammasomes play a crucial role in cytokine storm development and subsequent ARDS progression in patients with SARS-CoV-2 infection. This mini-review provides a comprehensive analysis of known inflammasome inhibitors and ongoing research in this field.