4.3 Review

The safety and efficacy of low oral doses of cannabidiol: An evaluation of the evidence

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Neurosciences

Effects of cannabidiol on symptoms induced by the recall of traumatic events in patients with posttraumatic stress disorder

Livia Maria Bolsoni et al.

Summary: Studies suggest that CBD has anxiolytic properties and may attenuate symptoms induced by recall of traumatic events in individuals with PTSD. This double-blind trial found that CBD in a dosage of 300 mg significantly reduced cognitive impairment associated with trauma recall, with this effect lasting for a week after administration. However, CBD did not significantly affect anxiety, alertness, or discomfort induced by recall, and there were no differences in physiological measures between the CBD and placebo groups.

PSYCHOPHARMACOLOGY (2022)

Article Pharmacology & Pharmacy

A placebo-controlled investigation of the analgesic effects, abuse liability, safety and tolerability of a range of oral cannabidiol doses in healthy humans

Caroline A. Arout et al.

Summary: This study found that acute oral CBD did not consistently demonstrate dose-dependent analgesic effects in healthy noncannabis users, and in fact increased pain in some measures. Future studies should consider using more comprehensive pain assessment paradigms and investigate the analgesic effects of CBD in different populations.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2022)

Article Anesthesiology

Cannabidiol treatment in hand osteoarthritis and psoriatic arthritis: a randomized, double-blind, placebo-controlled trial

Jonathan Vela et al.

Summary: This study aimed to investigate the use of CBD as an adjuvant analgesic therapy in patients with hand osteoarthritis or psoriatic arthritis. The results showed no significant effects of CBD on pain intensity, sleep quality, depression, anxiety, or pain catastrophizing scores compared to placebo.
Article Psychiatry

Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters

Jose A. Crippa et al.

Summary: This study compared plasma concentrations of CBD following oral administration of two formulations (powder and oil) and evaluated their effects on responses to emotional stimuli. The results showed that neither formulation altered responses to emotional stimuli in healthy subjects, but the oil-based CBD formulation had a faster onset and higher oral bioavailability.

BRAZILIAN JOURNAL OF PSYCHIATRY (2022)

Article Psychiatry

The anxiolytic effect of cannabidiol depends on the nature of the trauma when patients with post-traumatic stress disorder recall their trigger event

Livia Maria Bolsoni et al.

Summary: Administering CBD before recalling traumatic events may attenuate anxiety in patients with PTSD, but this effect is not significant in cases involving sexual trauma.

BRAZILIAN JOURNAL OF PSYCHIATRY (2022)

Article Nutrition & Dietetics

Cannabidiol and Cannabidiol Metabolites: Pharmacokinetics, Interaction with Food, and Influence on Liver Function

Kieran Shay Struebin Abbotts et al.

Summary: The study found significant pharmacokinetic differences between commercial CBD formulations, CBD is unlikely to affect the caloric cost of eating, but may benefit initial metabolic responses, consuming CBD with food alters the dynamics of CBD metabolism and increases systemic availability, low-dose CBD may not pose a risk to normal liver function.

NUTRIENTS (2022)

Article Pharmacology & Pharmacy

Medicinal Cannabis Prescribing in Australia: An Analysis of Trends Over the First Five Years

Sara L. MacPhail et al.

Summary: This article analyzes the prescribing trends of medicinal cannabis in Australia since 2016. The results show that pain, anxiety, and sleep disorders are the leading indications for approvals, and oil products are the most popular type. In recent years, there has been an increase in approvals for younger patients, male patients, and non-CBD dominant products.

FRONTIERS IN PHARMACOLOGY (2022)

Article Sport Sciences

Effects of Cannabidiol on Exercise Physiology and Bioenergetics: A Randomised Controlled Pilot Trial

Ayshe Sahinovic et al.

Summary: This pilot study investigated the effects of acute, oral CBD treatment on physiological and psychological responses to aerobic exercise. The results suggested that CBD may increase oxygen uptake, pleasure ratings, and lactate concentrations during exercise, while reducing endogenous cannabinoid concentrations. The study suggests that CBD may alter some key physiological and psychological responses to exercise without impairing performance. Larger studies are needed to confirm and further understand these preliminary findings.

SPORTS MEDICINE-OPEN (2022)

Article Pharmacology & Pharmacy

Cannabidiol and Abnormal Liver Chemistries in Healthy Adults: Results of a Phase I Clinical Trial

Paul B. Watkins et al.

