A Review of Statin Intolerance: a Focus on Statin-Attributed Muscle Symptoms

Purpose of Review To provide a systematic approach to management of the patient with statin-attributed muscle symptoms. Recent Findings We examined the prevalence of statin intolerance, the role of the nocebo effect, key findings in the patient's history and laboratory studies, the potential value of coronary calcium scoring, and the importance of shared decision-making in considering statin re-initiation. Most patients with statin-attributed muscle symptoms can be successfully treated with statins or a combination of statins and non-statins to achieve successful ASCVD risk reduction.

Automated summary

The purpose of this review is to provide a systematic approach to managing patients with statin-attributed muscle symptoms. Recent findings include the prevalence of statin intolerance, the role of the nocebo effect, key findings in patients' history and laboratory studies, the potential value of coronary calcium scoring, and the importance of shared decision-making in considering statin re-initiation. Most patients with statin-attributed muscle symptoms can achieve successful ASCVD risk reduction through treatment with statins or a combination of statins and non-statins.