Summary: Liver safety concerns have been raised in healthy adults consuming therapeutic daily doses of CBD, with some experiencing drug-induced liver injury characterized by elevated serum ALT values. However, there was no correlation found between transaminase elevations and baseline characteristics, pharmacogenetic, or pharmacokinetic data.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

Article Sport Sciences

The Effects of Cannabidiol Oil on Noninvasive Measures of Muscle Damage in Men

Kristen C. Cochrane-Snyman et al.

Summary: The study found that CBD oil had no effect on noninvasive markers of muscle damage, showing no condition-time interaction or main effect of condition. However, there were main effects for time on perceived soreness and hanging joint angle.

MEDICINE & SCIENCE IN SPORTS & EXERCISE (2021)

Article Chemistry, Medicinal

Comparison of Five Oral Cannabidiol Preparations in Adult Humans: Pharmacokinetics, Body Composition, and Heart Rate Variability

Natasha N. Bondareva Williams et al.

Summary: The study compared the pharmacokinetics of five oral CBD preparations over 4 hours, finding that a preparation with 5% CBD concentration liquid had superior CBD concentration, time, and area under the curve. Fat-free mass was a significant predictor of time to peak concentration for this preparation, and acute CBD ingestion may have a modest influence on autonomic regulation of heart rate.

PHARMACEUTICALS (2021)

Article Clinical Neurology

A single oral dose of cannabidiol did not reduce upper limb tremor in patients with essential tremor

Stela Santos de Alencar et al.

Summary: This study found that a single 300 mg oral dose of CBD did not have a significant effect on the severity of upper limb tremors in patients with essential tremor. The findings did not rule out the possibility that chronic treatment with CBD could have a symptomatic effect.

PARKINSONISM & RELATED DISORDERS (2021)

Article Psychiatry

Cannabidiol for the treatment of crack-cocaine craving: an exploratory double-blind study

Carolina de Meneses-Gaya et al.

Summary: The study showed a significant reduction in craving levels over the 10-day period in both CBD and placebo groups, with no differences between them. CBD did not have an effect on symptoms of anxiety, depression, and sleep alterations. Further studies with larger outpatient samples involving different doses and treatment periods are needed to investigate the potential of CBD in reducing crack-cocaine self-administration.

BRAZILIAN JOURNAL OF PSYCHIATRY (2021)

Letter Pharmacology & Pharmacy

Cannabidiol as a Treatment for Mental Health Outcomes Among Health Care Workers During the Coronavirus Disease Pandemic

Julia Cozar Pacheco et al.

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2021)

Article Medicine, General & Internal

The CANBACK trial: a randomised, controlled clinical trial of oral cannabidiol for people presenting to the emergency department with acute low back pain

Bronwyn Bebee et al.

Summary: In the emergency department, single-dose oral CBD is not superior to placebo in relieving acute non-traumatic low back pain. Pain scores, length of stay, use of rescue analgesia, and reported side effects were similar between the two groups.

MEDICAL JOURNAL OF AUSTRALIA (2021)

Article Chemistry, Medicinal

Improved Bioavailability with Dry Powder Cannabidiol Inhalation: A Phase 1 Clinical Study

Orrin Devinsky et al.

Summary: Oral CBD formulations are limited by hepatic metabolism, while inhaled CBD bypasses this issue, providing higher bioavailability and faster onset. The study demonstrates that the dry-powder inhaler CBD formulation showed better pharmacokinetic performance in healthy participants compared to oral CBD solution.

JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

Article Nutrition & Dietetics

Effects of Cannabidiol Supplementation on Skeletal Muscle Regeneration after Intensive Resistance Training

Eduard Isenmann et al.

Summary: The study found that single CBD supplementation had small but significant effects on muscle damage and recovery of squat performance after 72 hours in athletes. However, more data is needed to make clearer statements about the potential pro-regenerative effects of CBD supplementation after resistance training.

NUTRIENTS (2021)

Article Medicine, General & Internal

A primer on medicinal cannabis safety and potential adverse effects

Jonathon C Arnold

Australian Journal of General Practice (2021)

Article Medicine, General & Internal

Efficacy and Safety of Cannabidiol Plus Standard Care vs Standard Care Alone for the Treatment of Emotional Exhaustion and Burnout Among Frontline Health Care Workers During the COVID-19 Pandemic A Randomized Clinical Trial

Jose Alexandre S. Crippa et al.

Summary: CBD therapy reduced burnout and emotional exhaustion symptoms among frontline health care professionals working with COVID-19 patients. However, potential undesired or adverse effects of CBD therapy need to be carefully balanced. Future double-blind placebo-controlled clinical trials are needed to confirm these findings.

JAMA NETWORK OPEN (2021)

Review Biochemistry & Molecular Biology

Serious adverse effects of cannabidiol (CBD): a review of randomized controlled trials

Rafael G. Dos Santos et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2020)

Article Pharmacology & Pharmacy

Pharmacokinetic investigation of synthetic cannabidiol oral formulations in healthy volunteers

Dvora Izgelov et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)

Article Substance Abuse

Access to cannabidiol without a prescription: A cross-country comparison and analysis

Iain S. McGregor et al.

INTERNATIONAL JOURNAL OF DRUG POLICY (2020)

Article Pharmacology & Pharmacy

Oral Cannabidiol Does Not Convert to Δ8-THC or Δ9-THC in Humans: A Pharmacokinetic Study in Healthy Subjects

Jose Alexandre S. Crippa et al.

CANNABIS AND CANNABINOID RESEARCH (2020)

Article Pharmacology & Pharmacy

Prescribing medicinal cannabis

Jonathon C. Arnold et al.

AUSTRALIAN PRESCRIBER (2020)

Review Pharmacology & Pharmacy

A Review of Human Studies Assessing Cannabidiol's (CBD) Therapeutic Actions and Potential

C. Michael White

JOURNAL OF CLINICAL PHARMACOLOGY (2019)

Review Pharmacology & Pharmacy

A systematic review of cannabidiol dosing in clinical populations

S. A. Millar et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2019)

Review Neurosciences

Cannabidiol (CBD) use in psychiatric disorders: A systematic review

Stefania Bonaccorso et al.

NEUROTOXICOLOGY (2019)

Article Psychiatry

Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test

Ila M. Linares et al.

BRAZILIAN JOURNAL OF PSYCHIATRY (2019)

Review Substance Abuse

Cannabidiol as a Novel Candidate Alcohol Use Disorder Pharmacotherapy: A Systematic Review

Jasmine Turna et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2019)

Review Pharmacology & Pharmacy

The Potential for Pharmacokinetic Interactions Between Cannabis Products and Conventional Medications

Yuli Qian et al.

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2019)

Review Pharmacology & Pharmacy

A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans

Sophie A. Millar et al.

FRONTIERS IN PHARMACOLOGY (2018)

Article Pharmacology & Pharmacy

Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life

Antonio W. Zuardi et al.

Frontiers in Pharmacology (2017)

Article Pharmacology & Pharmacy

Cannabidiol Does Not Dampen Responses to Emotional Stimuli in Healthy Adults

David L. Arndt et al.

CANNABIS AND CANNABINOID RESEARCH (2017)

Article Gastroenterology & Hepatology

Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn's Disease, a Randomized Controlled Trial

Timna Naftali et al.

DIGESTIVE DISEASES AND SCIENCES (2017)

Review Pharmacology & Pharmacy

An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies

Kerstin Iffland et al.

CANNABIS AND CANNABINOID RESEARCH (2017)

Article Biochemistry & Molecular Biology

Fatty Acid-binding Proteins (FABPs) Are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)

Matthew W. Elmes et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Review Clinical Neurology

Molecular Targets of Cannabidiol in Neurological Disorders

Clementino Ibeas Bih et al.

NEUROTHERAPEUTICS (2015)

Article Clinical Neurology

Effects of cannabidiol in the treatment of patients with Parkinson's disease: An exploratory double-blind trial

Marcos Hortes N. Chagas et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2014)

Article Public, Environmental & Occupational Health

The weight of nations: an estimation of adult human biomass

Sarah Catherine Walpole et al.

BMC PUBLIC HEALTH (2012)

Article Clinical Neurology

Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report

Jose Alexandre S. Crippa et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2011)

Article Clinical Neurology

Cannabidiol for the treatment of psychosis in Parkinson's disease

A. W. Zuardi et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2009)

Review Neurosciences

Effects of cannabidiol (CBD) on regional cerebral blood flow

JAD Crippa et al.

NEUROPSYCHOPHARMACOLOGY (2004)